Showing papers by "Joachim Heinrich published in 2018"
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Florence Demenais1, Florence Demenais2, Patricia Margaritte-Jeannin1, Patricia Margaritte-Jeannin2 +213 more•Institutions (79)
TL;DR: A meta-analysis of GWAS studies for asthma from multiancestral cohorts identifies five new loci and finds that the asthma-associated loci are enriched near enhancer marks in immune cells, suggesting a major role of these loci in the regulation of immunologically related mechanisms.
Abstract: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
363 citations
03 Feb 2018
281 citations
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TL;DR: In this article, the authors performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals.
Abstract: C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 10−8). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We identified 66 gene sets that were organized in two substantially correlated clusters, one mainly composed of immune pathways and the other characterized by metabolic pathways in the liver. Mendelian randomization analyses revealed a causal protective effect of CRP on schizophrenia and a risk-increasing effect on bipolar disorder. Our findings provide further insights into the biology of inflammation and could lead to interventions for treating inflammation and its clinical consequences.
244 citations
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TL;DR: The performance of the missing transverse momentum reconstruction with the ATLAS detector is evaluated using data collected in proton–proton collisions at the LHC at a centre-of-mass energy of 13 TeV in 2015.
Abstract: The performance of the missing transverse momentum ( ETmiss ) reconstruction with the ATLAS detector is evaluated using data collected in proton-proton collisions at the LHC at a centre-of-mass energy of 13 TeV in 2015. To reconstruct ETmiss , fully calibrated electrons, muons, photons, hadronically decaying τ-leptons , and jets reconstructed from calorimeter energy deposits and charged-particle tracks are used. These are combined with the soft hadronic activity measured by reconstructed charged-particle tracks not associated with the hard objects. Possible double counting of contributions from reconstructed charged-particle tracks from the inner detector, energy deposits in the calorimeter, and reconstructed muons from the muon spectrometer is avoided by applying a signal ambiguity resolution procedure which rejects already used signals when combining the various ETmiss contributions. The individual terms as well as the overall reconstructed ETmiss are evaluated with various performance metrics for scale (linearity), resolution, and sensitivity to the data-taking conditions. The method developed to determine the systematic uncertainties of the ETmiss scale and resolution is discussed. Results are shown based on the full 2015 data sample corresponding to an integrated luminosity of 3.2fb-1 .
208 citations
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TL;DR: In this article, a search was performed for resonant and non-resonant Higgs boson pair production in the $ \upgamma \ upgamma b\overline{b} $ final state.
Abstract: A search is performed for resonant and non-resonant Higgs boson pair production in the $ \upgamma \upgamma b\overline{b} $ final state. The data set used corresponds to an integrated luminosity of 36.1 fb$^{−1}$ of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. No significant excess relative to the Standard Model expectation is observed. The observed limit on the non-resonant Higgs boson pair cross-section is 0.73 pb at 95% confidence level. This observed limit is equivalent to 22 times the predicted Standard Model cross-section. The Higgs boson self-coupling (κ$_{λ}$ = λ$_{HHH}$/λ$_{HHH}^{SM}$ ) is constrained at 95% confidence level to −8.2 < κ$_{λ}$ < 13.2. For resonant Higgs boson pair production through $ X\to HH\to \upgamma \upgamma b\overline{b} $ , the limit is presented, using the narrow-width approximation, as a function of m$_{X}$ in the range 260 GeV < m$_{X}$ < 1000 GeV. The observed limits range from 1.1 pb to 0.12 pb over this mass range.
202 citations
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TL;DR: In this paper, the mass of the $W$ boson was measured based on proton-proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC.
Abstract: A measurement of the mass of the $W$ boson is presented based on proton-proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to 4.6 fb$^{-1}$ of integrated luminosity. The selected data sample consists of $7.8 \times 10^6$ candidates in the $W\rightarrow \mu
u$ channel and $5.9 \times 10^6$ candidates in the $W\rightarrow e
u$ channel. The $W$-boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the $W$ boson transverse mass in the electron and muon decay channels, yielding \begin{eqnarray} m_W &=& 80370 \pm 7 \, (\textrm{stat.}) \pm 11 \, (\textrm{exp. syst.}) \pm 14 \, (\textrm{mod. syst.}) \, \textrm{MeV} &=& 80370 \pm 19 \, \textrm{MeV}, \end{eqnarray} where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty. A measurement of the mass difference between the $W^+$ and $W^-$ bosons yields $m_{W^+}-m_{W^-} = -29 \pm 28$ MeV.
195 citations
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TL;DR: Combined 95% confidence-level upper limits are set on the production cross section for a range of vectorlike quark scenarios, significantly improving upon the reach of the individual searches.
Abstract: A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T -> Zt/Wb/Ht, B -> Zb/Wt/Hb) is performed using 36.1 fb(-1) of pp ...
174 citations
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TL;DR: In this paper, an upper bound of 0.0025% and 0.031% for the cross-section of the charged Higgs boson times the branching fraction in the range 4.2-4.5 pb was established for the mass range 90-160 GeV.
Abstract: Charged Higgs bosons produced either in top-quark decays or in association with a top-quark, subsequently decaying via H$^{±}$ → τ$^{±}$ν$_{τ}$, are searched for in 36.1 fb$^{−1}$ of proton-proton collision data at $ \sqrt{s}=13 $ TeV recorded with the ATLAS detector. Depending on whether the top-quark produced together with H$^{±}$ decays hadronically or leptonically, the search targets τ+jets and τ+lepton final states, in both cases with a hadronically decaying τ-lepton. No evidence of a charged Higgs boson is found. For the mass range of $ {m}_{H^{\pm }} $ = 90–2000 GeV, upper limits at the 95% confidence level are set on the production cross-section of the charged Higgs boson times the branching fraction $ \mathrm{\mathcal{B}}\left({H}^{\pm}\to {\tau}^{\pm }{
u}_{\tau}\right) $ in the range 4.2–0.0025 pb. In the mass range 90–160 GeV, assuming the Standard Model cross-section for $ t\overline{t} $ production, this corresponds to upper limits between 0.25% and 0.031% for the branching fraction $ \mathrm{\mathcal{B}}\left(t\to b{H}^{\pm}\right)\times \mathrm{\mathcal{B}}\left({H}^{\pm}\to {\tau}^{\pm }{
u}_{\tau}\right) $ .
154 citations
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TL;DR: Long-term exposure to air pollution was associated with increased risk of diabetes in the Chinese population, particularly in individuals who were younger or overweight or obese.
151 citations
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TL;DR: A search for supersymmetric partners of quarks and gluons in final states containing hadronic jets and missing transverse momentum, but no electrons or muons, is presented in this article.
Abstract: A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states containing hadronic jets and missing transverse momentum, but no electrons or muons, is presented ...
149 citations
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TL;DR: Allergy immunotherapy (AIT) is the only treatment for allergic rhinitis (AR) and/or allergic asthma (AA) with long‐term efficacy with long-term efficacy, however, there are few real‐life data on the progression of AR and/ or AA in patients receiving AIT.
Abstract: Background
Allergy immunotherapy (AIT) is the only treatment for allergic rhinitis (AR) and/or allergic asthma (AA) with long-term efficacy. However, there are few real-life data on the progression of AR and/or AA in patients receiving AIT.
Objectives
To assess the real-world, long-term efficacy of grass pollen sublingual immunotherapy (SLIT) tablets in AR and their impact on asthma onset and progression.
Methods
In a retrospective analysis of a German longitudinal prescription database, AR patients treated with grass pollen SLIT tablets were compared with a control group not having received AIT. Multiple regression analysis was used to compare changes over time in rescue symptomatic AR medication use after treatment cessation, asthma medication use, and the time to asthma onset in the two groups.
Results
After applying all selection criteria, 2851 SLIT and 71 275 control patients were selected for the study. After treatment cessation, AR medication use was 18.8 percentage points lower (after adjustment for covariates, and relative to the pretreatment period) in SLIT tablet group than in the non-AIT group (P<.001). Asthma onset was less frequent in SLIT tablet group than in non-AIT group (odds ratio: 0.696, P=.002), and time to asthma was significantly longer (hazard ratio: 0.523; P=.003). After SLIT cessation, asthma medication use fell by an additional 16.7 percentage points (relative to the pretreatment period) in the SLIT tablet group vs the non-AIT group (P=.004).
Conclusions
Real-world treatment of AR patients with grass pollen SLIT tablets was associated with slower AR progression, less frequent asthma onset, and slower asthma progression.
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Sun Yat-sen University1, Ludwig Maximilian University of Munich2, Saint Louis University3, Washington University in St. Louis4, Monash University5, Institute of Fundamental Studies6, University of Melbourne7, The Chinese University of Hong Kong8, State University of New York System9, Li Ka Shing Faculty of Medicine, University of Hong Kong10
TL;DR: Long-term ambient air pollution was associated with both altered lipid profiles and dyslipidemias, especially among overweight or obese participants; sex and age modified the associations, but the pattern of effects was mixed.
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TL;DR: In this paper, a search for heavy resonances decaying into a pair of bosons leading to the final states, where $$\ell $$¯¯ stands for either an electron or a muon, is presented.
Abstract: A search for heavy resonances decaying into a pair of $$Z$$
bosons leading to $$\ell ^+\ell ^-\ell ^+\ell ^-$$
and $$\ell ^+\ell ^-
u \bar{
u }$$
final states, where $$\ell $$
stands for either an electron or a muon, is presented. The search uses proton–proton collision data at a centre-of-mass energy of 13
$$\text {TeV}$$
corresponding to an integrated luminosity of 36.1
$$\hbox {fb}^{-1}$$
collected with the ATLAS detector during 2015 and 2016 at the Large Hadron Collider. Different mass ranges for the hypothetical resonances are considered, depending on the final state and model. The different ranges span between 200 and 2000
$$\text {GeV}$$
. The results are interpreted as upper limits on the production cross section of a spin-0 or spin-2 resonance. The upper limits for the spin-0 resonance are translated to exclusion contours in the context of Type-I and Type-II two-Higgs-doublet models, while those for the spin-2 resonance are used to constrain the Randall–Sundrum model with an extra dimension giving rise to spin-2 graviton excitations.
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TL;DR: In this article, a search for neutral heavy resonances was performed in the WW -> e nu mu nu decay channel using collision data corresponding to an integrated luminosity of 36.1 fb(-1).
Abstract: A search for neutral heavy resonances is performed in the WW -> e nu mu nu decay channel using pp collision data corresponding to an integrated luminosity of 36.1 fb(-1), collected at a centre-o ...
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TL;DR: Searches for new heavy resonances decaying into different pairings of W, Z, or Higgs bosons, as well as dirffiffiffiffiectly into leptons, are presented using a data sample corresponding to 36.1 fb(-1...
Abstract: Searches for new heavy resonances decaying into different pairings of W, Z, or Higgs bosons, as well as dirffiffiffiectly into leptons, are presented using a data sample corresponding to 36.1 fb(-1 ...
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TL;DR: In this paper, the authors search for heavy resonances decaying into ZZ or ZW using data from proton-proton collisions at a center-of-mass energy of root s - 13 TeV.
Abstract: This paper reports searches for heavy resonances decaying into ZZ or ZW using data from proton-proton collisions at a centre-of-mass energy of root s - 13 TeV. The data, corresponding to an integra ...
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University of Verona1, University of Bergen2, University of Iceland3, Haukeland University Hospital4, Umeå University5, Pompeu Fabra University6, University of Melbourne7, Swiss Tropical and Public Health Institute8, Winterthur Museum, Garden and Library9, Ludwig Maximilian University of Munich10, University of Southampton11, University of Gothenburg12, Uppsala University13, Tartu University Hospital14, French Institute of Health and Medical Research15, University of Castilla–La Mancha16, University of Huelva17, Aarhus University18, University of Turin19, University of Pavia20, University of Paris21, University of Montpellier22, University of Grenoble23, University of Antwerp24, National Institutes of Health25, Imperial College London26
TL;DR: F Fathers’ smoking during early adolescence and grandmothers’ and mothers’smoking during pregnancy may independently increase asthma risk in offspring.
Abstract: Background: Mothers' smoking during pregnancy increases asthma risk in their offspring There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that
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TL;DR: A search for weakly interacting massive dark-matter particles produced in association with bottom or top quarks is presented and limits on the production cross-section of 300 times the predicted rate for mediators with masses between 10 and 50GeV are set.
Abstract: A search for weakly interacting massive dark matter particles produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and missing transverse ...
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TL;DR: In this article, a search for charged Higgs bosons heavier than the top quark and decaying via H± → tb is presented, which corresponds to 36.1 fb−1 of pp collisions at s=13 TeV.
Abstract: A search for charged Higgs bosons heavier than the top quark and decaying via H± → tb is presented. The data analysed corresponds to 36.1 fb−1 of pp collisions at s=13 TeV and was recorded with the ATLAS detector at the LHC in 2015 and 2016. The production of a charged Higgs boson in association with a top quark and a bottom quark, pp → tbH±, is explored in the mass range from mH± = 200 to 2000 GeV using multi-jet final states with one or two electrons or muons. Events are categorised according to the multiplicity of jets and how likely these are to have originated from hadronisation of a bottom quark. Multivariate techniques are used to discriminate between signal and background events. No significant excess above the background-only hypothesis is observed and exclusion limits are derived for the production cross-section times branching ratio of a charged Higgs boson as a function of its mass, which range from 2.9 pb at mH± = 200 GeV to 0.070 pb at mH± = 2000 GeV. The results are interpreted in two benchmark scenarios of the Minimal Supersymmetric Standard Model.[Figure not available: see fulltext.].
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University of Verona1, University of Turin2, University of Melbourne3, Pompeu Fabra University4, University of Iceland5, Ludwig Maximilian University of Munich6, University of Gothenburg7, Uppsala University8, National Institutes of Health9, Imperial College London10, French Institute of Health and Medical Research11, Paris Diderot University12, University of Sassari13, Haukeland University Hospital14, University of Bergen15, University of Pavia16, Charité17
TL;DR: Smoking initiation is still unacceptably high among European adolescents, and increasing rates among those aged 15 or less deserve attention, since youngsters are particularly vulnerable to nicotine addiction and tobacco adverse effects.
Abstract: Background Tobacco consumption is the largest avoidable health risk. Understanding changes of smoking over time and across populations is crucial to implementing health policies. We evaluated trends in smoking initiation between 1970 and 2009 in random samples of European populations. Methods We pooled data from six multicentre studies involved in the Ageing Lungs in European Cohorts consortium, including overall 119,104 subjects from 17 countries (range of median ages across studies: 33–52 years). We estimated retrospectively trends in the rates of smoking initiation (uptake of regular smoking) by age group, and tested birth cohort effects using Age-Period-Cohort (APC) modelling. We stratified all analyses by sex and region (North, East, South, West Europe). Results Smoking initiation during late adolescence (16–20 years) declined for both sexes and in all regions (except for South Europe, where decline levelled off after 1990). By the late 2000s, rates of initiation during late adolescence were still high (40–80 per 1000/year) in East, South, and West Europe compared to North Europe (20 per 1000/year). Smoking initiation rates during early adolescence (11–15 years) showed a marked increase after 1990 in all regions (except for North European males) but especially in West Europe, where they reached 40 per 1000/year around 2005. APC models supported birth cohort effects in the youngest cohorts. Conclusion Smoking initiation is still unacceptably high among European adolescents, and increasing rates among those aged 15 or less deserve attention. Reducing initiation in adolescents is fundamental, since youngsters are particularly vulnerable to nicotine addiction and tobacco adverse effects.
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University of Copenhagen1, Manchester Academic Health Science Centre2, University of Chicago3, University of La Laguna4, Carlos III Health Institute5, VU University Amsterdam6, University of Amsterdam7, Imperial College London8, National Institutes of Health9, Greifswald University Hospital10, University of Kiel11, University of Arizona12, Barcelona Supercomputing Center13, Technical University of Denmark14, Icahn School of Medicine at Mount Sinai15, University of California, San Francisco16, University of Southern California17, Swiss Tropical and Public Health Institute18, University of Basel19, Erasmus University Rotterdam20, University of Melbourne21, University of Liège22, Boston Children's Hospital23, University of Bristol24, Henry Ford Health System25, Ludwig Maximilian University of Munich26, Telethon Institute for Child Health Research27, Amgen28, University of Iceland29, University of Helsinki30, Karolinska Institutet31, Charité32, Max Delbrück Center for Molecular Medicine33, Harvard University34, Broad Institute35, University of Southern Denmark36, University of Newcastle37, Stockholm County Council38, Harry Perkins Institute of Medical Research39, Catalan Institution for Research and Advanced Studies40, Brigham and Women's Hospital41, QIMR Berghofer Medical Research Institute42, St George's, University of London43
TL;DR: In this article, the authors carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci.
Abstract: Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.
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Haukeland University Hospital1, Pompeu Fabra University2, Umeå University3, Ludwig Maximilian University of Munich4, Sahlgrenska University Hospital5, Paris Diderot University6, French Institute of Health and Medical Research7, Uppsala University8, Swiss Tropical and Public Health Institute9, University of Basel10, Aarhus University11, University of Pavia12, National Institutes of Health13, University of Bergen14
TL;DR: Women cleaning at home or working as occupational cleaners had accelerated decline in lung function, suggesting that exposures related to cleaning activities may constitute a risk to long‐term respiratory health.
Abstract: Rationale: Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional cl ...
01 Jan 2018
TL;DR: This paper performed two genome-wide association studies (GWASs) of circulating amounts of C-reactive protein (CRP) by using data from 88 studies comprising 204,402 European individuals.
Abstract: C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 10-8). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We identified 66 gene sets that were organized in two substantially correlated clusters, one mainly composed of immune pathways and the other characterized by metabolic pathways in the liver. Mendelian randomization analyses revealed a causal protective effect of CRP on schizophrenia and a risk-increasing effect on bipolar disorder. Our findings provide further insights into the biology of inflammation and could lead to interventions for treating inflammation and its clinical consequences.
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TL;DR: Evidence is provided that higher ambient AP levels increase the risk of mouth and throat cancer as well as of N MSC and that a higher residential green space level might have a protective effect for NMSC in areas with low to moderate UV intensity.
Abstract: There are a few epidemiological studies that (1) link increased ambient air pollution (AP) with an increase in lung cancer incidence rates and (2) investigate whether residing in green spaces could be protective against cancer. However, it is completely unclear whether other forms of cancer are also affected by AP and if residential green spaces could lower cancer incidence rates in general. Therefore, the objective was to estimate whether AP and green space are associated with several cancer types. The analysis was based on routine health care data from around 1.9 million people from Saxony who were free of cancer in 2008 and 2009. Incident cancer cases (2010–2014) of mouth and throat, skin (non-melanoma skin cancer - NMSC), prostate, breast, and colorectum were defined as: (1) one inpatient diagnosis, or (2) two outpatient diagnoses in two different quarters within one year and a specific treatment or death within two quarters after the diagnosis. Exposures, derived from freely available 3rd party data, included particulate matter with aerodynamic diameter of less than 10 μm (PM10) and nitrogen dioxide (N02) as well as green space (Normalized Difference Vegetation Index - NDVI). Associations between air pollutants, green space, and cancer incidence were assessed by multilevel Poisson models. Age, sex, physician contacts, short- and long-term unemployment, population density, and having an alcohol-related disorder were considered as potential confounders. Three thousand one hundred seven people developed mouth and throat cancer, 33,178 NMSC, 9611 prostate cancer, 9577 breast cancer, and 11,975 colorectal cancer during the follow-up period (2010–2014). An increase in PM10 of 10 μg/m3 was associated with a 53% increase in relative risk (RR) of mouth and throat cancer and a 52% increase in RR of NMSC. Prostate and breast cancer were modestly associated with PM10 with an increase in RR of 23 and 19%, respectively. The associations with N02 were in the same direction as PM10 but the effect estimates were much lower (7–24%). A 10% increase in NDVI was most protective of mouth and throat cancer (− 11% RR) and of NMSC (− 16% RR). Colorectal cancer was not affected by any of the exposures. In addition to the studies carried out so far, this study was able to provide evidence that higher ambient AP levels increase the risk of mouth and throat cancer as well as of NMSC and that a higher residential green space level might have a protective effect for NMSC in areas with low to moderate UV intensity. Nevertheless, we cannot rule out residual confounding by socioeconomic or smoking status.
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TL;DR: In this article, differential cross-sections of highly boosted pair-produced top quarks as a function of top-quark and t (t) over bar system kinematic observables using proton-proton collis...
Abstract: Measurements are made of differential cross-sections of highly boosted pair-produced top quarks as a function of top-quark and t (t) over bar system kinematic observables using proton-proton collis ...
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TL;DR: In this paper, measurements of ZZ production in the l(+)l(-)l'l'(+) l'(-) channel in proton-proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented.
Abstract: Measurements of ZZ production in the l(+)l(-)l'(+)l'(-) channel in proton-proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data correspond to 36.1 f ...
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TL;DR: Current evidence for an association between ambient ozone exposure and mental health outcomes is inconclusive and further high quality studies are needed to assess any potential links given the strong biologic plausibility.
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TL;DR: It is indicated that long-term exposure to PM1 may increase the risk of asthma and asthma-related symptoms, especially among boys and those with allergic predisposition.
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TL;DR: A search for massive coloured resonances which are pair-produced and decay into two jets is presented, interpreted in a SUSY simplified model where the lightest supersymmetric particle is the top squark, which decays promptly into two quarks through R-parity-violating couplings.
Abstract: A search for massive coloured resonances which are pair-produced and decay into two jets is presented. The analysis uses 36.7 fb(-1) of root s = 13 TeV pp collision data recorded by the ATLAS exper ...
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TL;DR: It is found that the correlation between the harmonic flow coefficients of charged particles in the pseudorapidity range measured in two separated η intervals does not factorise into the product of single-particle coefficients, and this breaking of factorisation, or flow decorrelation, increases linearly with the \eta $$η separation between the intervals.
Abstract: Measurements of longitudinal flow correlations are presented for charged particles in the pseudorapidity range vertical bar eta vertical bar < 2.4 using 7 mu b(-1) and 470 mu b(-1) of Pb+Pb coll ...