Kooresh I. Shoghi

TL;DR: The Human Tumor Atlas Network (HTAN), part of the NCI Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types.

TL;DR: It is demonstrated that PPARalpha and PPARbeta/delta drive distinct cardiac metabolic regulatory programs and PParbeta/ delta is identified as a potential target for metabolic modulation therapy aimed at cardiac dysfunction caused by diabetes and ischemia.

TL;DR: The results reveal a molecular mechanism by which lipid overload-induced mitochondrial ROS generation causes mitochondrial dysfunction by inducing post-translational modifications of mitochondrial proteins that regulate mitochondrial dynamics.

TL;DR: It is shown that EC CD36 acts as a gatekeeper for parenchymal cell FA uptake, with important downstream effects on glucose utilization and insulin action.

TL;DR: Using complementary techniques, it is reported that in vivo recruitment of NAc shell dynorphin neurons, acting through KOR, is necessary and sufficient to drive pain-induced negative affect and provides evidence that pain- induced adaptations in the kappa opioid system within theNAc shell represent a functional target for therapeutic intervention that could circumventPain-induced affective disorders.