Marc Jan Bonder

TL;DR: Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations, and proposed disease marker genera associated to host covariates were found associated to microbiota compositional variation with a 92% replication rate.

TL;DR: Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors, and an important step toward a better understanding of environment-diet-microbe-host interactions.

TL;DR: The differences between PPI users and non-users observed in this study are consistently associated with changes towards a less healthy gut microbiome, in line with known changes that predispose to C. difficile infections.

TL;DR: Validation of two predicted host-microbial interactions reveal that TNFα and IFNγ production are associated with specific microbial metabolic pathways: palmitoleic acid metabolism andtryptophan degradation to tryptophol.

TL;DR: In this article, the authors used epigenome-wide association to show that body mass index (BMI), a key measure of adiposity, is associated with widespread changes in DNA methylation.