N
Niek de Vries
Researcher at University of Amsterdam
Publications - 85
Citations - 8149
Niek de Vries is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Medicine & Rheumatoid arthritis. The author has an hindex of 29, co-authored 66 publications receiving 7140 citations. Previous affiliations of Niek de Vries include Academic Medical Center & VU University Amsterdam.
Papers
More filters
Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli A. Stahl,Soumya Raychaudhuri,Soumya Raychaudhuri,Elaine F. Remmers,Gang Xie,Stephen Eyre,Brian Thomson,Yonghong Li,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Alexandra Zhernakova,Anne Hinks,Candace Guiducci,Robert Chen,Lars Alfredsson,Christopher I. Amos,Kristin G. Ardlie,Anne Barton,John Bowes,Elisabeth Brouwer,Noël P. Burtt,Joseph J. Catanese,Jonathan S. Coblyn,Marieke J H Coenen,Karen H. Costenbader,Lindsey A. Criswell,J. Bart A. Crusius,Jing Cui,Paul I.W. de Bakker,Paul I.W. de Bakker,Philip L. De Jager,Philip L. De Jager,Bo Ding,Paul Emery,Edward Flynn,Pille Harrison,Lynne J. Hocking,Tom W J Huizinga,Daniel L. Kastner,Xiayi Ke,Annette Lee,Xiangdong Liu,Paul Martin,Ann W. Morgan,Leonid Padyukov,Marcel D. Posthumus,Timothy R D J Radstake,David M. Reid,Mark Seielstad,Michael F. Seldin,Nancy A. Shadick,Sophia Steer,Paul P. Tak,Wendy Thomson,Annette H M van der Helm-van Mil,Irene E. van der Horst-Bruinsma,C. Ellen van der Schoot,Piet L. C. M. van Riel,Michael E. Weinblatt,Anthony G. Wilson,Gertjan Wolbink,B. Paul Wordsworth,Cisca Wijmenga,Elizabeth W. Karlson,René E. M. Toes,Niek de Vries,Ann B. Begovich,Ann B. Begovich,Jane Worthington,Katherine A. Siminovitch,Peter K. Gregersen,Lars Klareskog,Robert M. Plenge,Robert M. Plenge +74 more
TL;DR: Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles.
Journal ArticleDOI
MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins.
Yuanjia Tang,Xiaobing Luo,Huijuan Cui,Xuming Ni,Min Yuan,Yanzhi Guo,Xinfang Huang,Haibo Zhou,Niek de Vries,Paul P. Tak,Shunle Chen,Nan Shen +11 more
TL;DR: Investigation of the contribution of microRNA-146a, identified in the pilot expression profiling step, to the pathogenesis of systemic lupus erythematosus revealed a negative regulator of innate immunity, which provides potential novel strategies for therapeutic intervention.
Journal ArticleDOI
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Elaine F. Remmers,Annette Lee,Rachel Hackett,Candace Guiducci,Noël P. Burtt,Lauren Gianniny,Benjamin D. Korman,Leonid Padyukov,Fina A S Kurreeman,Monica Chang,Joseph J. Catanese,Bo Ding,Sandra Wong,Annette H M van der Helm-van Mil,Benjamin M. Neale,Benjamin M. Neale,Benjamin M. Neale,Jonathan S. Coblyn,Jing Cui,Paul P. Tak,Gertjan Wolbink,J. Bart A. Crusius,Irene E. van der Horst-Bruinsma,Lindsey A. Criswell,Christopher I. Amos,Michael F. Seldin,Daniel L. Kastner,Kristin G. Ardlie,Lars Alfredsson,Karen H. Costenbader,David Altshuler,David Altshuler,Tom W J Huizinga,Nancy A. Shadick,Michael E. Weinblatt,Niek de Vries,Jane Worthington,Mark Seielstad,René E. M. Toes,Elizabeth W. Karlson,Ann B. Begovich,Lars Klareskog,Peter K. Gregersen,Mark J. Daly,Mark J. Daly,Robert M. Plenge,Robert M. Plenge,Robert M. Plenge +50 more
TL;DR: To identify rheumatoid arthritis risk loci in European populations, a meta-analysis of two published genome-wide association studies totaling 3,393 cases and 12,462 controls identified a common variant at the CD40 gene locus and identified evidence of association at four additional gene loci.
Journal ArticleDOI
New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study
François Cornelis,Sabine Fauré,Maria Martinez,Jean-François Prud'homme,P Fritz,Colette Dib,Helena Alves,Pilar Barrera,Niek de Vries,Alejandro Balsa,Dora Pascual-Salcedo,Kristin Maenaut,Rene Westhovens,Paola Migliorini,Tuyet-Hoa Tran,A Delaye,Nathalie Prince,Caroline Lefèvre,Gaëlle Thomas,Murielle Poirier,Stéphane Soubigou,Olivier Alibert,Sandra Lasbleiz,Sylvaine Fouix,Christiane Bouchier,Frédéric Lioté,Marie-Noëlle Loste,Virginia Lepage,Dominique Charron,Gabor Gyapay,A. Lopes-Vaz,D. Kuntz,Thomas Bardin,Jean Weissenbach +33 more
TL;DR: This first genome scan in RA Caucasian families revealed 14 candidate regions, one of which was supported further by the study of a second set of families, and could account for 16% of the genetic component of RA.