P
Pauline Schaap
Researcher at University of Dundee
Publications - 148
Citations - 5266
Pauline Schaap is an academic researcher from University of Dundee. The author has contributed to research in topics: Dictyostelium discoideum & Dictyostelium. The author has an hindex of 41, co-authored 141 publications receiving 4851 citations. Previous affiliations of Pauline Schaap include University of Groningen & Leiden University.
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Journal ArticleDOI
Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling
Mike Clarke,Amanda J. Lohan,Bernard A. Liu,Ilias Lagkouvardos,Scott William Roy,Nikhat Zafar,Claire Bertelli,Christina Schilde,Arash Kianianmomeni,Thomas R. Bürglin,Christian Frech,Bernard Turcotte,Klaus O. Kopec,John M. Synnott,Caleb Choo,Ivan A. Paponov,Aliza Finkler,Chris Soon Heng Tan,Andrew P. Hutchins,Thomas Weinmeier,Thomas Rattei,Jeffery Sc Chu,Gregory Gimenez,Manuel Irimia,Daniel J. Rigden,David A. Fitzpatrick,Jacob Lorenzo-Morales,Alex Bateman,Cheng-Hsun Chiu,Petrus Tang,Peter Hegemann,Hillel Fromm,Didier Raoult,Gilbert Greub,Diego Miranda-Saavedra,Nansheng Chen,Piers Nash,Michael L. Ginger,Matthias Horn,Pauline Schaap,Lis Caler,Brendan J. Loftus +41 more
TL;DR: In this paper, the authors present an analysis of a whole genome assembly of Acanthamoeba castellanii (Ac) the first representative from a solitary freeliving amoebozoan.
Journal ArticleDOI
Molecular Phylogeny and Evolution of Morphology in the Social Amoebas
Pauline Schaap,Thomas Winckler,Michaela Nelson,Elisa Alvarez-Curto,Barrie Elgie,Hiromitsu Hagiwara,James C. Cavender,Alicia Milano-Curto,Daniel E. Rozen,Theodor Dingermann,Rupert Mutzel,Sandra L. Baldauf +11 more
TL;DR: The first molecular phylogeny of the Dictyostelia is constructed with parallel small subunit ribosomal RNA and a-tubulin data sets, and it is found that dictyostelid taxonomy requires complete revision.
Journal ArticleDOI
Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum
Richard Sucgang,Alan Kuo,Xiangjun Tian,William J Salerno,Anup Parikh,Christa L. Feasley,Eileen Dalin,Hank Tu,Eryong Huang,Kerrie Barry,Erika Lindquist,Harris Shapiro,David G Bruce,Jeremy Schmutz,Asaf Salamov,Petra Fey,Pascale Gaudet,Christophe Anjard,M. Madan Babu,S. Basu,Yulia A. Bushmanova,Hanke van der Wel,Mariko Katoh-Kurasawa,Christopher Dinh,Pedro M. Coutinho,Tamao Saito,Marek Eliáš,Pauline Schaap,Robert R. Kay,Bernard Henrissat,Ludwig Eichinger,Francisco Rivero,Nicholas H. Putnam,Christopher M. West,William F. Loomis,Rex L. Chisholm,Gad Shaulsky,Gad Shaulsky,Joan E. Strassmann,David C. Queller,Adam Kuspa,Adam Kuspa,Igor V. Grigoriev +42 more
TL;DR: Genes involved in the social stage evolved more rapidly than others, consistent with either relaxed selection or accelerated evolution due to social conflict, and shed light on the biology and evolution of the Dictyostelia.
Journal ArticleDOI
Induction of post-aggregative differentiation in Dictyostelium discoideum by cAMP: evidence of involvement of the cell surface cAMP receptor
Pauline Schaap,Roel van Driel +1 more
TL;DR: In this article, the cyclic nucleotide specificity, the effect of modulation of the cAMP signal and the dose-response relationship of the induction of two independent markers of post-aggregative differentiation, i.e., a prespore cell-specific antigen detected by a monoclonal antibody, were analyzed.
Journal ArticleDOI
Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication
Andrew J. Heidel,Hajara M. Lawal,Marius Felder,Christina Schilde,Nicholas R. Helps,Budi Tunggal,Francisco Rivero,Uwe John,Michael Schleicher,Ludwig Eichinger,Matthias Platzer,Angelika A. Noegel,Pauline Schaap,Gernot Glöckner,Gernot Glöckner,Gernot Glöckner +15 more
TL;DR: Phylogenetic dating using a concatenated data set and extensive loss of synteny indicate that DF, PP, and DD split from their last common ancestor at least 0.6 billion years ago.