M
Meixia Ren
Researcher at Fujian Medical University
Publications - 21
Citations - 1752
Meixia Ren is an academic researcher from Fujian Medical University. The author has contributed to research in topics: Genome-wide association study & Blood pressure. The author has an hindex of 11, co-authored 18 publications receiving 1173 citations. Previous affiliations of Meixia Ren include National Institute for Health Research & Queen Mary University of London.
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Journal ArticleDOI
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelos Evangelou,Evangelos Evangelou,Helen R. Warren,Helen R. Warren,David Mosen-Ansorena,Borbala Mifsud,Raha Pazoki,He Gao,Georgios Ntritsos,Niki Dimou,Claudia P. Cabrera,Claudia P. Cabrera,Ibrahim Karaman,Fu Liang Ng,Marina Evangelou,K. Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Yan V. Sun,Kelly Cho,Kelly Cho,J. Michael Gaziano,J. Michael Gaziano,Peter W.F. Wilson,Philip S. Tsao,Csaba P. Kovesdy,Tõnu Esko,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,Franco Giulianini,Elizabeth G. Holliday,Anne U. Jackson,Ruifang Li-Gao,Wei-Yu Lin,Jian'an Luan,Massimo Mangino,Massimo Mangino,Christopher Oldmeadow,Bram P. Prins,Yong Qian,Muralidharan Sargurupremraj,Nabi Shah,Nabi Shah,Praveen Surendran,Sébastien Thériault,Sébastien Thériault,Niek Verweij,Niek Verweij,Niek Verweij,Sara M. Willems,Jing Hua Zhao,Philippe Amouyel,John M. C. Connell,Renée de Mutsert,Alex S. F. Doney,Martin Farrall,Martin Farrall,Cristina Menni,Andrew D. Morris,Raymond Noordam,Guillaume Paré,Neil Poulter,Denis C. Shields,Alice Stanton,Simon Thom,Gonçalo R. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,Kristin L. Ayers,Caterina Barbieri,Chiara Batini,Joshua C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Dorret I. Boomsma,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Gail Davies,Martin H. de Borst,Eco J. C. de Geus,Ian J. Deary,Joris Deelen,Fabiola Del Greco M,Cumhur Y Demirkale,Marcus Dörr,Georg Ehret,Georg Ehret,Roberto Elosua,Stefan Enroth,A. Mesut Erzurumluoglu,Teresa Ferreira,Mattias Frånberg,Mattias Frånberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Anuj Goel,Anuj Goel,Alan J. Gow,Alan J. Gow,Vilmundur Gudnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Aki S. Havulinna,Andrew A. Hicks,Edith Hofer,Albert Hofman,Albert Hofman,Jouke-Jan Hottenga,Jennifer E. Huffman,Jennifer E. Huffman,Shih-Jen Hwang,Erik Ingelsson,Erik Ingelsson,Alan James,Alan James,Rick Jansen,Marjo-Riitta Järvelin,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Sekar Kathiresan,Sekar Kathiresan,Bernard Keavney,Bernard Keavney,Kay-Tee Khaw,Paul Knekt,Joanne Knight,Ivana Kolcic,Jaspal S. Kooner,Seppo Koskinen,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Maris Laan,Marty Larson,Lenore J. Launer,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Li Lin,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Yongmei Liu,Ruth J. F. Loos,Ruth J. F. Loos,Lorna M. Lopez,Lorna M. Lopez,Lorna M. Lopez,Yingchang Lu,Leo-Pekka Lyytikäinen,Anubha Mahajan,Chrysovalanto Mamasoula,Jaume Marrugat,Jonathan Marten,Yuri Milaneschi,Anna Morgan,Andrew P. Morris,Andrew P. Morris,Alanna C. Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Christopher P. Nelson,Teemu J. Niiranen,Teemu J. Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Paul F. O'Reilly,Elin Org,Sandosh Padmanabhan,Sandosh Padmanabhan,Walter Palmas,Aarno Palotie,Aarno Palotie,Aarno Palotie,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Quang Tri Nguyen,Olli T. Raitakari,Olli T. Raitakari,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M. Ridker,Paul M. Ridker,Janina S. Ried,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Jerome I. Rotter,Igor Rudan,Daniela Ruggiero,Yasaman Saba,Cinzia Sala,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Antti-Pekka Sarin,Reinhold Schmidt,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert V. Smith,Harold Snieder,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Maciej Tomaszewski,Maciej Tomaszewski,Daniela Toniolo,Michela Traglia,Stella Trompet,Jaakko Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Ahmad Vaez,Peter J. van der Most,Cornelia M. van Duijn,Anne-Claire Vergnaud,Germaine C. Verwoert,Veronique Vitart,Uwe Völker,Peter Vollenweider,Dragana Vuckovic,Dragana Vuckovic,Hugh Watkins,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weihua Zhang,Weihua Zhang,John Attia,Adam S. Butterworth,Adam S. Butterworth,Daniel I. Chasman,Daniel I. Chasman,David Conen,David Conen,Francesco Cucca,Francesco Cucca,John Danesh,John Danesh,Caroline Hayward,Joanna M. M. Howson,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Olle Melander,Dennis O. Mook-Kanamori,Colin N. A. Palmer,Lorenz Risch,Robert A. Scott,Rodney J. Scott,Peter S. Sever,Tim D. Spector,Pim van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Daniel Levy,Patricia B. Munroe,Patricia B. Munroe,Christopher Newton-Cheh,Christopher Newton-Cheh,Morris J. Brown,Morris J. Brown,Andres Metspalu,Adriana M. Hung,Christopher J. O'Donnell,Todd L. Edwards,Bruce M. Psaty,Bruce M. Psaty,Ioanna Tzoulaki,Ioanna Tzoulaki,Michael R. Barnes,Michael R. Barnes,Louise V. Wain,Louise V. Wain,Paul Elliott,Mark J. Caulfield,Mark J. Caulfield +341 more
TL;DR: In this article, the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry was conducted.
Journal ArticleDOI
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Helen R. Warren,Evangelos Evangelou,Evangelos Evangelou,Claudia P. Cabrera,He Gao,Meixia Ren,Meixia Ren,Borbala Mifsud,Ioanna Ntalla,Praveen Surendran,Chunyu Liu,James P. Cook,Aldi T. Kraja,Fotios Drenos,Fotios Drenos,Marie Loh,Marie Loh,Niek Verweij,Niek Verweij,Jonathan Marten,Ibrahim Karaman,Marcelo P. Segura Lepe,Marcelo P. Segura Lepe,Paul F. O'Reilly,Joanne Knight,Harold Snieder,Norihiro Kato,Jiang He,E. Shyong Tai,M. Abdullah Said,David J. Porteous,Maris Alver,Neil Poulter,Martin Farrall,Ron T. Gansevoort,Sandosh Padmanabhan,Reedik Mägi,Alice Stanton,John M. C. Connell,Stephan J. L. Bakker,Andres Metspalu,Denis C. Shields,Simon Thom,Morris Brown,Peter S. Sever,Tõnu Esko,Tõnu Esko,Caroline Hayward,Pim van der Harst,Danish Saleheen,Danish Saleheen,Rajiv Chowdhury,John C. Chambers,Daniel I. Chasman,Aravinda Chakravarti,Christopher Newton-Cheh,Christopher Newton-Cheh,Cecilia M. Lindgren,Daniel Levy,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Bernard Keavney,Bernard Keavney,Maciej Tomaszewski,Maciej Tomaszewski,Nilesh J. Samani,Nilesh J. Samani,Joanna M. M. Howson,Martin D. Tobin,Patricia B. Munroe,Patricia B. Munroe,Georg Ehret,Georg Ehret,Louise V. Wain +74 more
TL;DR: In this paper, the authors report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci.
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Helen R. Warren,Evangelos Evangelou,Claudia P. Cabrera,He Gao,Meixia Ren,Borbala Mifsud,Ioanna Ntalla,Praveen Surendran,Chunyu Liu,James P. Cook,Aldi T. Kraja,Fotios Drenos,Marie Loh,Niek Verweij,Jonathan Marten,Ibrahim Karaman,Marcelo P. Segura Lepe,Paul F. O'Reilly,Joanne Knight,Harold Snieder,Norihiro Kato,Jiang He,E. Shyong Tai,M. Abdullah Said,David J. Porteous,Maris Alver,Neil Poulter,Martin Farrall,Ron T. Gansevoort,Sandosh Padmanabhan,Reedik Mägi,Alice Stanton,John M. C. Connell,Stephan J. L. Bakker,Andres Metspalu,Denis C. Shields,Simon Thom,Morris Brown,Peter S. Sever,Tõnu Esko,Caroline Hayward,Pim van der Harst,Danish Saleheen,Rajiv Chowdhury,John C. Chambers,Daniel I. Chasman,Aravinda Chakravarti,Christopher Newton-Cheh,Cecilia M. Lindgren,Daniel Levy,Jaspal S. Kooner,Bernard Keavney,Maciej Tomaszewski,Nilesh J. Samani,Joanna M. M. Howson,Martin D. Tobin,Patricia B. Munroe,Georg Ehret,Louise V. Wain,Michael R. Barnes,Joanna Tzoulaki,Mark J. Caulfield,Paul Elliott,Ahmad Vaez,Rick Jansen,Roby Joehanes,Peter J. van der Most,A. Mesut Erzurumluoglu,Paul O'Reilly,Lynda M. Rose,Germaine C. Verwoert,Jouke-Jan Hottenga,Rona J. Strawbridge,Dan E. Arking,Shih-Jen Hwang,Xiuqing Guo,Zoltán Kutalik,Stella Trompet,Nick Shrine,Alexander Teumer,Janina S. Ried,Joshua C. Bis,Albert V. Smith,Najaf Amin,Ilja M. Nolte,Leo-Pekka Lyytikäinen,Anubha Mahajan,Nicholas J. Wareham,Edith Hofer,Peter K. Joshi,Kati Kristiansson,Michela Traglia,Aki S. Havulinna,Anuj Goel,Mike A. Nalls,Siim Sõber,Dragana Vuckovic,Jian'an Luan,Fabiola Del Greco M,Kristin L. Ayers,Jaume Marrugat,Daniela Ruggiero,Lorna M. Lopez,Teemu J. Niiranen,Stefan Enroth,Anne U. Jackson,Christopher P. Nelson,Jennifer E. Huffman,Weihua Zhang,Ilaria Gandin,Sarah E. Harris,Tatijana Zemonik,Yingchang Lu,Nabi Shah,Martin H. de Borst,Massimo Mangino,Bram P. Prins,Archie Campbell,Ruifang Li-Gao,Ganesh Chauhan,Christopher Oldmeadow,Gonçalo R. Abecasis,Maryam Abedi,Caterina Barbieri,Chiara Batini,Tineka Blake,Michael Boehnke,Erwin P. Bottinger,Peter S. Braund,Marco Brumat,Harry Campbell,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Jeffrey Damman,Gail Davies,Eco J. C. de Geus,Renée de Mutsert,Joris Deelen,Yusuf Demirkale,Alex S. F. Doney,Marcus Dörr,Teresa Ferreira,Mattias Frånberg,Vilmantas Giedraitis,Christian Gieger,Franco Giulianini,Alan J. Gow,Anders Hamsten,Tamara B. Harris,Albert Hofman,Elizabeth G. Holliday,Marjo-Riitta Järvelin,Åsa Johansson,Andrew D. Johnson,Pekka Jousilahti,Antti Jula,Mika Kähönen,Sekar Kathiresan,Kay-Tee Khaw,Ivana Kolcic,Seppo Koskinen,Claudia Langenberg,Marty Larson,Lenore J. Launer,Benjamin Lehne,David C. Liewald,Li Lin,Lars Lind,François Mach,Chrysovalanto Mamasoula,Cristina Menni,Yuri Milaneschi,Anna Morgan,Andrew D. Morris,Alanna C. Morrison,Peter J. Munson,Priyanka Nandakumar,Quang Tri Nguyen,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Elin Org,Aarno Palotie,Guillaume Paré,Alison Pattie,Brenda W.J.H. Penninx,Peter P. Pramstaller,Olli T. Raitakari,Kenneth Rice,Paul M. Ridker,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Jerome I. Rotter,Igor Rudan,Yasaman Saba,Aude Saint Pierre,Cinzia Sala,Antti-Pekka Sarin,Reinhold Schmidt,Rodney J. Scott,Marc A. Seelen,David S. Siscovick,Rossella Sorice,David J. Stott,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Ioanna Tzoulaki,Christophe Tzourio,André G. Uitterlinden,Uwe Völker,Peter Vollenweider,Sarah H. Wild,Gonneke Willemsen,Alan F. Wright,Jie Yao,Sébastien Thériault,David Conen,Attia John,Stéphanie Debette,Dennis O. Mook-Kanamori,Eleftheria Zeggini,Tim D. Spector,Colin N. A. Palmer,Anne-Claire Vergnaud,Ruth J. F. Loos,Ozren Polasek,John M. Starr,Giorgia Girotto,C M Lindgren,Veronique Vitart,Jaakko Tuomilehto,Ulf Gyllensten,Paul Knekt,Ian J. Deary,Marina Ciullo,Roberto Elosua,Bernard Keavney,Andrew A. Hicks,Robert A. Scott,Paolo Gasparini,Maris Laan,Yongmei Liu,Hugh Watkins,Catharina A. Hartman,Veikko Salomaa,Daniela Toniolo,Markus Perola,James F. Wilson,Helena Schmidt,Jing Hua Zhao,Terho Lehtimäki,Cornelia M. van Duijn,Vilmundur Gudnason,Bruce M. Psaty,Annette Peters,Rainer Rettig,Alan James,J. Wouter Jukema,David P. Strachan,Walter Palmas,Erik Ingelsson,Dorret I. Boomsma,Oscar H. Franco,Murielle Bochud,Andrew P. Morris +267 more
TL;DR: Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.
Journal ArticleDOI
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney
Louise V. Wain,Ahmad Vaez,Rick Jansen,Roby Joehanes,Roby Joehanes,Peter J. van der Most,A. Mesut Erzurumluoglu,Paul F. O'Reilly,Claudia P. Cabrera,Helen R. Warren,Lynda M. Rose,Germaine C. Verwoert,Jouke-Jan Hottenga,Rona J. Strawbridge,Tõnu Esko,Tõnu Esko,Dan E. Arking,Shih-Jen Hwang,Xiuqing Guo,Zoltán Kutalik,Zoltán Kutalik,Stella Trompet,Nick Shrine,Alexander Teumer,Janina S. Ried,Joshua C. Bis,Albert V. Smith,Najaf Amin,Ilja M. Nolte,Leo-Pekka Lyytikäinen,Anubha Mahajan,Nicholas J. Wareham,Edith Hofer,Peter K. Joshi,Kati Kristiansson,Michela Traglia,Aki S. Havulinna,Anuj Goel,Anuj Goel,Mike A. Nalls,Siim Sõber,Dragana Vuckovic,Jian'an Luan,Fabiola M. Del Greco,Kristin L. Ayers,Jaume Marrugat,Daniela Ruggiero,Lorna M. Lopez,Teemu J. Niiranen,Stefan Enroth,Anne U. Jackson,Christopher P. Nelson,Christopher P. Nelson,Jennifer E. Huffman,Weihua Zhang,Jonathan Marten,Ilaria Gandin,Sarah E. Harris,Tatijana Zemunik,Yingchang Lu,Evangelos Evangelou,Nabi Shah,Nabi Shah,Martin H. de Borst,Massimo Mangino,Massimo Mangino,Bram P. Prins,Archie Campbell,Ruifang Li-Gao,Ganesh Chauhan,Christopher Oldmeadow,Gonçalo R. Abecasis,Maryam Abedi,Caterina Barbieri,Michael R. Barnes,Chiara Batini,John Beilby,Tineka Blake,Michael Boehnke,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Morris Brown,Marco Brumat,Harry Campbell,John C. Chambers,John C. Chambers,Massimiliano Cocca,Francis S. Collins,John M. C. Connell,Heather J. Cordell,Jeffrey Damman,Gail Davies,Eco J. C. de Geus,Renée de Mutsert,Joris Deelen,Yusuf Demirkale,Alex S. F. Doney,Marcus Dörr,Martin Farrall,Martin Farrall,Teresa Ferreira,Mattias Frånberg,Mattias Frånberg,He Gao,Vilmantas Giedraitis,Christian Gieger,Franco Giulianini,Alan J. Gow,Anders Hamsten,Tamara B. Harris,Albert Hofman,Elizabeth G. Holliday,Jennie Hui,Marjo-Riitta Järvelin,Åsa Johansson,Andrew D. Johnson,Pekka Jousilahti,Antti Jula,Mika Kähönen,Sekar Kathiresan,Kay-Tee Khaw,Ivana Kolcic,Seppo Koskinen,Claudia Langenberg,Marty Larson,Lenore J. Launer,Benjamin Lehne,David C. Liewald,Li Lin,Lars Lind,François Mach,Chrysovalanto Mamasoula,Cristina Menni,Borbala Mifsud,Yuri Milaneschi,Anna Morgan,Andrew D. Morris,Alanna C. Morrison,Peter J. Munson,Priyanka Nandakumar,Quang Tri Nguyen,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Elin Org,Sandosh Padmanabhan,Aarno Palotie,Guillaume Paré,Alison Pattie,Brenda W.J.H. Penninx,Neil Poulter,Peter P. Pramstaller,Olli T. Raitakari,Meixia Ren,Meixia Ren,Kenneth Rice,Paul M. Ridker,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Jerome I. Rotter,Igor Rudan,Yasaman Saba,Aude Saint Pierre,Cinzia Sala,Antti-Pekka Sarin,Reinhold Schmidt,Rodney J. Scott,Rodney J. Scott,Marc A. Seelen,Denis C. Shields,David S. Siscovick,Rossella Sorice,Alice Stanton,David J. Stott,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Simon Thom,Ioanna Tzoulaki,Christophe Tzourio,Christophe Tzourio,André G. Uitterlinden,Uwe Völker,Peter Vollenweider,Sarah H Wild,Gonneke Willemsen,Alan F. Wright,Jie Yao,Sébastien Thériault,David Conen,John Attia,John Attia,Peter S. Sever,Stéphanie Debette,Stéphanie Debette,Dennis O. Mook-Kanamori,Eleftheria Zeggini,Tim D. Spector,Pim van der Harst,Colin N. A. Palmer,Anne-Claire Vergnaud,Ruth J. F. Loos,Ruth J. F. Loos,Ozren Polasek,John M. Starr,Giorgia Girotto,Caroline Hayward,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,C M Lindgren,C M Lindgren,Veronique Vitart,Nilesh J. Samani,Nilesh J. Samani,Jaakko Tuomilehto,Ulf Gyllensten,Paul Knekt,Ian J. Deary,Marina Ciullo,Roberto Elosua,Bernard Keavney,Andrew A. Hicks,Robert A. Scott,Paolo Gasparini,Maris Laan,Yongmei Liu,Hugh Watkins,Hugh Watkins,Catharina A. Hartman,Veikko Salomaa,Daniela Toniolo,Markus Perola,Markus Perola,James F. Wilson,Helena Schmidt,Jing Hua Zhao,Terho Lehtimäki,Cornelia M. van Duijn,Vilmundur Gudnason,Bruce M. Psaty,Annette Peters,Rainer Rettig,Alan James,Alan James,J. Wouter Jukema,David P. Strachan,Walter Palmas,Andres Metspalu,Erik Ingelsson,Erik Ingelsson,Dorret I. Boomsma,Oscar H. Franco,Murielle Bochud,Christopher Newton-Cheh,Christopher Newton-Cheh,Patricia B. Munroe,Paul Elliott,Daniel I. Chasman,Aravinda Chakravarti,Joanne Knight,Andrew P. Morris,Andrew P. Morris,Daniel Levy,Martin D. Tobin,Harold Snieder,Mark J. Caulfield,Georg Ehret,Georg Ehret +270 more
TL;DR: 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources are identified and these robustly implicated genes may provide new leads for therapeutic innovation.
Journal ArticleDOI
Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction
Wei Yang,Fu Liang Ng,Kenneth Chan,Kenneth Chan,Xiangyuan Pu,Xiangyuan Pu,Robin N. Poston,Meixia Ren,Weiwei An,Ruoxin Zhang,Jingchun Wu,Shunying Yan,Haiteng Situ,Xinjie He,Yequn Chen,Xuerui Tan,Qingzhong Xiao,Arthur Tucker,Mark J. Caulfield,Shu Ye +19 more
TL;DR: Results indicate that the CHD-related genetic variant at the COL4A2 locus affects COL4 a2/COL4A1 expression, SMC survival, and atherosclerotic plaque stability, providing a mechanistic explanation for the association between the genetic variant and CHD risk.