Leibniz University of Hanover

About: Leibniz University of Hanover is a education organization based out in Hanover, Niedersachsen, Germany. It is known for research contribution in the topics: Finite element method & Computer science. The organization has 14283 authors who have published 29845 publications receiving 682152 citations.

Bits and Pieces in Logarithmic Conformal Field Theory

Abstract: These are notes of my lectures held at the first School & Workshop on Logarithmic Conformal Field Theory and its Applications, September 2001 in Tehran, Iran. These notes cover only selected parts of the by now quite extensive knowledge on logarithmic conformal field theories. In particular, I discuss the proper generalization of null vectors towards the logarithmic case, and how these can be used to compute correlation functions. My other main topic is modular invariance, where I discuss the problem of the generalization of characters in the case of indecomposable representations, a proposal for a Verlinde formula for fusion rules and identities relating the partition functions of logarithmic conformal field theories to such of well known ordinary conformal field theories. The two main topics are complemented by some remarks on ghost systems, the Haldane-Rezayi fractional quantum Hall state, and the relation of these two to the logarithmic c=-2 theory.

Long-Chain Omega-3 Fatty Acids Improve Brain Function and Structure in Older Adults

Abstract: Higher intake of seafish or oil rich in long-chain omega-3 polyunsaturated fatty acids (LC-n3-FA) may be beneficial for the aging brain. We tested in a prospective interventional design whether high levels of supplementary LC-n3-FA would improve cognition, and addressed potential mechanisms underlying the effects. Sixty-five healthy subjects (50-75 years, 30 females) successfully completed 26 weeks of either fish oil (2.2 g/day LC-n3-FA) or placebo intake. Before and after the intervention period, cognitive performance, structural neuroimaging, vascular markers, and blood parameters were assayed. We found a significant increase in executive functions after LC-n3-FA compared with placebo (P = 0.023). In parallel, LC-n3-FA exerted beneficial effects on white matter microstructural integrity and gray matter volume in frontal, temporal, parietal, and limbic areas primarily of the left hemisphere, and on carotid intima media thickness and diastolic blood pressure. Improvements in executive functions correlated positively with changes in omega-3-index and peripheral brain-derived neurotrophic factor, and negatively with changes in peripheral fasting insulin. This double-blind randomized interventional study provides first-time evidence that LC-n3-FA exert positive effects on brain functions in healthy older adults, and elucidates underlying mechanisms. Our findings suggest novel strategies to maintain cognitive functions into old age.

All AdS7 solutions of type II supergravity

Abstract: In M-theory, the only AdS7 supersymmetric solutions are AdS7�S 4 and its orbifolds. In this paper, wend and classify new supersymmetric solutions of the type AdS7� M3 in type II supergravity. While in IIB none exist, in IIA with Romans mass (which does not lift to M-theory) there are many new ones. We use a pure spinor approach reminiscent of generalized complex geometry. Without the need for any Ansatz, the system determines uniquely the form of the metric and uxes, up to solving a system of ODEs. Namely, the metric on M3 is that of an S 2 �bered over an interval; this is consistent with the Sp(1) R-symmetry of the holographically dual (1,0) theory. By including D8 brane sources, one can numerically obtain regular solutions, where topologically M3 � S 3 .

Personalization in distributed e-learning environments

Abstract: Personalized support for learners becomes even more important, when e-Learning takes place in open and dynamic learning and information networks. This paper shows how to realize personalized learning support in distributed learning environments based on Semantic Web technologies. Our approach fills the existing gap between current adaptive educational systems with well-established personalization functionality, and open, dynamic learning repository networks. We propose a service-based architecture for establishing personalized e-Learning, where personalization functionality is provided by various web-services. A Personal Learning Assistant integrates personalization services and other supporting services, and provides the personalized access to learning resources in an e-Learning network.

A systematic review on the diagnosis and treatment of primary (idiopathic) dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force

Abstract: To review the literature on primary dystonia and dystonia plus and to provide evidence-based recommendations. Primary dystonia and dystonia plus are chronic and often disabling conditions with a widespread spectrum mainly in young people. Computerized MEDLINE and EMBASE literature reviews (1966-1967 February 2005) were conducted. The Cochrane Library was searched for relevant citations. Diagnosis and classification of dystonia are highly relevant for providing appropriate management and prognostic information, and genetic counselling. Expert observation is suggested. DYT-1 gene testing in conjunction with genetic counselling is recommended for patients with primary dystonia with onset before age 30 years and in those with an affected relative with early onset. Positive genetic testing for dystonia (e.g. DYT-1) is not sufficient to make diagnosis of dystonia. Individuals with myoclonus should be tested for the epsilon-sarcoglycan gene (DYT-11). A levodopa trial is warranted in every patient with early onset dystonia without an alternative diagnosis. Brain imaging is not routinely required when there is a confident diagnosis of primary dystonia in adult patients, whereas it is necessary in the paediatric population. Botulinum toxin (BoNT) type A (or type B if there is resistance to type A) can be regarded as first line treatment for primary cranial (excluding oromandibular) or cervical dystonia and can be effective in writing dystonia. Actual evidence is lacking on direct comparison of the clinical efficacy and safety of BoNT-A vs. BoNT-B. Pallidal deep brain stimulation (DBS) is considered a good option, particularly for generalized or cervical dystonia, after medication or BoNT have failed to provide adequate improvement. Selective peripheral denervation is a safe procedure that is indicated exclusively in cervical dystonia. Intrathecal baclofen can be indicated in patients where secondary dystonia is combined with spasticity. The absolute and comparative efficacy and tolerability of drugs in dystonia, including anticholinergic and antidopaminergic drugs, is poorly documented and no evidence-based recommendations can be made to guide prescribing.