Lund University

About: Lund University is a education organization based out in Lund, Sweden. It is known for research contribution in the topics: Population & Cancer. The organization has 42345 authors who have published 124676 publications receiving 5016438 citations. The organization is also known as: Lunds Universitet & University of Lund.

How does control timing affect performance? Analysis and simulation of timing using Jitterbug and TrueTime

Abstract: To achieve good performance in systems with limited computer resources, the constraints of the implementation platform must be taken into account at design time. To facilitate this, software tools are needed to analyze and simulate how timing affects control performance. This article describes two such tools: Jitterbug and TrueTime.

Marker band in one chromosome 14 from Burkitt lymphomas.

Abstract: KNOWLEDGE of the detailed pattern of fluorescence of the normal human karyotype, showing more than 200 bands per haploid chromosome set1, has enabled us to recognize, both in biopsies and in cell cultures from several Burkitt lymphomas, an extra band in one homologue of D group chromosome pair No. 14. The deviation was seen in all analysable cells of five out of six tumour biopsies and of seven out of nine tumour cell lines examined, representing twelve different tumours from nine male and three female patients. In three tumours both biopsies and cultures were examined, and it was found that all gave results consistent in the two types of samples. Thus, two of them had the marker band in both the biopsy and culture, the third revealed the marker band absent in both cases. The remaining tumours were investigated only in biopsies or only in culture. They were positive in eight cases, negative in one. Of the twelve tumours examined altogether, ten were positive and two negative.

Free radicals and brain damage

Abstract: Although free radicals have been suggested to contribute to ischemic brain damage for more than 10 years, it is not until quite recently that convincing evidence has been presented for their involvement in both sustained and transient ischemia. The hypothesis is examined against current knowledge of free radical chemistry, as it applies to biological systems, and of cellular iron metabolism. It is emphasized that those advents have changed our outlook on free radical-induced tissue damage. First, it has been realized that damage to DNA and proteins may be an earlier event than lipid peroxidation, perhaps also a more important one. Second, evidence now exists that the triggering event in free radical-induced damage is a disturbance of cellular iron metabolism, notably delocalization of protein-bound iron, and its chelation by compounds that trigger site-specific free radical damage. Third, methods have been developed that allow the demonstration of partially induced oxygen species in tissues, and scavengers have become available that can curb free radical reactions. As a result of these events, it has been possible to demonstrate formation of free radicals in oxygen toxicity, trauma, and ischemia, and their participation in the cell damage that is incurred in these conditions, particularly in causing vascular pathology and edema. It is suggested that in ischemia, free radical damage becomes pathogenetically important when the ischemia is of long duration, when conditions favor continued delivery of some oxygen to the ischemic tissue, and particularly when such partially oxygen-deprived tissue is reoxygenated.