Institution
Lund University
Education•Lund, Sweden•
About: Lund University is a education organization based out in Lund, Sweden. It is known for research contribution in the topics: Population & Cancer. The organization has 42345 authors who have published 124676 publications receiving 5016438 citations. The organization is also known as: Lunds Universitet & University of Lund.
Topics: Population, Cancer, Insulin, Breast cancer, Diabetes mellitus
Papers published on a yearly basis
Papers
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Wellcome Trust Centre for Human Genetics1, Medical Research Council2, Broad Institute3, Harvard University4, Wellcome Trust Sanger Institute5, King's College London6, deCODE genetics7, Boston University8, University of Michigan9, Erasmus University Rotterdam10, National Institutes of Health11, VU University Amsterdam12, University of Oulu13, Lund University14, University of Virginia15, University Hospital of Lausanne16, University of Lausanne17, University of Southern California18, Imperial College London19, Ninewells Hospital20, University of California, Los Angeles21, University of Düsseldorf22, Novartis23, Swiss Institute of Bioinformatics24, European Bioinformatics Institute25, University of Eastern Finland26, GlaxoSmithKline27, University of North Carolina at Chapel Hill28, Oulu University Hospital29, University Medical Center Groningen30, University of Helsinki31, Ludwig Maximilian University of Munich32, University of Cambridge33, VU University Medical Center34, Leiden University Medical Center35, Brigham and Women's Hospital36, Massachusetts Institute of Technology37, University of Iceland38, University of Oxford39
TL;DR: Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten genome-wide association scans, and previous associations of fasting glucose with variants at the G6PC2 and GCK loci are confirmed.
Abstract: To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10(-15)). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 x 10(-7)) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci.
716 citations
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TL;DR: It is shown that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self‐repair strategies to improve recovery after stroke.
Abstract: Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-1alpha and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke.
716 citations
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TL;DR: The results confirm that significant evolution of the corona occurs in the second biological solution, but that the final corona contains a "fingerprint" of its history, which could be evolved to map the transport pathways utilized by nanoparticles, and eventually to predict nanoparticle fate and behavior.
Abstract: The importance of the protein corona formed around nanoparticles upon entering a biological fluid has recently been highlighted. This corona is, when sufficiently long-lived, thought to govern the particles’ biological fate. However, even this long-lived “hard” corona evolves and re-equilibrates as particles pass from one biological fluid to another, and may be an important feature for long-term fate. Here we show the evolution of the protein corona as a result of transfer of nanoparticles from one biological fluid (plasma) into another (cytosolic fluid), a simple illustrative model for the uptake of nanoparticles into cells. While no direct comparison can be made to what would happen in, for example, the uptake pathway, the results confirm that significant evolution of the corona occurs in the second biological solution, but that the final corona contains a “fingerprint” of its history. This could be evolved to map the transport pathways utilized by nanoparticles, and eventually to predict nanoparticle f...
716 citations
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TL;DR: This account of chronic venous disease summarizes the clinical aspects of the disorder and reviews the recent advances in studies of the hydrodynamic and biochemical changes that underlie the disorder.
Abstract: This account of chronic venous disease summarizes the clinical aspects of the disorder and reviews the recent advances in studies of the hydrodynamic and biochemical changes that underlie the disorder.
715 citations
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TL;DR: In this paper, three principles of feminist research are identified: research should contribute to women's liberation through producing knowledge that can be used by women themselves; use methods of gaining knowledge that are not oppressive; should continually develop a feminist critical perspective that questions dominant intellectual traditions and can reflect on its own development.
Abstract: This paper examines principles of feminist research and discusses the authors' attempts to use these principles in a systematic way in their own research. Three principles of feminist research are identified: research should contribute to women's liberation through producing knowledge that can be used by women themselves; should use methods of gaining knowledge that are not oppressive; should continually develop a feminist critical perspective that questions dominant intellectual traditions and can reflect on its own development. Consciously applying these principles in a research study of the relation between changes in consciousness and the changes in the structural situation of individuals raised several methodological issues and dilemmas. These include the impossibility of creating a research process that completely erases the contradictions in the relationship between the researcher and the researched; the difficulties in analysing change as a process; the tension between the necessity of organizing the data and producing an analysis which reveals the totality of women's lives; and problems of validity, particularly those raised when the research process becomes part of the process of change.
713 citations
Authors
Showing all 42777 results
Name | H-index | Papers | Citations |
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Yi Chen | 217 | 4342 | 293080 |
Fred H. Gage | 216 | 967 | 185732 |
Kari Stefansson | 206 | 794 | 174819 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Ruedi Aebersold | 182 | 879 | 141881 |
Jie Zhang | 178 | 4857 | 221720 |
Feng Zhang | 172 | 1278 | 181865 |
Martin G. Larson | 171 | 620 | 117708 |
Michael Snyder | 169 | 840 | 130225 |
Unnur Thorsteinsdottir | 167 | 444 | 121009 |
Anders Björklund | 165 | 769 | 84268 |
Carl W. Cotman | 165 | 809 | 105323 |
Dennis R. Burton | 164 | 683 | 90959 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Panos Deloukas | 162 | 410 | 154018 |