Institution
Lund University
Education•Lund, Sweden•
About: Lund University is a education organization based out in Lund, Sweden. It is known for research contribution in the topics: Population & Cancer. The organization has 42345 authors who have published 124676 publications receiving 5016438 citations. The organization is also known as: Lunds Universitet & University of Lund.
Topics: Population, Cancer, Insulin, Breast cancer, Diabetes mellitus
Papers published on a yearly basis
Papers
More filters
1,356 citations
TL;DR: A genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 that encodes a stoichiometrically limiting component of the super-elongation complex that drives secretory-specific immunoglobulin mRNA production and transcriptional regulation in plasma cells is reported.
Abstract: Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood. Here we report a genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 (rs56219066T; odds ratio (OR)=1.25; P=9.6 × 10(-10)). This gene encodes a stoichiometrically limiting component of the super-elongation complex that drives secretory-specific immunoglobulin mRNA production and transcriptional regulation in plasma cells. We find that the MM risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation. Consistent with a hypomorphic effect, we find that the MM risk allele also associates with reduced levels of immunoglobulin A (IgA) and G (IgG) in healthy subjects (P=8.6 × 10(-9) and P=6.4 × 10(-3), respectively) and, potentially, with an increased risk of bacterial meningitis (OR=1.30; P=0.0024).
1,342 citations
TL;DR: It is possible to use microalgae to produce the O(2) required by acclimatized bacteria to biodegrade hazardous pollutants such as polycyclic aromatic hydrocarbons, phenolics, and organic solvents when proper methods for algal selection and cultivation are used.
1,331 citations
TL;DR: This article developed a framework for thinking about the research interview, and suggested eight metaphors that offer reconceptualizations of the interview, drawing upon recent theoretical trends on language, subject, and discourse, and developed a reflexive theoretical framework.
Abstract: In this article I develop a framework for thinking about the research interview, and I critique dominating neopositivist and romantic views on the interview. I suggest eight metaphors that offer reconceptualizations of the interview, drawing upon recent theoretical trends on language, the subject, and discourse, and develop a reflexive theoretical framework. The article provides new ways of dealing with interviews, along with implications for fieldwork interaction with subjects, interpretations of empirical material, and research questions possible or suitable to address based on interviews.
1,327 citations
Karlstad University1, Dresden University of Technology2, Karolinska University Hospital3, Mental Health Services4, Phillips University5, University of Florence6, Karolinska Institutet7, John Radcliffe Hospital8, King's College London9, London School of Economics and Political Science10, Lund University11, Harvard University12, University of Basel13, Norwegian University of Science and Technology14, University of Zurich15, Umeå University16, University of Cambridge17, University of Lausanne18, University of Sassari19, European Monitoring Centre for Drugs and Drug Addiction20, Aalborg University21, Cliniques Universitaires Saint-Luc22, Maastricht University Medical Centre23, Radboud University Nijmegen24, Stockholm School of Economics25
TL;DR: The present report presents much improved cost estimates for the total cost of disorders of the brain in Europe in 2010, covering 19 major groups of disorders, 7 more than previously, of an increased range of age groups and more cost items.
1,325 citations
Authors
Showing all 42777 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Yi Chen | 217 | 4342 | 293080 |
| Fred H. Gage | 216 | 967 | 185732 |
| Kari Stefansson | 206 | 794 | 174819 |
| Mark I. McCarthy | 200 | 1028 | 187898 |
| Ruedi Aebersold | 182 | 879 | 141881 |
| Jie Zhang | 178 | 4857 | 221720 |
| Feng Zhang | 172 | 1278 | 181865 |
| Martin G. Larson | 171 | 620 | 117708 |
| Michael Snyder | 169 | 840 | 130225 |
| Unnur Thorsteinsdottir | 167 | 444 | 121009 |
| Anders Björklund | 165 | 769 | 84268 |
| Carl W. Cotman | 165 | 809 | 105323 |
| Dennis R. Burton | 164 | 683 | 90959 |
| Jaakko Kaprio | 163 | 1532 | 126320 |
| Panos Deloukas | 162 | 410 | 154018 |