Medical Research Council

About: Medical Research Council is a government organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Malaria. The organization has 16430 authors who have published 19150 publications receiving 1475494 citations.

Identification of the cerebral loci processing human swallowing with H2(15)O PET activation.

Abstract: Identification of the cerebral loci processing human swallowing with H2 15O PET activation. Lesional and electrophysiological data implicate a role for the cerebral cortex in the initiation and mod...

Structure of polyglycine II.

Abstract: During the 1950s Crick made crucial contributions not only to the study of DNA and the genetic code, but to X-ray structure analysis of important biological molecules. In this paper, Crick and Alexander Rich, a visiting physical chemist in the Cavendish laboratory who had studied the structure of RNA with James Watson at the California Institute of Technology, applied X-ray diffraction theory to deduce the three-dimensional structure of polyglycene II, a synthetic polymer consisting of an array of polypeptide chains made up solely of the amino acid glycene.

Growth and activities of sulphate-reducing bacteria in gut contents of healthy subjects and patients with ulcerative colitis

Abstract: During fermentation in the human large intestine, terminal oxidative processes may involve the activities of dissimilatory sulphate-reducing bacteria (SRB). Approximately 50% of healthy individuals harbour significant populations of SRB in faeces. In mixed culture, growth of SRB in vitro was modulated by sulphate availability, with sulphated polysaccharides such as mucin, chondroitin sulphate and carrageenan causing increased growth rates and sulphide production when compared with starch, pectin and arabino-galactan. Rates of H2S production were higher among SRB isolated from patients with ulccrative colitis in contrast to those present in healthy volunteers. The majority (up to 92%) of SRB in faecal samples belonged to the genus Desulfovibrio. In vitro studies demonstrated that compared to isolates from healthy subjects. Desulfovibrio desulfuricans from colitic individuals were better able to adapt to high dilution rates, which may be associated with the disease. These findings indicate that the metabolic capabilities of SRB isolated from the human large intestine are not uniform and may respond to the type of substrate available in the gut as well as the rate of passage of digesta.