Mines ParisTech

About: Mines ParisTech is a education organization based out in Paris, France. It is known for research contribution in the topics: Finite element method & Microstructure. The organization has 6564 authors who have published 11676 publications receiving 359898 citations. The organization is also known as: École nationale supérieure des mines de Paris & École des mines de Paris.

Orientation splitting of cube-oriented face-centred cubic crystals in plane strain compression

Abstract: Orientation splitting of cube-oriented f.c.c. crystals during plane strain compression is analysed by assuming the development of deformation bands in the direction of extension. The bands are considered to undergo the macroscopic normal strain components but are allowed to shear in opposite senses along the elongation direction (local relaxed constraints model). It is shown that this local deformation banding leads, for both the (001)[010] and (001)[110] orientations, to large lattice rotations of opposite sign about the transverse axis and hence the formation of transition bands. Analytical expressions are derived for the lattice rotations up to true strains of about unity. Experimental plane strain compression tests on (001)[010] and (001)[110] aluminium single crystals confirm the predicted behaviour and indicate the spatial distribution of the bands and their slip systems. It is shown that the bands in the (001)[110] orientation are characterized by double coplanar slip while those in the cube crystals behave according to a single-slip model.

Instantiating and detecting design patterns: putting bits and pieces together

Abstract: Design patterns ease the designing, understanding, and re-engineering of software. Achieving a well-designed piece of software requires a deep understanding and a good practice of design patterns. Understanding existing software relies on the ability to identify architectural forms resulting from the implementation of design patterns. Maintaining software involves spotting places that can be improved by using better design decisions, like those advocated by design patterns. Nevertheless, there is a lack of tools automatizing the use of design patterns to achieve well-designed pieces of software, to identify recurrent architectural forms, and to maintain software. We present a set of tools and techniques to help OO software practitioners design, understand, and re-engineer a piece of software using design-patterns. A first prototype tool, PATTERNS-BOX, provides assistance in designing the architecture of a new piece of software, while a second prototype tool, PTIDEJ, identifies design patterns used in an existing one. These tools, in combination, support maintenance by highlighting defects in an existing design, and by suggesting and applying corrections based on widely-accepted design pattern solutions.

Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

Abstract: During fertilization, an egg cell and a sperm cell combine to make a cell called a zygote that then divides many times to form an embryo. Many of the characteristics of the embryo are determined by the genes it inherits from its parents. However, not all of these genes should be “expressed” to produce their products all of the time. One way of controlling gene expression is to add a chemical group called a methyl tag to the DNA near the gene, or to one of the histone proteins that DNA wraps around. Soon after fertilization, a process called reprogramming occurs that begins with the rearrangement of most of the methyl tags a zygote inherited from the egg and sperm cells. This dynamic process is thought to help to activate a new pattern of gene expression. Reprogramming is assisted by “maternal factors” that are inherited from the egg cell. KDM1A is a histone demethylase enzyme that can remove specific methyl tags from certain histone proteins, but how this affects the zygote is not well understood. Now, Ancelin et al. (and independently Wasson et al.) have investigated the role that KDM1A plays in mouse development. Ancelin et al. genetically engineered mouse eggs to lack KDM1A and used them to create zygotes, which die before or shortly after they have divided for the first time. The zygotes display severe reprogramming faults (because methyl tags accumulate at particular histones) and improper gene expression patterns, preventing a correct maternal-to-zygotic transition. Further experiments then showed that KDM1A also regulates the expression level of specific mobile elements, which indicates its importance in maintaining the integrity of the genome. These findings provide important insights on the crucial role of KDM1A in establishing the proper expression patterns in zygotes that are required for early mouse development. These findings might help us to understand how KDM1A enzymes, and histone demethylases more generally, perform similar roles in human development and diseases such as cancer.