Institution
Mines ParisTech
Education•Paris, France•
About: Mines ParisTech is a education organization based out in Paris, France. It is known for research contribution in the topics: Finite element method & Microstructure. The organization has 6564 authors who have published 11676 publications receiving 359898 citations. The organization is also known as: École nationale supérieure des mines de Paris & École des mines de Paris.
Papers published on a yearly basis
Papers
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TL;DR: Among all the chlorot toxin-based strategies, the most promising one to enhance patient mean survival time appears to be the use of chlorotoxin as a targeting agent for the delivery of anti-tumor agents.
Abstract: Chlorotoxin is a small 36 amino-acid peptide identified from the venom of the scorpion Leiurus quinquestriatus. Initially, chlorotoxin was used as a pharmacological tool to characterize chloride channels. While studying glioma-specific chloride currents, it was soon discovered that chlorotoxin possesses targeting properties towards cancer cells including glioma, melanoma, small cell lung carcinoma, neuroblastoma and medulloblastoma. The investigation of the mechanism of action of chlorotoxin has been challenging because its cell surface receptor target remains under questioning since two other receptors have been claimed besides chloride channels. Efforts on chlorotoxin-based applications focused on producing analogues helpful for glioma diagnosis, imaging and treatment. These efforts are welcome since gliomas are very aggressive brain cancers, close to impossible to cure with the current therapeutic arsenal. Among all the chlorotoxin-based strategies, the most promising one to enhance patient mean survival time appears to be the use of chlorotoxin as a targeting agent for the delivery of anti-tumor agents. Finally, the discovery of chlorotoxin has led to the screening of other scorpion venoms to identify chlorotoxin-like peptides. So far several new candidates have been identified. Only detailed research and clinical investigations will tell us if they share the same anti-tumor potential as chlorotoxin.
128 citations
TL;DR: This article presents an improvement of Brah and Hunsucker's branch and bound algorithm for solving a k-stage hybrid flowshop scheduling problem and proves that the value of their lower bound may decrease along a path of the search tree.
128 citations
TL;DR: In this article, a two-point calibration procedure was proposed for continuous glucose monitoring, where one point calibration was performed before each meal, and the other was performed after each meal.
128 citations
TL;DR: It is proposed that monoallelic expression of such genes contributes to the fine-tuning of the developmental regulatory pathways they control, and, in the context of a mutation, RME can predispose to loss of function in a proportion of cells and thus contribute to disease.
127 citations
TL;DR: The resin was chemically modified through the reaction with tetraethylenepentamine (TEPA) to produce amine bearing chitosan to show higher affinity towards the uptake of UO2(2+) ions from aqueous medium and desorption yield as high as 98% was obtained.
127 citations
Authors
Showing all 6591 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Francis Bach | 110 | 484 | 54944 |
| Olivier Delattre | 103 | 490 | 39258 |
| Richard M. Murray | 97 | 711 | 69016 |
| Bruno Latour | 96 | 364 | 94864 |
| George G. Malliaras | 94 | 382 | 28533 |
| George S. Wilson | 88 | 716 | 33034 |
| Zhong-Ping Jiang | 81 | 597 | 24279 |
| F. Liu | 80 | 428 | 23869 |
| Kazu Suenaga | 75 | 329 | 26287 |
| Carlo Adamo | 75 | 444 | 36092 |
| Edith Heard | 75 | 196 | 23899 |
| Enrico Zio | 73 | 1127 | 23809 |
| John J. Jonas | 70 | 379 | 21544 |
| Bernard Asselain | 69 | 409 | 23648 |
| Eric Guibal | 69 | 294 | 16397 |