Mines ParisTech

About: Mines ParisTech is a education organization based out in Paris, France. It is known for research contribution in the topics: Finite element method & Microstructure. The organization has 6564 authors who have published 11676 publications receiving 359898 citations. The organization is also known as: École nationale supérieure des mines de Paris & École des mines de Paris.

MACSE: Multiple Alignment of Coding SEquences accounting for frameshifts and stop codons.

Abstract: Until now the most efficient solution to align nucleotide sequences containing open reading frames was to use indirect procedures that align amino acid translation before reporting the inferred gap positions at the codon level. There are two important pitfalls with this approach. Firstly, any premature stop codon impedes using such a strategy. Secondly, each sequence is translated with the same reading frame from beginning to end, so that the presence of a single additional nucleotide leads to both aberrant translation and alignment. We present an algorithm that has the same space and time complexity as the classical Needleman-Wunsch algorithm while accommodating sequencing errors and other biological deviations from the coding frame. The resulting pairwise coding sequence alignment method was extended to a multiple sequence alignment (MSA) algorithm implemented in a program called MACSE (Multiple Alignment of Coding SEquences accounting for frameshifts and stop codons). MACSE is the first automatic solution to align protein-coding gene datasets containing non-functional sequences (pseudogenes) without disrupting the underlying codon structure. It has also proved useful in detecting undocumented frameshifts in public database sequences and in aligning next-generation sequencing reads/contigs against a reference coding sequence. MACSE is distributed as an open-source java file executable with freely available source code and can be used via a web interface at: http://mbb.univ-montp2.fr/macse.

The key to success in innovation part i: the art of interessement

Abstract: We all know of innovations which either made their creators a fortune or which led to their downfall. It is easy to retrospectively explain success as a stroke of genius or failure as a blatant mistake. Easy in retrospect…but what about innovation in the making? How does the innovator navigate the pitfalls which threaten him?

Micromorphic Approach for Gradient Elasticity, Viscoplasticity, and Damage

Abstract: A unifying thermomechanical framework is presented that reconciles several classes of gradient elastoviscoplasticity and damage models proposed in the literature during the last 40 years . It is based on the introduction of the micromorphic counterpart ϕχ of a selected state or internal variable ϕ in a standard constitutive model. In addition to the classical balance of momentum equation, a balance of micromorphic momentum is derived that involves generalized stress tensors. The corresponding additional boundary conditions are also deduced from the procedure. The power of generalized forces is assumed to contribute to the energy balance equation. The free energy density function is then chosen to depend on a relative generalized strain, typically ϕ- ϕχ , and the microstrain gradient ∇ ϕχ . When applied to the deformation gradient itself, ϕ≡ F , the method yields the micromorphic theory of Eringen and Mindlin together with its extension to finite deformation elastoviscoplasticity by Forest and Sievert. If...