Institution
National Research University – Higher School of Economics
Education•Moscow, Russia•
About: National Research University – Higher School of Economics is a education organization based out in Moscow, Russia. It is known for research contribution in the topics: Population & Computer science. The organization has 12873 authors who have published 23376 publications receiving 256396 citations.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this paper, the authors tested the main assumptions of the slippery slope framework in four European countries differing in terms of cultural and economic settings (Austria, Hungary, Romania and Russia) by presenting participants with different scenarios of trust and power.
233 citations
••
TL;DR: Evidence is provided that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less compacted and transcription within them is increased.
Abstract: How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood. Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and repositioning from the nuclear envelope. This increases the chromatin density in a fraction of topologically-associating domains (TADs) enriched in active chromatin and enhances interactions between active and inactive chromatin. Importantly, upon NL disruption the NL-associated TADs become more acetylated at histone H3 and less compact, while background transcription is derepressed. Two-colour FISH confirms that a TAD becomes less compact following its release from the NL. Finally, polymer simulations show that chromatin binding to the NL can per se compact attached TADs. Collectively, our findings demonstrate a dual function of the NL in shaping the 3D genome. Attachment of TADs to the NL makes them more condensed but decreases the overall chromatin density in the nucleus by stretching interphase chromosomes. The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less compacted and transcription within them is increased.
229 citations
••
Clinical Trial Service Unit1, Max Planck Society2, National Research University – Higher School of Economics3, Harvard University4, University of Milan5, University of Leicester6, Leicester General Hospital7, University Hospitals of Leicester NHS Trust8, University of Cambridge9, University of Oxford10
TL;DR: In this paper, the authors estimate the direct and indirect effects of the covid-19 pandemic on mortality in 29 high income countries with reliable and complete age and sex disaggregated mortality data.
Abstract: Objective To estimate the direct and indirect effects of the covid-19 pandemic on mortality in 2020 in 29 high income countries with reliable and complete age and sex disaggregated mortality data. Design Time series study of high income countries. Setting Austria, Belgium, Czech Republic, Denmark, England and Wales, Estonia, Finland, France, Germany, Greece, Hungary, Israel, Italy, Latvia, Lithuania, the Netherlands, New Zealand, Northern Ireland, Norway, Poland, Portugal, Scotland, Slovakia, Slovenia, South Korea, Spain, Sweden, Switzerland, and United States. Participants Mortality data from the Short-term Mortality Fluctuations data series of the Human Mortality Database for 2016-20, harmonised and disaggregated by age and sex. Interventions Covid-19 pandemic and associated policy measures. Main outcome measures Weekly excess deaths (observed deaths versus expected deaths predicted by model) in 2020, by sex and age (0-14, 15-64, 65-74, 75-84, and ≥85 years), estimated using an over-dispersed Poisson regression model that accounts for temporal trends and seasonal variability in mortality. Results An estimated 979 000 (95% confidence interval 954 000 to 1 001 000) excess deaths occurred in 2020 in the 29 high income countries analysed. All countries had excess deaths in 2020, except New Zealand, Norway, and Denmark. The five countries with the highest absolute number of excess deaths were the US (458 000, 454 000 to 461 000), Italy (89 100, 87 500 to 90 700), England and Wales (85 400, 83 900 to 86 800), Spain (84 100, 82 800 to 85 300), and Poland (60 100, 58 800 to 61 300). New Zealand had lower overall mortality than expected (−2500, −2900 to −2100). In many countries, the estimated number of excess deaths substantially exceeded the number of reported deaths from covid-19. The highest excess death rates (per 100 000) in men were in Lithuania (285, 259 to 311), Poland (191, 184 to 197), Spain (179, 174 to 184), Hungary (174, 161 to 188), and Italy (168, 163 to 173); the highest rates in women were in Lithuania (210, 185 to 234), Spain (180, 175 to 185), Hungary (169, 156 to 182), Slovenia (158, 132 to 184), and Belgium (151, 141 to 162). Little evidence was found of subsequent compensatory reductions following excess mortality. Conclusion Approximately one million excess deaths occurred in 2020 in these 29 high income countries. Age standardised excess death rates were higher in men than women in almost all countries. Excess deaths substantially exceeded reported deaths from covid-19 in many countries, indicating that determining the full impact of the pandemic on mortality requires assessment of excess deaths. Many countries had lower deaths than expected in children
228 citations
University of Queensland1, Queensland University of Technology2, Victoria University of Wellington3, University of Melbourne4, University of Warsaw5, Interdisciplinary Center Herzliya6, University of Iceland7, Federal University of Paraíba8, University of Surrey9, University of Gothenburg10, Simón Bolívar University11, Universidad de Sonora12, Complutense University of Madrid13, University of Toulouse14, Otto-von-Guericke University Magdeburg15, Nagoya University of Commerce & Business16, University of Zurich17, University of Groningen18, Pontifical Catholic University of Chile19, National Research University – Higher School of Economics20, University of Oslo21, University of Pretoria22, University of Ghana23, University of Exeter24, University of La Frontera25, California State University San Marcos26
TL;DR: This paper investigated whether potential co-benefits of addressing climate change could motivate pro-environmental behavior around the world for both those convinced and unconvinced that climate change is real.
Abstract: Personal and political action on climate change is traditionally thought to be motivated by people accepting its reality and importance. However, convincing the public that climate change is real faces powerful ideological obstacles1, 2, 3, 4, and climate change is slipping in public importance in many countries5, 6. Here we investigate a different approach, identifying whether potential co-benefits of addressing climate change7 could motivate pro-environmental behaviour around the world for both those convinced and unconvinced that climate change is real. We describe an integrated framework for assessing beliefs about co-benefits8, distinguishing social conditions (for example, economic development, reduced pollution or disease) and community character (for example, benevolence, competence). Data from all inhabited continents (24 countries; 6,196 participants) showed that two co-benefit types, Development (economic and scientific advancement) and Benevolence (a more moral and caring community), motivated public, private and financial actions to address climate change to a similar degree as believing climate change is important. Critically, relationships were similar for both convinced and unconvinced participants, showing that co-benefits can motivate action across ideological divides. These relationships were also independent of perceived climate change importance, and could not be explained by political ideology, age, or gender. Communicating co-benefits could motivate action on climate change where traditional approaches have stalled.
226 citations
••
TL;DR: The authors analyzed relations between indices of investors' legal rights and national cultural profiles and found that these indices correlate with cultural priorities that are consistent with societal acceptance of litigation, which may be related to a heritage of British rule.
Abstract: This article advances a new framework for investigating a simple yet fundamental question: In what ways does the law on the books reflect cultural values? We analyze relations between indices of investors' legal rights - as coded by La Porta et al. (LLSV) - and national cultural profiles. These indices correlate with cultural priorities that are consistent with societal acceptance of litigation. Indices of formalism in civil procedure exhibit similar correlations. Such societal stance may be related to a heritage of British rule. Grouping countries according to legal families - the cornerstone of LLSV's legal approach - provides only a partial depiction of the universe of corporate governance regimes. Our findings cast doubt on the alleged general supremacy of statutes in common law countries. These findings have implications for understanding diversity and convergence in corporate governance systems and for a systematic analysis of the interface between law and social institutions.
225 citations
Authors
Showing all 13307 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rasmus Nielsen | 135 | 556 | 84898 |
Matthew Jones | 125 | 1161 | 96909 |
Fedor Ratnikov | 123 | 1104 | 67091 |
Kenneth J. Arrow | 113 | 411 | 111221 |
Wil M. P. van der Aalst | 108 | 725 | 42429 |
Peter Schmidt | 105 | 638 | 61822 |
Roel Aaij | 98 | 1071 | 44234 |
John W. Berry | 97 | 351 | 52470 |
Federico Alessio | 96 | 1054 | 42300 |
Denis Derkach | 96 | 1184 | 45772 |
Marco Adinolfi | 95 | 831 | 40777 |
Michael Alexander | 95 | 881 | 38749 |
Alexey Boldyrev | 94 | 439 | 32000 |
Shalom H. Schwartz | 94 | 220 | 67609 |
Richard Blundell | 93 | 487 | 61730 |