Institution
Pusan National University
Education•Busan, South Korea•
About: Pusan National University is a education organization based out in Busan, South Korea. It is known for research contribution in the topics: Catalysis & Population. The organization has 24124 authors who have published 45054 publications receiving 819356 citations. The organization is also known as: Busan National University & Pusan University.
Topics: Catalysis, Population, Thin film, Medicine, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: It is shown that environmental stress promotes TEAD cytoplasmic translocation via p38 MAPK in a Hippo-independent manner and stress-induced TEAD inhibition predominates YAP-activating signals and selectively suppresses YAP's cancer cell growth.
Abstract: The Hippo pathway controls organ size and tissue homeostasis, with deregulation leading to cancer. The core Hippo components in mammals are composed of the upstream serine/threonine kinases Mst1/2, MAPK4Ks and Lats1/2. Inactivation of these upstream kinases leads to dephosphorylation, stabilization, nuclear translocation and thus activation of the major functional transducers of the Hippo pathway, YAP and its paralogue TAZ. YAP/TAZ are transcription co-activators that regulate gene expression primarily through interaction with the TEA domain DNA-binding family of transcription factors (TEAD). The current paradigm for regulation of this pathway centres on phosphorylation-dependent nucleocytoplasmic shuttling of YAP/TAZ through a complex network of upstream components. However, unlike other transcription factors, such as SMAD, NF-κB, NFAT and STAT, the regulation of TEAD nucleocytoplasmic shuttling has been largely overlooked. In the present study, we show that environmental stress promotes TEAD cytoplasmic translocation via p38 MAPK in a Hippo-independent manner. Importantly, stress-induced TEAD inhibition predominates YAP-activating signals and selectively suppresses YAP-driven cancer cell growth. Our data reveal a mechanism governing TEAD nucleocytoplasmic shuttling and show that TEAD localization is a critical determinant of Hippo signalling output.
139 citations
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Seoul National University1, Korea University2, Sacred Heart Hospital3, Gachon University4, Yonsei University5, Chonnam National University6, Pusan National University7, Hallym University8, Keimyung University9, Inje University10, Ewha Womans University11, Catholic University of Korea12, Sungkyunkwan University13
TL;DR: EES were noninferior to SES in inhibition of LL after stenting, which was corroborated by similar rates of clinical outcomes.
139 citations
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TL;DR: In this paper, the epoxy-copper-ITO (ECI) multilayer electrode was proposed for wearable and transparent force touch sensor array, which is multiplexed by Si nanomembrane p-i-n junction-type (PIN) diodes.
Abstract: Transparent electrodes have been widely used for various electronics and optoelectronics, including flexible ones. Many nanomaterial-based electrodes, in particular 1D and 2D nanomaterials, have been proposed as next-generation transparent and flexible electrodes. However, their transparency, conductivity, large-area uniformity, and sometimes cost are not yet sufficient to replace indium tin oxide (ITO). Furthermore, the conventional ITO is quite rigid and susceptible to mechanical fractures under deformations (e.g., bending, folding). In this study, the authors report new advances in the design, fabrication, and integration of wearable and transparent force touch (touch and pressure) sensors by exploiting the previous efforts in stretchable electronics as well as novel ideas in the transparent and flexible electrode. The optical and mechanical experiment, along with simulation results, exhibit the excellent transparency, conductivity, uniformity, and flexibility of the proposed epoxy-copper-ITO (ECI) multilayer electrode. By using this multi-layered ECI electrode, the authors present a wearable and transparent force touch sensor array, which is multiplexed by Si nanomembrane p-i-n junction-type (PIN) diodes and integrated on the skin-mounted quantum dot light-emitting diodes. This novel integrated system is successfully applied as a wearable human–machine interface (HMI) to control a drone wirelessly. These advances in novel material structures and system-level integration strategies create new opportunities in wearable smart displays.
139 citations
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TL;DR: In this paper, the effect of tetra-n-butyl ammonium bromide (TBAB) additive on separation and/or collection of CO2 from CO2/H2 (40:60) gas mixture via hydrate crystallization was investigated.
139 citations
Authors
Showing all 24296 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
Taeghwan Hyeon | 139 | 563 | 75814 |
George C. Schatz | 137 | 1155 | 94910 |
Darwin J. Prockop | 128 | 576 | 87066 |
Mark A. Ratner | 127 | 968 | 68132 |
Csaba Szabó | 123 | 958 | 61791 |
David E. McClelland | 107 | 602 | 72881 |
Yong Sik Ok | 102 | 854 | 41532 |
C. M. Mow-Lowry | 101 | 378 | 66659 |
I. K. Yoo | 101 | 437 | 32681 |
Haijun Yang | 100 | 403 | 35114 |
Buddy D. Ratner | 99 | 501 | 35660 |
Dong Jo Kim | 98 | 497 | 36272 |
Shuzhi Sam Ge | 97 | 883 | 40865 |
B. J. J. Slagmolen | 96 | 349 | 62356 |