Universidade de Pernambuco

About: Universidade de Pernambuco is a education organization based out in Recife, Brazil. It is known for research contribution in the topics: Population & Medicine. The organization has 6147 authors who have published 6948 publications receiving 73648 citations.

Production of β-Lactamase Inhibitors by Streptomyces Species.

Abstract: β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of resistance against β-lactam antibiotics. The Streptomyces genus is known for being an exceptional natural source of antimicrobials and β-lactamase inhibitors such as clavulanic acid, which is largely applied in clinical practice. To protect against the increasing prevalence of multidrug-resistant bacterial strains, new antibiotics and β-lactamase inhibitors need to be discovered and developed. This review will cover an update about the main β-lactamase inhibitors producers belonging to the Streptomyces genus; advanced methods, such as genetic and metabolic engineering, to enhance inhibitor production compared with wild-type strains; and fermentation and purification processes. Moreover, clinical practice and commercial issues are discussed. The commitment of companies and governments to develop innovative strategies and methods to improve the access to new, efficient, and potentially cost-effective microbial products to combat the antimicrobial resistance is also highlighted.

Prevalence of overweight and obesity and associated factors among public high school students in Pernambuco State, Brazil

Abstract: This study aims to analyze the association between demographic, socioeconomic, school-related, and behavioral factors and overweight and obesity in adolescents. The sample included 4,210 public high school students (14-19 years old) in Pernambuco State, Brazil, selected by two-stage cluster sampling. Obesity and overweight were assessed using anthropometric measurements, and the Global School-Based Health Survey was used to collect personal and behavioral data. The cutoff points for defining overweight and obesity were those recommended by the International Obesity Task Force. Prevalence rates for overweight and obesity were 11.5% (95%CI: 10.7-12.8) and 2.4% (95%CI: 1.9-2.9), respectively. Overweight and obesity were more common in males who reported residing in urban areas and were not enrolled in physical education classes. Watching television 3+ hours/day was associated with obesity in females. Reducing TV time and encouraging enrollment in physical education could be effective measures to counteract the growing obesity trends.

A Modulation Technique to Reduce Switching Losses in Matrix Converters

Abstract: This paper presents a modulation technique based on the generalized pulsewidth-modulation strategy for matrix converters. The proposed technique uses a discontinuous modulation to clamp each output leg of the converter during 120deg of the output voltage period, achieving a reduced number of switchings compared with the traditional modulation techniques. Aside from that, the major attraction of the proposed technique is an additional algorithm that lags the clamping of each output leg of the converter to synchronize it with the peak of the corresponding output current (load current), avoiding high switching losses (switching at high currents). Therefore, this technique reduces the number of switchings as well as guarantees only medium and low current switchings. Simulation and experimental results show the efficiency of the proposed technique.

Cuidado, integralidade e atenção primária: articulação essencial para refletir sobre o setor saúde no Brasil

Abstract: RESUMO Este artigo descreve os elementos teorico-conceituais sobre cuidado, integralidade e Atencao Primaria a Saude, articulando-os e ressaltando a essencialidade destas ideias na estruturacao do sistema de saude no Brasil. Optou-se pelo formato ensaistico segundo os argumentos de Meneghetti e Adorno. Foram apresentados os conceitos de cuidado, integralidade e atencao primaria, assim como algumas criticas de ordem teorico-pratica. Foi demonstrada a existencia de um fio condutor que os une, tornando-os um eixo estrutural do Sistema Unico de Saude, assim como os principais limites e possibilidades dessa articulacao. Por fim, lancou-se uma brevissima sugestao sobre o tema em tempos de crise economico-politica.