Universidade de Pernambuco

About: Universidade de Pernambuco is a education organization based out in Recife, Brazil. It is known for research contribution in the topics: Population & Medicine. The organization has 6147 authors who have published 6948 publications receiving 73648 citations.

Prevalência de pressão arterial elevada em crianças e adolescentes: revisão sistemática

Abstract: OBJETIVOS: identificar as prevalencias de pressao arterial elevada em criancas e adolescentes em estudos publicados nos ultimos 30 anos. METODOS: foi realizada uma busca nas seguintesbases de dados: Medline/PubMed, Lilacs, Web ofScience, Embase e Scielo entre os anos de 1980 e 2009. Foram incluidos estudos originais de prevalencia de pressao arterial elevada ou hipertensao com tamanho amostral superior a 500sujeitos. RESULTADOS: a prevalencia de pressao arterial elevada em criancas e adolescentes de 4 a 20 anos variou de 0,46% a 20,6%. As menores prevalencias de pressao arterial elevada foram detectadas nos estudos em que a maior parte da amostra foi composta por criancas de 4 a 7 anos. Os protocolos mais utilizados na avaliacao da pressao arterial foram o da Task Force e o do National High Blood Pressure Education Program. Ao todo 52,4% dos estudos utilizaram o metodo auscultatorio para verificar a medida de pressao arterial e 47,6%, o metodo oscilometrico. CONCLUSOES: apesar da grande discrepância dos valores de prevalencia encontrados, ressalta-se ocrescimento da prevalencia de pressao arterial elevada na populacao de criancas e adolescentes de diversas partes do mundo.

Further structural characterization of the Echinococcus granulosus laminated layer carbohydrates: The blood-antigen P1-motif gives rise to branches at different points of the O-glycan chains

Abstract: The glycobiology of the cestodes, a class of parasitic flatworms, is still largely unexplored. An important cestode species is Echinococcus granulosus, the tissue-dwelling larval stage of which causes hydatid disease. The E. granulosus larva is protected from the host by a massive mucin-based extracellular matrix termed laminated layer (LL). We previously reported ( Diaz et al. 2009. Biochemistry 48:11678-11691) the molecular structure of the most abundant LL O-glycans, comprising up to six monosaccharide residues. These are based on Cores 1 and 2, in cases elongated by a chain of Galpβ1-3 residues, which can be capped by Galpα1-4. In addition, the Core 2 GlcNAcp residue can be decorated with the Galpα1-4Galpβ1-4 disaccharide. Larger glycans also detected contained additional HexNAc residues that could not be explained by the structural repertoire described above. In this work, we elucidate, by mass spectrometry (MS) and nuclear magnetic resonance (NMR), six additional glycans from the E. granulosus LL between six and eight residues in size. Their structures are related to those already described but in cases bear GlcNAcpβ1-6 or Galpα1-4Galpβ1-4GlcNAcpβ1-6 as ramifications on the core Galpβ1-3 residue. We also obtained evidence that noncore Galpβ1-3 residues can be similarly ramified. Thus, the new motif together with the previous information may explain all the glycan compositions detected in the LL by MS. In addition, we show that the anti-Echinococcus monoclonal antibody E492 (Parasite Immunol 21:141, 1999) recognizes Galpα1-4Galpβ1-4GlcNAcp (the blood P(1)-antigen motif). This explains the antibody's reactivity with a range of Echinococcus tissues, as the P(1)-motif is also carried on non-LL N-glycans and glycolipids from this genus.

Effects of demineralized bone matrix and a 'Ricinus communis' polymer on bone regeneration: a histological study in rabbit calvaria.

Abstract: The aim of the present study was to histologically analyze the effects of bovine and human demineralized bone matrix and a Ricinus communis polymer on the bone regeneration process. Two surgical bone defects were created in rabbit calvaria, one on the right and the other on the left side of the parietal suture. Eighteen rabbits were divided into three groups. In Group I, the experimental defect was treated with bovine demineralized bone matrix, Group II with human demineralized bone matrix, and in Group III, the experimental cavity was treated with polyurethane resin derived from Ricinus communis oil. The control defects were filled with the animals' own blood. The animals were sacrificed after 7 and 15 weeks. Histological analysis revealed that in all groups (control and experimental), bone regeneration increased with time. The least time required for bone regeneration was noted in the control group, with a substantial decrease in the thickness of the defect. All materials proved to be biologically compatible, but polyurethane resorbed more slowly and demonstrated considerably better results than the demineralized bone matrices. (J Oral Sci 51, 451-456, 2009)

High-Intensity Interval Training in Heart Transplant Recipients: A Systematic Review with Meta-Analysis.

Abstract: Heart transplantation (HTx) is considered an efficient and gold-standard procedure for patients with end-stage heart failure. After surgery, patients have lower aerobic power (VO2max) and compensatory hemodynamic responses. The aim of the present study was to assess through a systematic review with meta-analysis whether high-intensity interval training (HIIT) can provide benefits for those parameters. This is a systematic review with meta-analysis, which searched the databases and data portals PubMed, Web of Science, Scopus, Science Direct and Wiley until December 2016 (pairs). The following terms and descriptors were used: "heart recipient" OR "heart transplant recipient" OR "heart transplant" OR "cardiac transplant" OR "heart graft". Descriptors via DeCS and Mesh were: "heart transplantation'' OR "cardiac transplantation". The words used in combination (AND) were: "exercise training" OR "interval training" OR "high intensity interval training" OR "high intensity training" OR "anaerobic training" OR "intermittent training" OR "sprint training". The initial search identified 1064 studies. Then, only those studies assessing the influence of HIIT on the post-HTx period were added, resulting in three studies analyzed. The significance level adopted was 0.05. Heart transplant recipients showed significant improvement in VO2peak, heart rate and peak blood pressure in 8 to 12 weeks of intervention.

Malocclusion and treatment need in children and adolescents with sickle cell disease.

Abstract: Objective: To assess the prevalence of malocclusion and treatment need in children and adolescents with sickle cell disease (SCD). Materials and Methods: In this cross-sectional study, the sample size comprised 35 five-year-old children and 36 adolescents of both sexes, aged between 12 to 18 years, with SCD. Dental occlusion was assessed using two indexes: the Malocclusion Index (World Health Organization) and the Dental Aesthetic Index (DAI). Results: The prevalence of malocclusion in the preschool children was 62.9%. The main malocclusions observed in this age group were Class II (37.1%), increased overjet (28.6%), reduced overbite (28.6%), and open bite (17.1%). In the 12- to 18-year-old subjects, the prevalence of malocclusion was 100%, and the most prevalent types of malocclusion were maxillary overjet (63.9%) and maxillary misalignment (58.3%). It is noteworthy that the majority of adolescents (80.6%) had very severe or disabling malocclusions. Conclusion: The results revealed a high preval...