Institution
University of Lincoln
Education•Lincoln, Lincolnshire, United Kingdom•
About: University of Lincoln is a education organization based out in Lincoln, Lincolnshire, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 2341 authors who have published 7025 publications receiving 124797 citations.
Papers published on a yearly basis
Papers
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TL;DR: The substantial temporal gap between the origin of postcranial features associated with terrestriality, such as limbs with functional elbow/knee and wrist/ankle joints capable of weight-bearing, and the onset of divergence in jaw biomechanics provides a compelling example of "functional modularity" during a major adaptive radiation.
Abstract: The origin of digit-bearing tetrapods in the Middle to Late Devonian (ca 393–360 Mya) and their subsequent invasion of land represent a classic case of a major evolutionary radiation driven by new ecological opportunities In this and other examples, exploration of new eco-space is hypothesized to correlate with functional innovation and adaptive divergence of phenotypes Simultaneous changes in all morphofunctional systems are rare in major evolutionary transitions and may be non-existent Here, we focus on the mandibles of early tetrapods and their kin as a model system to test whether shifts in functional innovation were coeval with some major events in tetrapod history To this end, we quantified mechanical variation in the mandibles of tetrapodomorphs ranging in age from Early Devonian to earliest Permian Biomechanical disparity is stable from the Devonian to the Early Pennsylvanian, even though the origin of weight-bearing, digited limbs, and the initial phases of the colonization of land occurred during this interval An appreciable increase in functional variation is detected in the latest Pennsylvanian and earliest Permian, when stem and crown amniotes began to explore new regions of mechanical morphospace, a pattern partly attributable to the origin of herbivory We find no difference in the rate of functional change between tetrapodomorph “fish” and early digited tetrapods, although two independent shifts are detected among Devonian stem tetrapods more crownward than Acanthostega Instead, the most profound shifts in evolutionary rate are nested well within the tetrapod crown and are associated with amniotes (particularly diadectomorphs and some synapsids) The substantial temporal gap between the origin of postcranial features associated with terrestriality, such as limbs with functional elbow/knee and wrist/ankle joints capable of weight-bearing, and the onset of divergence in jaw biomechanics provides a compelling example of “functional modularity” during a major adaptive radiation
51 citations
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TL;DR: CriticalSorb is the principle component of CriticalSorb that has shown an enhancement in permeability of medium sized biological drugs across epithelia and suggests that its mechanism of action arises primarily from effects on the cell membrane and consequent impacts on thecell cytoskeleton in terms of actin organisation and tight junction opening.
Abstract: Purpose
CriticalSorb™, with the principal component Solutol® HS15, is a novel mucosal drug delivery system demonstrated to improve the bioavailability of selected biotherapeutics. The intention of this study is to elucidate mechanism(s) responsible for the enhancement of trans-mucosal absorption of biological drugs by Solutol® HS15.
51 citations
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TL;DR: Findings demonstrate the children's and young people's understanding of the impact of poverty and social exclusion on their family life and their everyday experiences.
Abstract: This paper reports on the experiences and views of children and young people of single-parent families, as findings from a European Union-funded research project undertaken in England, Greece and Cyprus. The objectives of the research project were to investigate how children and young people of single-parent families understand and experience their worlds as members of these families: whether and to what extent they experience poverty and social exclusion and how they cope with the challenges that this confronts them with. Methodology was replicated in each of the countries; however, this paper draws on the English experiences. Semistructured interviews (40) and focus groups (four) were undertaken with children of single parents. In addition, focus groups were undertaken with children of two-parent families (four), focus groups with single parents, focus groups with two-parent families (four) and individual interviews with key professionals. Detailed discussion guides were followed, with open-ended questions to allow participants to express their feelings and ideas in their own words. The research sample included children from single-parent and two-parent families, aged 6 years to 16 years, balanced in terms of age, gender and geographical location. Findings demonstrate the children's and young people's understanding of the impact of poverty and social exclusion on their family life and their everyday experiences. The positive benefits of being in a single-parent family are highlighted, with 'time poverty' raised as a significant issue. Children and young people are aware of their poverty and how it influences exclusion from friendships, play, leisure and community activities. Policy needs to take account of the systematic reality of children's experiences; alliances with adults that support meaningful involvement and participation by children and young people will make a significant contribution to this.
51 citations
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TL;DR: To the knowledge, this is the first model of OSS evolution that includes the complexity of software modules as a limiting factor in productivity, the fitness of the software to its requirements, and the motivation of developers.
Abstract: We present an agent-based simulation model developed to study how size, complexity and effort relate to each other in the development of open source software (OSS). In the model, many developer agents generate, extend, and re-factor code modules independently and in parallel. This accords with empirical observations of OSS development. To our knowledge, this is the first model of OSS evolution that includes the complexity of software modules as a limiting factor in productivity, the fitness of the software to its requirements, and the motivation of developers.
Validation of the model was done by comparing the simulated results against four measures of software evolution (system size, proportion of highly complex modules, level of complexity control work, and distribution of changes) for four large OSS systems. The simulated results resembled the observed data, except for system size: three of the OSS systems showed alternating patterns of super-linear and sub-linear growth, while the simulations produced only super-linear growth. However, the fidelity of the model for the other measures suggests that developer motivation and the limiting effect of complexity on productivity have a significant effect on the development of OSS systems and should be considered in any model of OSS development.
51 citations
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TL;DR: In this paper, urban-rural interdependences are modelled based on wages, cost of living, and interregional migration and commuting and rural-to-urban commuting generates a scenario where the relative level of urban...
Abstract: Urban–rural interdependences are modelled based on wages, cost of living, and interregional migration and commuting. Rural-to-urban commuting generates a scenario where the relative level of urban ...
51 citations
Authors
Showing all 2452 results
Name | H-index | Papers | Citations |
---|---|---|---|
David R. Williams | 178 | 2034 | 138789 |
David Scott | 124 | 1561 | 82554 |
Hugh S. Markus | 118 | 606 | 55614 |
Timothy E. Hewett | 116 | 531 | 49310 |
Wei Zhang | 96 | 1404 | 43392 |
Matthew Hall | 75 | 827 | 24352 |
Matthew C. Walker | 73 | 443 | 16373 |
James F. Meschia | 71 | 401 | 28037 |
Mark G. Macklin | 69 | 268 | 13066 |
John N. Lester | 66 | 349 | 19014 |
Christine J Nicol | 61 | 268 | 10689 |
Lei Shu | 59 | 598 | 13601 |
Frank Tanser | 54 | 231 | 17555 |
Simon Parsons | 54 | 462 | 15069 |
Christopher D. Anderson | 54 | 393 | 10523 |