University of Lincoln

About: University of Lincoln is a education organization based out in Lincoln, Lincolnshire, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 2341 authors who have published 7025 publications receiving 124797 citations.

Social learning by imitation in a reptile (Pogona vitticeps)

Abstract: The ability to learn through imitation is thought to be the basis of cultural transmission and was long con- sidered a distinctive characteristic of humans. There is now evidence that both mammals and birds are capable of imitation. However, nothing is known about these abilities in the third amniotic class—reptiles. Here, we use a bidi- rectional control procedure to show that a reptile species, the bearded dragon (Pogona vitticeps), is capable of social learning that cannot be explained by simple mechanisms such as local enhancement or goal emulation. Subjects in the experimental group opened a trap door to the side that had been demonstrated, while subjects in the ghost control group, who observed the door move without the interven- tion of a conspecific, were unsuccessful. This, together with differences in behaviour between experimental and control groups, provides compelling evidence that reptiles possess cognitive abilities that are comparable to those observed in mammals and birds and suggests that learning by imitation is likely to be based on ancient mechanisms.

Chemical diversity in a metal-organic framework revealed by fluorescence lifetime imaging.

Abstract: The presence and variation of chemical functionality and defects in crystalline materials, such as metal-organic frameworks (MOFs), have tremendous impact on their properties. Finding a means of identifying and characterizing this chemical diversity is an important ongoing challenge. This task is complicated by the characteristic problem of bulk measurements only giving a statistical average over an entire sample, leaving uncharacterized any diversity that might exist between crystallites or even within individual crystals. Here, we show that by using fluorescence imaging and lifetime analysis, both the spatial arrangement of functionalities and the level of defects within a multivariable MOF crystal can be determined for the bulk as well as for the individual constituent crystals. We apply these methods to UiO-67 to study the incorporation of functional groups and their consequences on the structural features. We believe that the potential of the techniques presented here in uncovering chemical diversity in what is generally assumed to be homogeneous systems can provide a new level of understanding of materials properties.

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.

Abstract: The National Institute of Health Research (NIHR) BioResource for Rare Diseases provided funding for sequencing and analysis The study was supported by a British Heart Foundation Special Project Grant and a Medical Research Council (UK) Experimental Challenge Award

The effect of ambient scent on consumers' perception, emotions, and behaviour: A critical review

Abstract: The effect of olfactory stimuli on consumer behaviour has received little attention in marketing and retailing literature compared to other atmospheric cues. Researchers report ambiguous findings and shortcomings of measurement approaches. Based on a critical literature review, a field experiment in a regional shopping mall investigates the effectiveness of ambient scent. Before-and-after surveys of randomly selected shoppers in experimental and control groups were conducted and different experimental designs simulated. Those designs not controlling either extraneous variables or attitudinal differences between the control and experimental group reveal a positive effect on factors operationalising mall perception and consumers' emotions. The design controlling both sources of bias indicates no impact of ambient scent on the dependent variables. None of the behavioural variables were affected in any case. This paper questions prior findings on the effectiveness of ambient scent in a shopping-mall ...

The role of BMP-6, IL-6, and BMP-4 in mesenchymal stem cell-dependent bone development: effects on osteoblastic differentiation induced by parathyroid hormone and vitamin D(3).

Abstract: Human bone marrow-derived mesenchymal stem cells (MSCs) represent an ideal source for cell therapy for inherited and degenerative diseases, bone and cartilage repair, and as target for gene therapy. The role of the combination of human parathyroid hormone (PTH) and vitamin D(3) in bone formation and mineralization has been established in several osteoblast cell culture studies. The aim of the present study was to evaluate the role of this hormonal combination alone and in the presence of bone morphogenetic protein-4 (BMP-4) or-6 (BMP-6) in inducing osteogenic differentiation of human MSC. Human MSC derived from adult normal bone marrow that are positive for CD29, CD44, CD105, and CD166 and negative for CD14, CD34, and CD45, were treated with the PTH and 1,25-dihydroxyvitamin D(3) in the presence and absence of recombinant human BMP-4 or BMP6. PTH and vitamin D(3) induced high levels of expression of two key markers of bone formation: osteocalcin and alkaline phosphatase by MSCs. BMP-6 but not BMP-4 increased osteocalcin expression induced by PTH and vitamin D(3). Both BMPs enhanced calcium formation in MSC cultures and this response was potentiated by PTH and vitamin D(3). The present results revealed a novel potent effect of PTH and vitamin D(3) plus BMPs in inducing bone development by human MSCs. These results may facilitate therapeutic utility of MSCs for bone disease and help clarify mechanisms involved in stem cell-mediated bone development.