Institution
University of Lincoln
Education•Lincoln, Lincolnshire, United Kingdom•
About: University of Lincoln is a education organization based out in Lincoln, Lincolnshire, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 2341 authors who have published 7025 publications receiving 124797 citations.
Papers published on a yearly basis
Papers
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TL;DR: Although acute non‐haemolytic febrile or allergic reactions (ATRs) are a common complication of transfusion and often result in little or no morbidity, prompt recognition and management are essential.
Abstract: Although acute non-haemolytic febrile or allergic reactions (ATRs) are a common complication of transfusion and often result in little or no morbidity, prompt recognition and management are essential. The serious hazards of transfusion haemovigilance organisation (SHOT) receives 30-40 reports of anaphylactic reactions each year. Other serious complications of transfusion, such as acute haemolysis, bacterial contamination, transfusion-related acute lung injury (TRALI) or transfusion-associated circulatory overload (TACO) may present with similar clinical features to ATR. This guideline describes the approach to a patient developing adverse symptoms and signs related to transfusion, including initial recognition, establishing a likely cause, treatment, investigations, planning future transfusion and reporting within the hospital and to haemovigilance organisations. Key recommendations are that adrenaline should be used as first line treatment of anaphylaxis, and that transfusions should only be carried out where patients can be directly observed and where staff are trained in manging complications of transfusion, particularly anaphylaxis. Management of ATRs is not dependent on classification but should be guided by symptoms and signs. Patients who have experienced an anaphylactic reaction should be discussed with an allergist or immunologist, in keeping with UK resuscitation council guidelines.
115 citations
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TL;DR: Switched-off DCs in patients with early breast cancer and decreased IL-12 production may be important factors for progressive tumour growth.
Abstract: Background: Dendritic cells (DCs) play a crucial role in presenting antigens to T lymphocytes and inducing cytotoxic T cells. DCs have been studied in patients with breast cancer to define the factors leading to failure of an effective systemic and locoregional anticancer host response. Methods: Purified DCs were obtained from peripheral blood (PB) and lymph nodes (LNs) of women with operable breast cancer, using immunomagnetic bead selection. The stimulatory capacity of DCs in the allogeneic mixed leukocyte reaction (MLR) and autologous T cell proliferation test (purified protein derivative (PPD) as stimulator), the expression of surface markers on DCs and the production of cytokines in vitro by DCs from patients with operable breast cancer and from healthy donors (controls) were studied. Results: 70–75% purified DCs were isolated from PB and LNs. PBDCs and LNDCs from patients with operable breast cancer demonstrated a reduced capacity to stimulate in an MLR, compared with PBDCs from normal donors (p<0.01). Autologous T cell proliferation in patients had a decreased ability to respond to PPD, when compared with controls (p<0.01). However, T cells from patients responded as well as control T lymphocytes in the presence of control DCs. PBDCs and LNDCs from patients expressed low levels of HLA-DR and CD86, and induced decreased interleukin-12 (IL-12) secretion in vitro, compared with DCs from normal donors (p<0.01). Conclusion: These data suggest a defective DC function in patients with operable breast cancer. Switched-off DCs in patients with early breast cancer and decreased IL-12 production may be important factors for progressive tumour growth.
115 citations
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TL;DR: In this paper, a scientometric analysis and critical review of the use of Palladium-based alloy materials as cathodes for the reduction of oxygen is presented, with the aid of volcano plots to show the general principles for catalyst modifications to maximize the ORR.
Abstract: Palladium-based alloy materials as cathodes for the reduction of oxygen are regarded as potential substitutes for platinum-based catalysts in fuel cells. In this work, we present a scientometric analysis and critically review the use of Pd alloys for the oxygen reduction reaction (ORR). Through scientometric analysis, publication information, research fronts and hotspots are identified. For the critical review, reaction mechanisms in different media are discussed, with the aid of volcano plots to show the general principles for catalyst modifications to maximise the ORR. Influencing factors, including alloying, structure, strain and ligands, particle size, crystal facets and dealloying are considered with a view to informing the theoretical feasibility to enhance the ORR activity. In addition, Pd-based alloys synthesized by different methods are presented and compared in terms of ORR activities. Future research directions are discussed and possible approaches to mass production for industrialization are also proposed.
115 citations
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TL;DR: In this article, the results of a detailed experimental investigation of the near-wake (up to seven turbine diameters downstream) of a model horizontal axis tidal turbine (HATT) device in a large-scale recirculating water channel facility are reported.
114 citations
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TL;DR: In this article, a 20-year dataset collected from the Web of Science database is used to present a comprehensive knowledge map of the intellectual structure of the field of study of sustainability and financial performances in SMEs.
Abstract: Based on a 20-year dataset collected from the Web of Science database, this study aims to present a comprehensive knowledge map of the intellectual structure of the field of study of sustainability and financial performances in SMEs. A bibliometric analysis and systematic literature review method was employed by analyzing articles published between 1999 and 2018, using the VOSViewer software. The analyses provide an overview of articles, authors, the most influential journals, and themes of research. The results reveal the existence of three themes in research: the role of innovation and entrepreneurship their impact on sustainability in SMEs (cluster 1); CSR in the context of SMEs (cluster 2); and, green management and environmental issues for SMEs (cluster 3). In sum, this paper discusses prominent insights from the research analyses and recommends future research directions for the field.
114 citations
Authors
Showing all 2452 results
Name | H-index | Papers | Citations |
---|---|---|---|
David R. Williams | 178 | 2034 | 138789 |
David Scott | 124 | 1561 | 82554 |
Hugh S. Markus | 118 | 606 | 55614 |
Timothy E. Hewett | 116 | 531 | 49310 |
Wei Zhang | 96 | 1404 | 43392 |
Matthew Hall | 75 | 827 | 24352 |
Matthew C. Walker | 73 | 443 | 16373 |
James F. Meschia | 71 | 401 | 28037 |
Mark G. Macklin | 69 | 268 | 13066 |
John N. Lester | 66 | 349 | 19014 |
Christine J Nicol | 61 | 268 | 10689 |
Lei Shu | 59 | 598 | 13601 |
Frank Tanser | 54 | 231 | 17555 |
Simon Parsons | 54 | 462 | 15069 |
Christopher D. Anderson | 54 | 393 | 10523 |