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University of Medicine and Dentistry of New Jersey
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About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Pregnancy. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.
Topics: Population, Pregnancy, Poison control, Gene, Receptor
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TL;DR: The frequent association of DRS with other congenital anomalies suggests a teratogenic event occurring between the fourth to eighth week of gestation as an etiological factor.
208 citations
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TL;DR: The distribution of corticospinal projection neurons in adult rats was determined using a retrograde tracing technique using Horseradish peroxidase and an emulsifier and HRP-positive neurons were distributed in area 4 and rostral area 6/8 and medial area 3 and caudal area 2 (somatosensory cortices).
Abstract: The distribution of corticospinal projection neurons in adult rats was determined using a retrograde tracing technique. Horseradish peroxidase (HRP) and an emulsifier (Nonidet) were injected into the 5th and 6th segments of the cervical spinal cord. The greatest concentrations of HRP-positive neurons were distributed in area 4 and rostral area 6/8 (motor cortices) and medial area 3 and caudal area 2 (somatosensory cortices). The largest labeled neurons were in areas 4 and 3. HRP-positive neurons were absent or few in regions of motor and somatosensory fields which contained the face representation. Less dense concentrations of retrogradely labeled neurons were also in posterior parietal and association areas 14, 39 and 40, rostral occipital visual areas 18a and 18b, and anterior cingulate and prefrontal areas 24a, 24b, and 32. The topography of the corticospinal pathway was determined by injecting HRP without Nonidet into the cervical, upper thoracic, lower thoracic, or lumbar spinal cord. Although the distribution of labeled neurons decreased with distance down the spinal cord, the size of the corticospinal neurons in each cytoarchitectonic area was not significantly different regardless of where the injection was placed. For example, upper thoracic cord injections retrogradely labeled neurons in each of the regions containing neurons filled by cervical cord injections, however, lumbar injections retrogradely labeled neurons only in caudal areas 4 and 3 and in area 18b. The distribution of corticospinal neurons in rats is similar to the organization of the corticospinal system in higher animals. The origin of corticospinal neurons in occipital and cingulate cortices may be related to visuomotor and visceromotor control.
208 citations
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TL;DR: In this article, the authors assessed survival at life-threatening RBC hemoglobin concentration (Hb) in massively bleeding patients who do not receive red cells and found that PolyHeme should be useful in the early treatment of urgent blood loss and resolve the dilemma of unavailability of red cells.
Abstract: Background Human polymerized hemoglobin (PolyHeme, Northfield Laboratories, Evanston, IL) is a universally compatible, immediately available, disease-free, oxygen-carrying resuscitative fluid being developed as a red cell substitute for use in urgent blood loss. PolyHeme should be particularly useful when red cells may be temporarily unavailable. This article assesses survival at life-threatening RBC hemoglobin concentration ([Hb]) in massively bleeding patients who do not receive red cells. Study design There were 171 patients who received rapid infusion of 1 to 20 units (1,000 g, 10 L) of PolyHeme in lieu of red cells as initial oxygen-carrying replacement in trauma and urgent surgery. The protocol simulated the unavailability of red cells, and the progressive fall in RBC [Hb] in bleeding patients was quantified. Thirty-day mortality was compared with a historical control group of 300 surgical patients who refused red cells on religious grounds. Results A total of 171 patients received rapid infusion of 1 to 2 units (n = 45), 3 to 4 units (n = 45), 5 to 9 units (n = 47), or 10 to 20 units (n = 34) of PolyHeme. Forty patients had a nadir RBC [Hb] ≤3 g/dL (mean, 1.5 ± 0.7 g/dL). But total [Hb] was adequately maintained (mean, 6.8 ± 1.2 g/dL) because of plasma [Hb] added by PolyHeme. The 30-day mortality was 25.0% (10/40 patients) compared with 64.5% (20/31 patients) in historical control patients at these RBC [Hb] levels. Conclusions PolyHeme increases survival at life-threatening RBC [Hb] by maintaining total [Hb] in the absence of red cell transfusion. PolyHeme should be useful in the early treatment of urgent blood loss and resolve the dilemma of unavailability of red cells.
208 citations
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Northside Hospital1, Medical College of Wisconsin2, Johns Hopkins University3, University of South Florida4, University of Texas MD Anderson Cancer Center5, Geisinger Medical Center6, Thomas Jefferson University7, Georgetown University8, City of Hope National Medical Center9, Harvard University10, Memorial Sloan Kettering Cancer Center11, University of Cambridge12, Washington University in St. Louis13, University of Medicine and Dentistry of New Jersey14, University of Oxford15, Fred Hutchinson Cancer Research Center16
TL;DR: PB and BM grafts are suitable for haploidentical transplantation with the post-transplant cyclophosphamide approach but with differing patterns of treatment failure, and must be validated in a randomized prospective comparison with adequate follow-up.
Abstract: PurposeT-cell–replete HLA-haploidentical donor hematopoietic transplantation using post-transplant cyclophosphamide was originally described using bone marrow (BM). With increasing use of mobilized peripheral blood (PB), we compared transplant outcomes after PB and BM transplants.Patients and MethodsA total of 681 patients with hematologic malignancy who underwent transplantation in the United States between 2009 and 2014 received BM (n = 481) or PB (n = 190) grafts. Cox regression models were built to examine differences in transplant outcomes by graft type, adjusting for patient, disease, and transplant characteristics.ResultsHematopoietic recovery was similar after transplantation of BM and PB (28-day neutrophil recovery, 88% v 93%, P = .07; 100-day platelet recovery, 88% v 85%, P = .33). Risks of grade 2 to 4 acute (hazard ratio [HR], 0.45; P < .001) and chronic (HR, 0.35; P < .001) graft-versus-host disease were lower with transplantation of BM compared with PB. There were no significant differences ...
207 citations
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TL;DR: In vitro "ligament analogs" fabricated by seeding high-strength resorbable collagen fiber scaffolds with intraarticular or extraarticular rabbit fibroblasts may be useful as implants for ACL reconstruction surgery and continue viable after implantation into the knee joint.
Abstract: We fabricated “ligament analogs” in vitro, by seeding highstrength resorbable collagen fiber scaffolds with intraarticular (anterior cruciate ligament, ACL) or extraarticular (patellar tendon, PT) rabbit fibroblasts. Fibroblasts attached, proliferated, and secreted new collagen on the ligament analogs in vitro. Fibroblast function depended on the tissue culture substrate (ligament analog vs. tissue culture plate) and the origin of the fibroblasts (ACL vs. PT). PT fibroblasts proliferated more rapidly than ACL fibroblasts when cultured on ligament analogs. Collagen synthesis by ACL and PT fibroblasts was approximately tenfold greater on ligament analogs than on tissue culture plates. The composition, structure, and geometry of the collagen fiber scaffolds may promote collagen synthesis within ligament analogs in vitro., Ligament analogs roughly approximate the structure and strength of native ligament tissue. Ongoing in vivo studies suggest that autogenous fibroblast-seeded ligament analogs remain viable after implantation into the knee joint. With further development, ligament analogs may be useful as implants for ACL reconstruction surgery. © 1995 John Wiley & Sons, Inc.
207 citations
Authors
Showing all 14639 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Virginia M.-Y. Lee | 194 | 993 | 148820 |
Danny Reinberg | 145 | 342 | 68201 |
Michael F. Holick | 145 | 767 | 107937 |
Tasuku Honjo | 141 | 712 | 88428 |
Arnold J. Levine | 139 | 485 | 116005 |
Aaron T. Beck | 139 | 536 | 170816 |
Charles J. Yeo | 136 | 672 | 76424 |
Jerry W. Shay | 133 | 639 | 74774 |
Chung S. Yang | 128 | 560 | 56265 |
Paul G. Falkowski | 127 | 378 | 64898 |
Csaba Szabó | 123 | 958 | 61791 |
William C. Roberts | 122 | 1117 | 55285 |
Bryan R. Cullen | 121 | 371 | 50901 |
John R. Perfect | 119 | 573 | 52325 |