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University of Medicine and Dentistry of New Jersey
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About: University of Medicine and Dentistry of New Jersey is a based out in . It is known for research contribution in the topics: Population & Pregnancy. The organization has 14634 authors who have published 19610 publications receiving 1041794 citations.
Topics: Population, Pregnancy, Poison control, Gene, Receptor
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TL;DR: In higher eukaryotes, translation is modulated at the level of initiation by five aspects of mRNA structure: (i) the m7G cap; (ii) the primary sequence or context surrounding the AUG codon; (iii) the position of the Aug codon, i.e. whether or not it s “first”; (iv) secondary structure both upstream and downstream from the AUU; and (v) leader length.
1,908 citations
TL;DR: Limiting autophagy under conditions of nutrient limitation can restore cell death to apoptosis-refractory tumors, but this necrosis is associated with inflammation and accelerated tumor growth.
1,888 citations
TL;DR: This Review focuses on pharmacological strategies to attenuate the toxic effects of peroxynitrite, which include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
Abstract: Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition of its formation or its decomposition have been shown to be of benefit include vascular diseases, ischaemia-reperfusion injury, circulatory shock, inflammation, pain and neurodegeneration In this Review, we first discuss the biochemistry and pathophysiology of peroxynitrite and then focus on pharmacological strategies to attenuate the toxic effects of peroxynitrite These include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases
1,804 citations
TL;DR: It is found that proinflammatory cytokines are required to induce immunosuppression by MSCs through the concerted action of chemokines and NO.
1,789 citations
TL;DR: The increased use of neuroimaging techniques in patients with MS has advanced the understanding of structural and functional changes in the brain that are characteristic of this disease, although much remains to be learned.
Abstract: Summary Multiple sclerosis (MS) is a progressive disease of the CNS that is characterised by widespread lesions in the brain and spinal cord. MS results in motor, cognitive, and neuropsychiatric symptoms, all of which can occur independently of one another. The common cognitive symptoms include deficits in complex attention, efficiency of information processing, executive functioning, processing speed, and long-term memory. These deficits detrimentally affect many aspects of daily life, such as the ability to run a household, participate fully in society, and maintain employment—factors that can all affect the overall quality of life of the patient. The increased use of neuroimaging techniques in patients with MS has advanced our understanding of structural and functional changes in the brain that are characteristic of this disease, although much remains to be learned. Moreover, examination of efforts to treat the cognitive deficits in MS is still in the early stages.
1,707 citations
Authors
Showing all 14639 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John Q. Trojanowski | 226 | 1467 | 213948 |
| Virginia M.-Y. Lee | 194 | 993 | 148820 |
| Danny Reinberg | 145 | 342 | 68201 |
| Michael F. Holick | 145 | 767 | 107937 |
| Tasuku Honjo | 141 | 712 | 88428 |
| Arnold J. Levine | 139 | 485 | 116005 |
| Aaron T. Beck | 139 | 536 | 170816 |
| Charles J. Yeo | 136 | 672 | 76424 |
| Jerry W. Shay | 133 | 639 | 74774 |
| Chung S. Yang | 128 | 560 | 56265 |
| Paul G. Falkowski | 127 | 378 | 64898 |
| Csaba Szabó | 123 | 958 | 61791 |
| William C. Roberts | 122 | 1117 | 55285 |
| Bryan R. Cullen | 121 | 371 | 50901 |
| John R. Perfect | 119 | 573 | 52325 |