Showing papers in "Journal of Controlled Release in 2004"

TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.

TL;DR: The results clearly suggested that the genipin-cross-linked NOCC/alginate hydrogel could be a suitable polymeric carrier for site-specific protein drug delivery in the intestine.

TL;DR: The combination of mechanical barriers based on non-woven nanofibrous biodegradable scaffolds and their capability for local delivery of antibiotics increases their desired utility in biomedical applications, particularly in the prevention of post-surgical adhesions and infections.

TL;DR: Diblock copolymers of poly(e-caprolactone) (PCL) and monomethoxy poly(ethylene glycol) (MPEG) with various compositions were synthesized and exhibited time-delayed cytotoxicity in human MCF-7 breast cancer cells.

TL;DR: Although non-viral vectors are less efficient than viral ones, they have the advantages of safety, simplicity of preparation and high gene encapsulation capability.

TL;DR: With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.

TL;DR: Flow cytometry and confocal image analysis revealed that folate conjugated mixed micelles exhibited far greater extent of cellular uptake than folate unconjugated micells against KB cells over-expressing folate receptors on the surface, and showed higher cytotoxicity than DOX, suggesting that folATE receptor medicated endocytosis of the micelle played an important role in transporting an increased amount of DOX within cells.

TL;DR: Confocal laser scanning microscopy was used to visualize the distribution of non-biodegradable, fluorescent, polystyrene nanoparticles across porcine skin and revealed that these non-follicular structures did not offer an alternative penetration pathway for the polymer vectors, whose transport was clearly impeded by the stratum corneum.

TL;DR: DSC and PXRD analysis showed that clozapine is dispersed in SLN in an amorphous state and the release pattern of drug is analyzed and found to follow Weibull and Higuchi equations.

TL;DR: Folate-targeted doxorubicin nano-aggregates could be a potentially useful delivery system for folate-receptor-positive cancer cells, according to results in a human tumor xenograft nude mouse model.

TL;DR: Results suggest that certain antibiotics are able to bind/chelate with calcium, resulting in a better incorporation into the CHA coating and a slower release, which might be used to prevent post-surgical infections and to promote bone-bonding of orthopedic devices.

TL;DR: The investigated SLN appear as thin platelets with oil spots sticking on the surface and very short diffusion pathways in platelets, increased water-lipid interfaces and low drug incorporation in crystalline lipids are the drawback of SLN and NLC compared to conventional nanoemulsions.

TL;DR: The L-arginine-grafted-PAMAM dendrimer possesses the potential to be a novel gene delivery carrier for gene therapy, and the complex composed of PAMAM-Arg/DNA showed increased gene delivery potency compared to native P AMAM d endrimer and PAM AM-Lys.

TL;DR: A new HPLC method was employed for calculated gentamicin amount in the delivery test, which requires a small amount of sample, very advisable in these kinds of assays.

TL;DR: Transdermal delivery of desmopressin by Macroflux is a safe and efficient alternative to currently available routes of administration and patches were well tolerated, suggesting the absence of a skin depot.

TL;DR: This study investigates the mechanism of the solvent elimination from the emulsion droplets and its influence on the particle morphology, encapsulation and release behavior of microparticles in double emulsion formulations.

TL;DR: Confocal microscopy coupled with in vivo and in vitro skin permeation results demonstrated that nanoparticles containing solutes penetrated mainly via shunt routes like hair follicles, resulting in skin absorption of solutes.

TL;DR: The results indicate that the studied microemulsion systems, especially ME6, may be promising vehicles for the transdermal delivery of triptolide.

TL;DR: This article reviews cationic lipids for gene therapy from chemistry viewpoint and classifies these compounds as monovalent cationIC lipids, polyvalent cATIONiclipids, catedic polymers, guanidine containing compounds, cationi peptides and cholesterol containing compounds and hope to provide suggestions on the development of these compounds through the discussion.

TL;DR: The engineered nanoparticles may have potential in tumor-targeted delivery of Gd thereby enhancing the therapeutic success of NCT, and the benefits of folate ligand coating were to facilitate tumor cell internalization and retention in the tumor tissue.

TL;DR: Doxorubicin-loaded long-circulating liposomes modified with the monoclonal nucleosome (NS)-specific 2C5 antibody that recognizes a broad variety of tumors via the tumor cell surface-bound NSs kill various tumor cells in vitro with the efficiency higher than non-targeted doxorubo-loaded liposome modifications.

TL;DR: PHSN have a promising future in controlled drug delivery applications and was applied as a carrier to study the controlled release behaviors of Brilliant Blue F, which exhibited a typical sustained release pattern without any burst effect.

TL;DR: It was hypothesized that PX NPs could mask paclitaxel characteristics and thus limit its binding to p-gp, which consequently would lead to higher brain and tumor cell uptake of the otherwise effluxed drug.

TL;DR: These mucoadhesive formulations offer many advantages in comparison to traditional treatments and can be proposed as a new therapeutic tool against dental and buccal diseases and disturbs.

TL;DR: Investigation of the effect of the size of biodegradable microparticles (monolithic dispersions) on the release rate of an incorporated drug in a quantitative way revealed that the degradation behavior of the matrix forming polymer was not significantly affected by the sizes of the devices and that autocatalytic effects do not seem to play a major role.

TL;DR: MEND, having octaarginine on the envelope as a device for membrane penetration to enhance cellular uptake, showed a 1000-fold higher transfection activity than DPC and represents a promising non-viral gene delivery system.

TL;DR: Evaluating a novel polymeric solubilizer for anticancer drugs, i.e., poly(N-vinylpyrrolidone)-block-poly(D,L-lactide) (PVP-b-PDLLA), showed in mice and rabbits that the areas under the plasma concentration-time curves were inversely related to PM drug loading.

TL;DR: Assessment of the feasibility of using affinity-based delivery systems to release neurotrophin-3 in a controlled manner from fibrin gels as a therapy for spinal cord injury found that heparin concentration modulates diffusion-based release of NT-3.

TL;DR: Eleven enhancements to the delivery scheme suggest the potential use of these hybrids for a variety of drug therapies, including potential site-directing of the nanohybrids.

TL;DR: The results suggest that the alginate-VEGF delivery system may be useful in the development of vascular tissue engineering and wound healing applications.