Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
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Journal ArticleDOI
Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires.
Nuray Aslan,Levi B. Watkin,Anna Gil,Rabinarayan Mishra,Fransenio G. Clark,Raymond M. Welsh,Dario Ghersi,Katherine Luzuriaga,Liisa K. Selin +8 more
TL;DR: The severity of acute infectious mononucleosis (AIM), an Epstein-Barr virus (EBV)-induced disease prevalent in young adults but not children, is associated with increased frequencies of T cells cross-reactive to EBV and the commonly acquired influenza A virus (IAV).
Journal ArticleDOI
Microbial programming of systemic innate immunity and resistance to infection.
TL;DR: The mechanistic basis for systemic effects of microbial exposure, whether it is by the microbiota or pathogenic organisms, and how they modulate host defenses to infection by other microbes are described.
Journal ArticleDOI
The non-specific effects of vaccines and other childhood interventions: the contribution of INDEPTH Health and Demographic Surveillance Systems
Osman Sankoh,P. Welaga,C. Debpuur,C. Zandoh,S. Gyaase,M. A. Poma,Martin K. Mutua,S. M. A. Hanifi,C. Martins,E. Nebie,M. Kagone,J. B. Emina,Peter Aaby +12 more
TL;DR: INDEPTH member centres are proposed to extend their routine data collection platform to better measure the use and effects of childhood interventions, and may come to play a stronger role in defining health research issues of relevance to low-income countries.
Journal ArticleDOI
Co-administration of BCG and Diphtheria-tetanus-pertussis (DTP) Vaccinations May Reduce Infant Mortality More Than the WHO-schedule of BCG First and Then DTP. A Re-analysis of Demographic Surveillance Data From Rural Bangladesh.
TL;DR: Co-administration of BCG and DTP may further reduce mortality and all observational studies support this trend, so co-administering ofBCG andDTP should be tested in randomised trials.
Journal ArticleDOI
Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes.
Pablo Garcia-Valtanen,A. Martinez-Lopez,Azucena López-Muñoz,Melissa Bello-Perez,Regla María Medina-Gali,Maria del Mar Ortega-Villaizan,Monica Varela,Antonio Figueras,Victoriano Mulero,Beatriz Novoa,Amparo Estepa,Julio Coll +11 more
TL;DR: Evidence is presented that indicates that rag1−/− zebra fish acquire an antiviral alert state while they reach adulthood in the absence of adaptive immunity, and some of mammalian trained immunity are present in lower vertebrates.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
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How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.