Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
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Book ChapterDOI
Animal nutrition and immunity in pigs and poultry
TL;DR: Novel interdisciplinary research programs, integrating fields like animal nutrition, mucosal immunology, transgenerational development of immune competence, and husbandry conditions are urgently needed to lead to systems that produce more resilient animals, with increased immune competence that are better able to cope with their environmental challenges.
Journal ArticleDOI
Retesting the hypothesis that early Diphtheria-Tetanus-Pertussis vaccination increases female mortality: An observational study within a randomised trial.
Marcus Kjær Sørensen,Frederik Schaltz-Buchholzer,Andreas Møller Jensen,Sebastian Nielsen,Ivan Monteiro,Peter Aaby,Christine Stabell Benn +6 more
TL;DR: In this article, the effect of early-DTPV vaccination on female mortality was investigated in a randomized trial in Guinea-Bissau, where 2,398 infants were randomized 1:1 to early-Bacillus Calmette-Guerin (BCG) or delayed-BCG (standard practice for LW neonates) and visited at 2, 6 and 12 months of age to assess nutritional and vaccination status.
Journal ArticleDOI
[BCG, muramylpeptides, trained immunity (part I): linkages in the light of the COVID-19 pandemic].
TL;DR: In this article, the authors highlighted the proven and proposed linkages between Bacillus CalmetteGurin (BCG), MPs, NOD2 and trained immunity in the light of the COVID-19 pandemic and highlighted the potential for preclinical and clinical studies of MPs as potential drugs for nonspecific prevention of SARS-CoV-2 infection and/or other respiratory infections in risk groups during the pandemic.
Journal ArticleDOI
Retesting the hypothesis that early Diphtheria-Tetanus-Pertussis vaccination increases female mortality: An observational study within a randomised trial
TL;DR: In this article , the effect of having early-DTP versus delayed DTP on all-cause mortality between the 2-and 6-month visits in Guinea-Bissau, was investigated.
Journal ArticleDOI
Non-specific effects of maternal and offspring rabies vaccination on mortality and antibiotic use in a Danish pig herd: A randomized trial.
Kristoffer Jarlov Jensen,Lola Kathe Tolstrup,Darryn L. Knobel,Peter Aaby,Gregers Jungersen,Lars Erik Larsen,Charlotte Sonne Kristensen,Christine Stabell Benn +7 more
TL;DR: In this paper, the authors investigated the effect of non-live rabies vaccine in piglets and the potential modifying effect of maternal priming with the vaccine on treatment risk, and concluded that prior sow vaccination did not affect piglet mortality.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.