Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
More filters
Journal ArticleDOI
Characteristics of severely malnourished under-five children immunized with Bacillus Calmette-Guérin following Expanded Programme on Immunization schedule and their outcomes during hospitalization at an urban diarrheal treatment centre, Bangladesh
M. M. Ackhter,Abu Sadat Mohammad Sayeem Bin Shahid,Tahmeed Ahmed,P. Palit,Irin Parvin,Md Zahidul Islam,Tahmina Alam,Shamsun Nahar Shaima,Lubaba Shahrin,Farzana Afroze,Monira Sarmin,Shoeb Bin Islam,Zubair Akhtar,Mohammod Jobayer Chisti,Fahmida Chowdhury +14 more
TL;DR: BCG vaccination and breastfeeding were found to be protective for the development of severe sepsis in hospitalized severely malnourished under-five children which underscores the importance of continuation of BCG vaccination at birth and breastfeeding up to two years of age.
Journal ArticleDOI
Implementation and assessment of vaccination programmes: the importance of vaccination sequence for overall health outcomes.
TL;DR: To maximise the impact of current vaccination programmes on child health, increased emphasis should be placed on receiving MV after DTP, and modified recommendations for catch-up vaccinations for children who do not follow the recommended schedule are likely to result in improvements in child health.
Book ChapterDOI
Trained Immunity-Based Vaccines: A Ready-to-Act Strategy to Tackle Viral Outbreaks
TL;DR: Trained immunity-based vaccines (TIbVs) as discussed by the authors can be used during viral outbreaks to provide non-specific protection but also to enhance adaptive specific immune responses, which are dependent on functional reprogramming of innate immune cells, leading to an enhanced nonspecific response towards different pathogens, including viruses.
Immunisation for old adults in Europe: scientific and social strategies FEAM
Ana M. Matos,Mihai G. Netea +1 more
Journal ArticleDOI
A Shot at Economic Prosperity: Long-term Effects of India’s Childhood Immunization Program on Earnings and Consumption Expenditure
TL;DR: A shot at economic prosperity: Long-term effects of India's childhood immunization program on earnings and consumption expenditure was discussed in this article , where Summan, Nandi, and Bloom investigated the long-term effect of childhood vaccination on India's economy.
References
More filters
Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.