Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
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Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes
b4migpd985,b4migpd985 +1 more
TL;DR: In this article , the authors demonstrate cellular transcriptional programs in response to four different inducers of trained immunity in monocyte populations at single-cell resolution, and identify three monocyte subpopulations upon the induction of training immunity, and replicated these findings in an in vivo study.
Journal ArticleDOI
Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens.
Vijayashree Mysore,Xavier Cullere,Matthew L. Settles,Xinge Ji,Michael W. Kattan,Michaël Desjardins,Blythe Durbin-Johnson,Tal Gilboa,Lindsey R. Baden,David R. Walt,Andrew H. Lichtman,Lara Jehi,Tanya N. Mayadas +12 more
TL;DR: In this article, the authors investigated whether prior MMR or tetanus-diphtheria-pertussis (Tdap) vaccination elicits cross-reactive T-cells that mitigate COVID-19.
Journal ArticleDOI
Simultaneous vaccination with MMR and DTaP-IPV-Hib and rate of hospital admissions with any infections: A nationwide register based cohort study.
TL;DR: A nationwide retrospective cohort study of Danish children aged 15 months to 4 years finds a higher rate of admissions for lower respiratory infections for MMR + DTaP-IPV-Hib vs MMR alone.
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Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor α and β Repertoires.
Anna Gil,Larisa Kamga,Ramakanth Chirravuri-Venkata,Nuray Aslan,Fransenio G. Clark,Dario Ghersi,Katherine Luzuriaga,Liisa K. Selin +7 more
TL;DR: Understanding of how TCR-peptide-MHC complex interactions drive repertoire selection can be used to develop optimal strategies for vaccine design or generation of appropriate adoptive immunotherapies for viral infections in transplant settings or for cancer.
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MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG.
TL;DR: MTBVAC as mentioned in this paper is one of these candidates, which contains the antigen repertoire of M. tuberculosis and is now poised to initiate Phase 3 efficacy trials in newborns in TB-endemic countries.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
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Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
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Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.