Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
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Journal ArticleDOI
Maternal BCG primes for enhanced health benefits in the newborn
TL;DR: In this paper , a large cohort of BCG-vaccinated newborns from Guinea-Bissau were assessed using binomial regression providing adjusted Risk Ratio (aRRs).
Journal ArticleDOI
COVID-19 in children: reasons for uneventful clinical course
Sweni Shah,Ramachandran Meenakshisundaram,Subramanian Senthilkumaran,Ponniah Thirumalaikolundusubramanian +3 more
TL;DR: Coronavirus disease 2019 (COVID-19) infection is reported among neonates and children; however, this population has far fewer secondary complications than adults and recurrent viral infections in young children may offer some protection against CO VID-19.
Journal ArticleDOI
Timeliness of DTaP-IPV-Hib Vaccination and Development of Atopic Dermatitis Between 4 Months and 1 Year of Age—Register-Based Cohort Study
Lise Gehrt,Lise Gehrt,Andreas Rieckmann,Andreas Rieckmann,Nicholas Kiraly,Aksel Karl Georg Jensen,Aksel Karl Georg Jensen,Peter Aaby,Peter Aaby,Christine Stabell Benn,Christine Stabell Benn,Signe Sørup,Signe Sørup +12 more
TL;DR: The hypothesis that delayed vaccination with DTaP is associated with reduced risk of developing new cases of AD after 4 months of age is supported and the dose-dependent relationship strengthens the evidence of a causal relationship.
Journal ArticleDOI
Infectious diseases and cognition: do we have to worry?
Virgilio Hernández-Ruiz,Luc Letenneur,Tamás Fülöp,Catherine Helmer,Claire Roubaud-Baudron,José Alberto Avila-Funes,Hélène Amieva +6 more
TL;DR: In this article , the authors reviewed current knowledge on cognitive outcomes of infectious diseases in older adults, and emphasized the importance of considering cognition as a domain of interest in its own rights in these diseases.
Book ChapterDOI
Age-Specific Differences in the Severity of COVID-19 Between Children and Adults: Reality and Reasons.
Amir Tajbakhsh,Khojaste Rahimi Jaberi,Seyed Mohammad Gheibi Hayat,Mehrdad Sharifi,Thomas P. Johnston,Paul C. Guest,Mohammad Hasan Jafari,Amirhossein Sahebkar +7 more
TL;DR: In this article, the authors attempted to identify rational explanations about age-related differences as reported in different studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.