Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
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Mycobacterial growth inhibition is associated with trained innate immunity
Simone A. Joosten,Krista E. van Meijgaarden,Sandra M. Arend,Corine Prins,Fredrik Oftung,Gro Ellen Korsvold,Sandra V. Kik,Rob J.W. Arts,Reinout van Crevel,Mihai G. Netea,Tom H. M. Ottenhoff +10 more
TL;DR: Data indicate that CXCR3 ligands are associated with trained immunity and are critical factors in controlling mycobacterial outgrowth, which is the result of trained immunity mediated by a CXCL10-producing nonclassical CD14dim monocyte subset.
Journal ArticleDOI
Immunological memory within the innate immune system
TL;DR: The evidence for immunological memory in lower organisms and within specific cell subsets of the innate immune system are summarized and a special focus is given to recent findings in both mouse and humans for specificity and memory in natural killer cells.
Journal ArticleDOI
Vaccinology: time to change the paradigm?
Christine Stabell Benn,Christine Stabell Benn,Christine Stabell Benn,Ane Bærent Fisker,Ane Bærent Fisker,Andreas Rieckmann,Andreas Rieckmann,Signe Sørup,Signe Sørup,Peter Aaby,Peter Aaby +10 more
TL;DR: Current observations and contradictions are described and six emerging principles that might explain them are defined, suggesting that live vaccines enhance resistance towards unrelated infections and non-live vaccines enhance the susceptibility of girls to unrelated infections.
Journal ArticleDOI
Innate-adaptive immunity interplay and redox regulation in immune response
TL;DR: The cellular and molecular interplay of innate-adaptive immune systems is described and its underlying molecular basis would lead to the identification of therapeutic targets for immunological and inflammatory disease.
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Observational studies and the difficult quest for causality: lessons from vaccine effectiveness and impact studies.
TL;DR: A fresh look at the time-trend studies often dismissed as 'ecological' studies, the only observational study design that can measure the overall effect of a vaccination programme, and are in fact already an important part of the evidence base for several vaccines currently in use.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
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How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
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Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.