Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
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Journal ArticleDOI
Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau.
Olga Bengård Hansen,Amabelia Rodrigues,Cesario Martins,Andreas Rieckmann,Christine Stabell Benn,Christine Stabell Benn,Peter Aaby,Peter Aaby,Ane Bærent Fisker,Ane Bærent Fisker,Ane Bærent Fisker +10 more
TL;DR: The decline in the vaccinated group may have been smaller than the decline inThe non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.
Journal ArticleDOI
Mortality risk among frail neonates might be associated with maternal BCG scar status: Observational study from Guinea-Bissau.
Frederik Schaltz-Buchholzer,Peter Aaby,Isaquel B Silva,Ivan Monteiro,Tobias R. Kollmann,Nelly Amenyogbe,Morten Bjerregaard-Andersen,Christine Stabell Benn +7 more
TL;DR: It is indicated that maternal BCG might be associated with reduced all-cause NICU mortality, and if confirmed elsewhere, this finding would have substantial ramifications for global health.
Journal ArticleDOI
Safety of Multiple Antigen Exposure in the Childhood Immunization Schedule.
Sean T. O’Leary,Yvonne Maldonado +1 more
Journal ArticleDOI
Assessing the effect of BCG revaccination on long-term mortality
Posted ContentDOI
High diversity, turnover, and structural constraints characterize TCR α and β repertoire selection
Larisa Kamga,Anna Gil,I. Song,Chirravuri R,Nuray Aslan,Dario Ghersi,Lawrence J. Stern,Liisa K. Selin,Katherine Luzuriaga +8 more
TL;DR: It is shown that persistent EBV-specific clonotypes account for only 9% of uniqueClonotypes but are highly expanded in acute infectious mononucleosis, and have distinct antigen-specific public features that drive selection into convalescence.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.