Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
More filters
Journal ArticleDOI
Coronavirus Disease (COVID-19) in Children: Indian Perspectives
Subramanian Senthilkumaran,Ramachandran Meenakshisundaram,Sweni Shah,Ponniah Thirumalaikolundusubramanian +3 more
TL;DR: From the point of epidemiology, reporting and testing of children for COVID-19 are less, which lead to undersampling and under-reporting of the disease, which facilitates transmission of the organism by rendering children as carriers.
Book ChapterDOI
Bio inspired materials for nonviral vaccine delivery
TL;DR: In this article, the authors discuss the recent advancements in the applications of different bio-inspired materials as efficient carriers for the delivery of vaccines, including hydrophilic and hydrophobic materials.
Pertinence des méthodes vaccinales actuelles vis-à-vis de l'immunosénescence et nouvelles stratégies développées
TL;DR: In this paper, the authors discuss the effect of vaccination on the health of the population in terms of its immunosenescence, i.e., l’immunosity against new defis a vaccination.
Journal ArticleDOI
Regulation of the immune system by the insulin receptor in health and disease
Priya Makhijani,Paulo José Basso,Yi Tao Chan,Nan Chen,Jordan J. Baechle,Saad Khan,David Furman,Sue Tsai,Daniel E. Weiner +8 more
TL;DR: In this paper , the authors summarize current understanding of the InsR signaling pathways in different immune cell subsets and their impact on cellular metabolism, differentiation, and effector versus regulatory function.
References
More filters
Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.