Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
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Journal ArticleDOI
Trained immunity: A program of innate immune memory in health and disease
Mihai G. Netea,Leo A. B. Joosten,Eicke Latz,Kingston H. G. Mills,Gioacchino Natoli,Hendrik G. Stunnenberg,Luke A. J. O'Neill,Ramnik J. Xavier +7 more
TL;DR: Proof-of-principle experimental studies support the hypothesis that trained immunity is one of the main immunological processes that mediate the nonspecific protective effects against infections induced by vaccines, such as bacillus Calmette-Guérin or measles vaccination.
Journal ArticleDOI
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Shih-Chin Cheng,Jessica Quintin,Robert A. Cramer,Kelly M. Shepardson,Sadia Saeed,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Joost H.A. Martens,Nagesha Appukudige Rao,Ali Aghajanirefah,Ganesh R. Manjeri,Yang Li,Daniela C. Ifrim,Rob J.W. Arts,Brian M. J. W. van der Veer,Peter M.T. Deen,Colin Logie,Luke A. J. O'Neill,Peter H.G.M. Willems,Frank L. van de Veerdonk,Jos W. M. van der Meer,Aylwin Ng,Aylwin Ng,Leo A. B. Joosten,Cisca Wijmenga,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea +28 more
TL;DR: The identification of glycolysis as a fundamental process in trained immunity further highlights a key regulatory role for metabolism in innate host defense and defines a potential therapeutic target in both infectious and inflammatory diseases.
Journal ArticleDOI
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Sadia Saeed,Jessica Quintin,Hindrik H. D. Kerstens,Nagesha A.S. Rao,Ali Aghajanirefah,Filomena Matarese,Shih-Chin Cheng,Jacqueline M. Ratter,Kim Berentsen,Martijn van der Ent,Nilofar Sharifi,Eva M. Janssen-Megens,Menno ter Huurne,Amit Mandoli,Tom van Schaik,Aylwin Ng,Aylwin Ng,Frances Burden,Kate Downes,Mattia Frontini,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Willem H. Ouwehand,Jos W. M. van der Meer,Leo A. B. Joosten,Cisca Wijmenga,Joost H.A. Martens,Ramnik J. Xavier,Ramnik J. Xavier,Colin Logie,Mihai G. Netea,Hendrik G. Stunnenberg +31 more
TL;DR: The epigenetic and transcriptional programs of monocyte differentiation to macrophages that distinguish tolerant and trained macrophage phenotypes are uncovered, providing a resource to further understand and manipulate immune-mediated responses.
Journal ArticleDOI
Defining trained immunity and its role in health and disease
Mihai G. Netea,Mihai G. Netea,Jorge Domínguez-Andrés,Luis B. Barreiro,Luis B. Barreiro,Triantafyllos Chavakis,Triantafyllos Chavakis,Maziar Divangahi,Maziar Divangahi,Elaine Fuchs,Leo A. B. Joosten,Jos W. M. van der Meer,Musa M. Mhlanga,Musa M. Mhlanga,Willem J. M. Mulder,Willem J. M. Mulder,Niels P. Riksen,Andreas Schlitzer,Joachim L. Schultze,Christine Stabell Benn,Joseph C. Sun,Joseph C. Sun,Ramnik J. Xavier,Ramnik J. Xavier,Eicke Latz,Eicke Latz,Eicke Latz +26 more
TL;DR: A group of leaders in the field define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
Journal ArticleDOI
Mitochondria are the powerhouses of immunity.
TL;DR: This work has shown that Krebs cycle intermediates such as succinate, fumarate and citrate engage in processes related to immunity and inflammation, in both innate and adaptive immune cells.
References
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Journal ArticleDOI
Inverse association between melanoma and previous vaccinations against tuberculosis and smallpox: results of the FEBIM study.
Anisette Pfahlberg,K. F. Kölmel,John M. Grange,Giuseppe Mastrangelo,Bernd Krone,I.N. Botev,Marianne Niin,Claus Seebacher,Daniel Lambert,Raphael Shafir,Daniela Schneider,E. M. Kokoschka,Ulrich R. Kleeberg,Wolfgang Uter,Olaf Gefeller +14 more
TL;DR: It is concluded that bacille Calmette-Guérin vaccination and vaccinia vaccination may lower melanoma risk and current immunologic theory of melanoma development provides a sound basis for understanding the biologic plausibility of the findings.
Journal ArticleDOI
Cross-Reactive Memory CD8+ T Cells Alter the Immune Response to Heterologous Secondary Dengue Virus Infections in Mice in a Sequence-Specific Manner
TL;DR: It is demonstrated that cross-reactive T cells from a primary infection alter the immune response during a heterologous secondary infection.
Book
Immunization status and child survival in rural Ghana
TL;DR: Data from the Navrongo Demographic Surveillance System a longitudinal population registration system in northern Ghana is used to examine all-cause mortality among vaccinated and unvaccinated children under 5 years of age and indicates a need for further research in developing countries on the all- Cause mortality impact of these vaccines in particular DPT vaccine.
Journal ArticleDOI
Bacille-Calmette-Guerin vaccination and the development of allergic disease in children: a randomized, prospective, single-blind study.
T. J. Steenhuis,W.M.C. van Aalderen,Nanne Bloksma,Frans P. Nijkamp,J. van der Laag,H. van Loveren,Ger T. Rijkers,W. Kuis,M. O. Hoekstra +8 more
TL;DR: This work has shown an increase in the prevalence of allergic diseases in countries with a so‐called western lifestyle may be due to a decrease in exposure to infectious agents in early life.
Journal Article
Sex-Specific Differences in Mortality after High-Titre Measles Immunization in Rural Senegal
Peter Aaby,Badara Samb,François Simondon,Kim Knudsen,Awa Marie Coll Seck,John V. Bennett,Lauri E. Markowitz,P. Rhodes,H Whittle +8 more
TL;DR: For children aged 5-10 months the high-titre measles vaccine did not increase mortality relative to unvaccinated children who had received placebo, and the long-term survival after high-Titre Measles immunization at 5 months of age with that following routine immunization with standard- titre vaccine at 10 months ofAge.