Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
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Vaccinations against smallpox and tuberculosis are associated with better long-term survival: a Danish case-cohort study 1971–2010
Andreas Rieckmann,Andreas Rieckmann,Marie Villumsen,Signe Sørup,Line Klingen Haugaard,Line Klingen Haugaard,Henrik Ravn,Henrik Ravn,Adam Roth,Adam Roth,Jennifer L. Baker,Jennifer L. Baker,Christine Stabell Benn,Christine Stabell Benn,Peter Aaby,Peter Aaby,Peter Aaby +16 more
TL;DR: Vaccines with beneficial non-specific effects may reduce overall mortality even after the target diseases are eradicated, and are associated with better long-term survival.
Journal ArticleDOI
Impact of the influenza vaccine on COVID-19 infection rates and severity.
TL;DR: In this paper, the role of the influenza vaccine in COVID-19 susceptibility and severity was evaluated in patients who received a laboratory test for COVID19 and those who did not.
Journal ArticleDOI
Therapeutic host-directed strategies to improve outcome in tuberculosis.
TL;DR: A comprehensive, up-to-date review of host-directed therapeutics (HDTs) to improve clinical outcome in tuberculosis (TB) disease is presented, summarizing all compounds, primarily repurposed drugs, tested in human clinical trials.
Journal ArticleDOI
BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers.
Magali Noval Rivas,Magali Noval Rivas,Joseph E. Ebinger,Min Wu,Nancy Sun,Jonathan Braun,Kimia Sobhani,Jennifer E. Van Eyk,Susan Cheng,Moshe Arditi,Moshe Arditi +10 more
TL;DR: Seroprevalence of anti-SARS-CoV-2 IgG as well as incidence of self-reported clinical symptoms associated with COVID-19 were significantly decreased among HCWs with a history of BCG vaccination compared to those withoutBCG vaccination.
Journal ArticleDOI
COVID-19 in children: where do we stand?
TL;DR: In this paper, the authors reviewed the epidemiologic and clinical features of children with SARS-CoV-2 infection and concluded that the true prevalence of asymptomatic SARS CoV2 infection is most likely underestimated.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.