Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
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Trained Immunity-Based Vaccines: A Ready-to-Act Strategy to Tackle Viral Outbreaks
TL;DR: This chapter aims to illustrate how trained immunity-based vaccines could tackle the above-mentioned situations derived from viral outbreaks, reviewing the potential of available TIbVs in such urgent situations with a special mention to COVID-19.
Journal ArticleDOI
A comprehensive framework for considering additional unintended consequences in economic evaluation
TL;DR: This work builds on previous checklists to provide analysts with a comprehensive framework to justify the inclusion or exclusion of effects, supporting the use of current guidelines, to ensure any unintended effects are considered.
Book ChapterDOI
Innate Immunity and Neuroinflammation in Neuropsychiatric Conditions Including Autism Spectrum Disorders: Role of Innate Immune Memory
TL;DR: A role of innate immune memory (trained immunity vs. tolerance) in neuroinflammation in association with neuropsychiatric conditions including autism spectrum disorders (ASD) is summarized.
Journal ArticleDOI
The role of neutrophils in trained immunity
TL;DR: The principle of trained immunity represents innate immune memory due to sustained, mainly epigenetic, changes triggered by endogenous or exogenous stimuli in bone marrow (BM) progenitors and their innate immune cell progeny, thereby triggering elevated responsiveness against secondary stimuli as discussed by the authors .
Journal ArticleDOI
Can earlier BCG vaccination reduce early infant mortality? Study protocol for a cluster randomised trial in Guinea-Bissau.
Sanne Marie Thysen,Aksel Karl Georg Jensen,Amabelia Rodrigues,Igualdino da Silva Borges,Peter Aaby,Peter Aaby,Christine Stabell Benn,Ane Bærent Fisker +7 more
TL;DR: Using Cox-proportional hazards models, this trial will test whether BCG and OPV provided at a single home visit can reduce early infant mortality up to 60 days in Bandim Health Project's urban and rural health and demographic surveillance systems.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.