Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
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Trained immunity: A program of innate immune memory in health and disease
Mihai G. Netea,Leo A. B. Joosten,Eicke Latz,Kingston H. G. Mills,Gioacchino Natoli,Hendrik G. Stunnenberg,Luke A. J. O'Neill,Ramnik J. Xavier +7 more
TL;DR: Proof-of-principle experimental studies support the hypothesis that trained immunity is one of the main immunological processes that mediate the nonspecific protective effects against infections induced by vaccines, such as bacillus Calmette-Guérin or measles vaccination.
Journal ArticleDOI
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Shih-Chin Cheng,Jessica Quintin,Robert A. Cramer,Kelly M. Shepardson,Sadia Saeed,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Joost H.A. Martens,Nagesha Appukudige Rao,Ali Aghajanirefah,Ganesh R. Manjeri,Yang Li,Daniela C. Ifrim,Rob J.W. Arts,Brian M. J. W. van der Veer,Peter M.T. Deen,Colin Logie,Luke A. J. O'Neill,Peter H.G.M. Willems,Frank L. van de Veerdonk,Jos W. M. van der Meer,Aylwin Ng,Aylwin Ng,Leo A. B. Joosten,Cisca Wijmenga,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea +28 more
TL;DR: The identification of glycolysis as a fundamental process in trained immunity further highlights a key regulatory role for metabolism in innate host defense and defines a potential therapeutic target in both infectious and inflammatory diseases.
Journal ArticleDOI
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Sadia Saeed,Jessica Quintin,Hindrik H. D. Kerstens,Nagesha A.S. Rao,Ali Aghajanirefah,Filomena Matarese,Shih-Chin Cheng,Jacqueline M. Ratter,Kim Berentsen,Martijn van der Ent,Nilofar Sharifi,Eva M. Janssen-Megens,Menno ter Huurne,Amit Mandoli,Tom van Schaik,Aylwin Ng,Aylwin Ng,Frances Burden,Kate Downes,Mattia Frontini,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Willem H. Ouwehand,Jos W. M. van der Meer,Leo A. B. Joosten,Cisca Wijmenga,Joost H.A. Martens,Ramnik J. Xavier,Ramnik J. Xavier,Colin Logie,Mihai G. Netea,Hendrik G. Stunnenberg +31 more
TL;DR: The epigenetic and transcriptional programs of monocyte differentiation to macrophages that distinguish tolerant and trained macrophage phenotypes are uncovered, providing a resource to further understand and manipulate immune-mediated responses.
Journal ArticleDOI
Defining trained immunity and its role in health and disease
Mihai G. Netea,Mihai G. Netea,Jorge Domínguez-Andrés,Luis B. Barreiro,Luis B. Barreiro,Triantafyllos Chavakis,Triantafyllos Chavakis,Maziar Divangahi,Maziar Divangahi,Elaine Fuchs,Leo A. B. Joosten,Jos W. M. van der Meer,Musa M. Mhlanga,Musa M. Mhlanga,Willem J. M. Mulder,Willem J. M. Mulder,Niels P. Riksen,Andreas Schlitzer,Joachim L. Schultze,Christine Stabell Benn,Joseph C. Sun,Joseph C. Sun,Ramnik J. Xavier,Ramnik J. Xavier,Eicke Latz,Eicke Latz,Eicke Latz +26 more
TL;DR: A group of leaders in the field define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
Journal ArticleDOI
Mitochondria are the powerhouses of immunity.
TL;DR: This work has shown that Krebs cycle intermediates such as succinate, fumarate and citrate engage in processes related to immunity and inflammation, in both innate and adaptive immune cells.
References
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Journal ArticleDOI
T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
Michael A. Brehm,Amelia K. Pinto,Amelia K. Pinto,Keith A. Daniels,Jonathan P. Schneck,Raymond M. Welsh,Liisa K. Selin +6 more
TL;DR: Findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8+ T cell responses elicited by subsequent viral infections.
Journal ArticleDOI
Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung.
Hong D. Chen,Armando E. Fraire,Isabelle Joris,Michael A. Brehm,Raymond M. Welsh,Liisa K. Selin +5 more
TL;DR: The participation of pre-existing memory T cells specific to unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pathogen.
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Evidence for macrophage-mediated protection against lethal Candida albicans infection.
Francesco Bistoni,Anna Vecchiarelli,Elio Cenci,Paolo Puccetti,Pierfrancesco Marconi,Antonio Cassone +5 more
TL;DR: It was found that administration of PCA-2 was accompanied by an increase in the number of peripheral blood polymorphonuclear cells and by the activation in the spleen of cells with highly candidacidal activity in vitro, which conferred considerable protection against subsequent CA-6 challenge.
Journal ArticleDOI
Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial
Peter Aaby,Cesario Martins,May-Lill Garly,Carlito Balé,Andreas Andersen,Amabelia Rodrigues,Henrik Ravn,Ida Maria Lisse,Christine Stabell Benn,Hilton Whittle +9 more
TL;DR: The results may indicate that a two dose schedule with Edmonston-Zagreb measles vaccine given at 4.5 and 9 months of age has beneficial non-specific effects on children’s survival, particularly for girls and for children who have not received neonatal vitamin A.
Journal ArticleDOI
Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells.
TL;DR: It is demonstrated directly that HCV-specific T cells could be induced in vivo by IV infection, exemplify that host responses to an infectious agent are influenced by cross-reactive memory cells induced by past exposure to heterologous viruses, which could have important consequences for vaccine development.