Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
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Vaccine-Induced Cellular Immunity against Bordetella pertussis: Harnessing Lessons from Animal and Human Studies to Improve Design and Testing of Novel Pertussis Vaccines
TL;DR: A recent review as discussed by the authors summarises current knowledge on vaccine-induced cellular immune responses, based on mucosal and systemic data collected within experimental animal and human vaccine studies, and describes key factors that may influence cell-mediated immunity and how antigen-specific responses are measured quantitatively and qualitatively, at both cellular and molecular levels.
Journal ArticleDOI
Association between vaccinations and clinical manifestations in children with COVID-19
Shijian Liu,Chunhui Yuan,Jianfei Lin,Wenqi Gao,Dan Tian,Xiaonan Cai,Jiajun Yuan,Feiyan Xiang,Yan Yang,Xinru Huang,Ruizhen Li,Yun Xiang,Hongmei Shan,Li Zhao,Bin Dong,Min Zhou,Shilu Tong,Shilu Tong,Tongxin Chen,Jianbo Shao,Liebin Zhao,Han Xiao +21 more
TL;DR: The aim of the present study was to explore the association of vaccinations and clinical manifestations in pediatric patients with Coronavirus Disea and the role of vaccinations in clinical manifestations.
Posted ContentDOI
Effectiveness of influenza vaccination against SARS-CoV-2 infection among healthcare workers in Qatar
TL;DR: In this paper , the authors conducted a matched, test-negative, case-control study to estimate effectiveness of influenza vaccination, using Abbott's quadrivalent Influvac Tetra vaccine, against SARS-CoV-2 infection and against severe COVID-19.
Journal ArticleDOI
Oral Vaccines-Types, Delivery Strategies, Current and Future Perspectives
TL;DR: Oral immunization is considered the most convenient route of vaccination rather than any other route due to their abundance of facilities over the traditional vaccines.
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Bacillus Calmette-Guérin vaccination, thymic size, and thymic output in healthy newborns
Nina Marie Birk,Thomas Nørrelykke Nissen,Vera Zingmark,Jesper Kjaergaard,Lisbeth Marianne Thøstesen,Poul-Erik Kofoed,Lone Graff Stensballe,Andreas Andersen,Susanne Dam Nielsen,Christine Stabell Benn,Ole Pryds,Dorthe Lisbeth Jeppesen +11 more
TL;DR: The positive association between thymic output, lymphocytes, reduced risk of infections, and TI/TWI suggests that assessment of TI/ TWI by ultrasound may be a predictor of the immunological capacity in the newborn.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
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Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.