Journal ArticleDOI
A small jab – a big effect: nonspecific immunomodulation by vaccines
TLDR
New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.About:
This article is published in Trends in Immunology.The article was published on 2013-09-01. It has received 406 citations till now. The article focuses on the topics: Acquired immune system & Immune system.read more
Citations
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Journal ArticleDOI
Out-of-Sequence Vaccinations With Measles Vaccine and Diphtheria-Tetanus-Pertussis Vaccine: A Reanalysis of Demographic Surveillance Data From Rural Bangladesh
Clara Clipet-Jensen,Andreas Andersen,Aksel Karl Georg Jensen,Aksel Karl Georg Jensen,Peter Aaby,Peter Aaby,K. Zaman +6 more
TL;DR: The negative effects of non-live DTP with or after live MV are not explained merely by selection bias and support a live-vaccine-last policy where DTP should not be given with or before measles vaccine (MV).
Peer ReviewDOI
Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies
TL;DR: Routine adult vaccinations are associated with a significant reduction in dementia risk and may be an effective strategy for dementia prevention.
Journal ArticleDOI
Early response of monocyte-derived macrophages from vaccinated and non-vaccinated goats against in vitro infection with Mycobacterium avium subsp. paratuberculosis.
Noive Arteche-Villasol,D. Gutiérrez-Expósito,Raquel Vallejo,José Espinosa,Natalia Elguezabal,Iraia Ladero-Auñon,M. Royo,María del Carmen Ferreras,Julio Benavides,Valentín Pérez Pérez +9 more
TL;DR: In this article, the effect of Silirum® vaccination in the early immune response of caprine monocyte-derived macrophages (CaMOs) was investigated, showing that vaccination modifies the immune response and microbiocidal activity of CaMOs against paratuberculosis.
Journal ArticleDOI
BCG for the prevention of food allergy — exploring a new use for an old vaccine
TL;DR: Australia now has the highest documented prevalence of childhood food allergy in the world and theories to explain this rise include changes in the timing of food introduction, epigenetic changes related to environmental factors, and alterations in micronutrient status (particularly of vitamin D).
Journal ArticleDOI
Immunization enhances the natural antibody repertoire.
Dylan Beinart,Daniel Ren,Cinthia Pi,Susan Poulton,Zoie E. Holzknecht,Chelsea Swanson,William Parker +6 more
TL;DR: It is suggested that immunization may have at least one unforeseen benefit, enhancing networks of natural antibodies that may be important in such processes as wound repair and tumor surveillance, where decreased exposure to the environment may be associated with a weakened natural antibody repertoire.
References
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Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Systemic acquired resistance
W.E. Durrant,Xinnian Dong +1 more
TL;DR: A model describing the sequence of events leading from initial infection to the induction of defense genes is presented and exciting new data suggest that the mobile signal for SAR might be a lipid molecule.
Journal ArticleDOI
How to Grow a Mind: Statistics, Structure, and Abstraction
TL;DR: This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.