Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation
Anyuan He,Xiaowen Chen,Min Tan,Yali Chen,Dongliang Lu,Xiangyu Zhang,John M. Dean,Babak Razani,Irfan J. Lodhi +8 more
TLDR
Peroxisome-derived acetyl-CoA is identified as a key metabolic regulator of autophagy that controls hepatic lipid homeostasis that restricts autophagic degradation of lipids.About:
This article is published in Molecular Cell.The article was published on 2020-07-02 and is currently open access. It has received 74 citations till now. The article focuses on the topics: Lipid droplet & Autophagy.read more
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Autophagy in major human diseases
Daniel J. Klionsky,Giulia Petroni,Ravi K. Amaravadi,Eric H. Baehrecke,Andrea Ballabio,Andrea Ballabio,Patricia Boya,José Manuel Bravo-San Pedro,Ken Cadwell,Francesco Cecconi,Francesco Cecconi,Augustine M.K. Choi,Augustine M.K. Choi,Mary E. Choi,Mary E. Choi,Charleen T. Chu,Patrice Codogno,Patrice Codogno,María Isabel Colombo,Ana Maria Cuervo,Vojo Deretic,Ivan Dikic,Zvulun Elazar,Eeva-Liisa Eskelinen,Gian Maria Fimia,David A. Gewirtz,Douglas R. Green,Malene Hansen,Marja Jäättelä,Terje Johansen,Gábor Juhász,Vassiliki Karantza,Claudine Kraft,Guido Kroemer,Nicholas T. Ktistakis,Sharad Kumar,Sharad Kumar,Carlos López-Otín,Kay F. Macleod,Frank Madeo,Jennifer Martinez,Alicia Meléndez,Alicia Meléndez,Noboru Mizushima,Christian Münz,Josef M. Penninger,Josef M. Penninger,Rushika M. Perera,Mauro Piacentini,Mauro Piacentini,Fulvio Reggiori,David C. Rubinsztein,Kevin M. Ryan,Junichi Sadoshima,Laura Santambrogio,Luca Scorrano,Hans-Uwe Simon,Hans-Uwe Simon,Anna Katharina Simon,Anne Simonsen,Anne Simonsen,Alexandra Stolz,Nektarios Tavernarakis,Nektarios Tavernarakis,Sharon A. Tooze,Tamotsu Yoshimori,Junying Yuan,Junying Yuan,Zhenyu Yue,Qing Zhong,Lorenzo Galluzzi,Federico Pietrocola +71 more
TL;DR: In this paper, preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Journal ArticleDOI
Regulation and metabolic functions of mTORC1 and mTORC2
TL;DR: In this article, the authors discuss the key discoveries and recent findings on the regulation and metabolic functions of the mTOR complexes, highlighting findings from cancer models but also discuss other examples of mTOR-mediated metabolic reprogramming occurring in stem and immune cells, type 2 diabetes/obesity, neurodegenerative disorders and aging.
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FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases.
Erik J. Tillman,Tim Rolph +1 more
TL;DR: Among this wave of therapeutic mechanisms targeting the underlying pathogenesis of NASH, the hormone fibroblast growth factor 21 (FGF21) holds considerable promise; it decreases liver fat and hepatocyte injury while suppressing inflammation and fibrosis across multiple preclinical studies.
Journal ArticleDOI
Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity.
TL;DR: In this paper, the authors discuss recent advances in understanding lipid metabolism with a focus on catabolism, synthesis, and signaling, and provide a framework for understanding newly identified targets regulating lipid homeostasis with implications for ameliorating metabolic diseases.
Journal ArticleDOI
Peroxisomes as cellular adaptors to metabolic and environmental stress.
TL;DR: In this article, a review of molecular mechanisms through which peroxisomes regulate metabolic and environmental stress is presented, and it is shown that other products, such as acetyl-CoA and ether lipids, are also important for metabolic adaptation to stress.
References
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Autophagy regulates lipid metabolism
Rajat Singh,Susmita Kaushik,Yongjun Wang,Youqing Xiang,Inna Novak,Masaaki Komatsu,Keiji Tanaka,Ana Maria Cuervo,Mark J. Czaja +8 more
TL;DR: A previously unknown function for autophagy in regulating intracellular lipid stores (macrolipophagy) is identified that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome.