Advances in long noncoding RNAs: identification, structure prediction and function annotation.
TLDR
Recent, state-of-the-art advances in the three levels (the primary sequence, the secondary structure and the function annotation) of the lncRNAs research are reviewed, as well as computational methods for lncRNA data analysis.Abstract:
Long noncoding RNAs (lncRNAs), generally longer than 200 nucleotides and with poor protein coding potential, are usually considered collectively as a heterogeneous class of RNAs. Recently, an increasing number of studies have shown that lncRNAs can involve in various critical biological processes and a number of complex human diseases. Not only the primary sequences of many lncRNAs are directly interrelated to a specific functional role, strong evidence suggests that their secondary structures are even more interrelated to their known functions. As functional molecules, lncRNAs have become more and more relevant to many researchers. Here, we review recent, state-of-the-art advances in the three levels (the primary sequence, the secondary structure and the function annotation) of the lncRNA research, as well as computational methods for lncRNA data analysis.read more
Citations
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Journal ArticleDOI
Mechanisms of long noncoding RNA function in development and disease
TL;DR: Examples illustrating the versatility of lncRNAs in gene control, development and differentiation, as well as in human disease are discussed.
Book ChapterDOI
History, Discovery, and Classification of lncRNAs.
TL;DR: The many discoveries that led to the study of lncRNAs are discussed, from Friedrich Miescher's "nuclein" in 1869 to the elucidation of the human genome and transcriptome in the early 2000s, to focus on the biological relevance during lncRNA evolution and describe their basic features as genes and transcripts.
Journal ArticleDOI
LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases.
TL;DR: The new developments in LncRNADisease 2.0 include an over 40-fold lncRNA-disease association enhancement compared with the previous version, and providing the transcriptional regulatory relationships among lnc RNA, mRNA and miRNA.
Journal ArticleDOI
Long non-coding RNA: Classification, biogenesis and functions in blood cells.
Swati Dahariya,Indira Paddibhatla,Santosh Kumar,Sanjeev Raghuwanshi,Adithya Pallepati,Ravi Kumar Gutti +5 more
TL;DR: The current status of knowledge on lncRNAs classification, biogenesis and its role in blood cells is summarized.
Journal ArticleDOI
Perspectives of long non-coding RNAs in cancer
TL;DR: This systematic review outlines the vivid role of lncRNAs in cancer context and opens up future conceptual applications.
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TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
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