Association between Trichomonas vaginalis and vaginal bacterial community composition among reproductive-age women.
Rebecca M. Brotman,L. Latey Bradford,Melissa D. Conrad,Pawel Gajer,Kevin A. Ault,Ligia Peralta,Larry J. Forney,Jane M. Carlton,Zaid Abdo,Jacques Ravel +9 more
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TLDR
T. vaginalis was associated with vaginal microbiota consisting of low proportions of lactobacilli and high proportions of Mycoplasma, Parvimonas, Sneathia, and other anaerobes, and the association was evaluated by exact logistic regression.Abstract:
Objectives
Some vaginal bacterial communities are thought to prevent infection by sexually transmitted organisms. Prior work demonstrated that the vaginal microbiota of reproductive-age women cluster into five types of bacterial communities; 4 dominated by Lactobacillus species (L. iners, L. crispatus, L. gasseri, L. jensenii), and one (termed community state type (CST) IV) lacking significant numbers of lactobacilli and characterized by higher proportions of Atopobium, Prevotella, Parvimonas, Sneathia, Gardnerella, Mobiluncus, and other taxa. We sought to evaluate the relationship between vaginal bacterial composition and Trichomonas vaginalis.read more
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Dynamics and associations of microbial community types across the human body
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TL;DR: The results demonstrate that even with the considerable intra- and interpersonal variation in the human microbiome, this variation can be partitioned into community types that are predictive of each other and are probably the result of life-history characteristics.
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The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women
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TL;DR: Differences in the composition and stability of the microbial community between pregnant and non-pregnant women were observed and can serve as the basis to study the relationship between the vaginal microbiome and adverse pregnancy outcomes.
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TL;DR: It is conclusively shown that lactobacilli-dominated VMB are associated with a healthy vaginal micro-environment and that bacterial vaginosis (BV) is best described as a polybacterial dysbiosis.
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Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota.
TL;DR: The results suggest that when lactobacilli dominate the vaginal microbiota, women have significantly more lactic acid-mediated protection against infections than currently believed.
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Microbiome Data Distinguish Patients with Clostridium difficile Infection and Non-C. difficile-Associated Diarrhea from Healthy Controls
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TL;DR: Improved discriminatory ability of microbiome-based models confirms the theory that factors affecting the microbiome influence CDI, and demonstrates that several community types and the loss of several bacterial populations, including Bacteroides, Lachnospiraceae, and Ruminococcaceae, are associated with CDI.
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