Association of Exercise Therapy and Reduction of Pain Sensitivity in Patients With Knee Osteoarthritis: A Randomized Controlled Trial
Marius Henriksen,L. Klokker,Thomas Graven-Nielsen,Cecilie Bartholdy,Tanja Schjødt Jørgensen,Elisabeth Bandak,Bente Danneskiold-Samsøe,Robin Christensen,Henning Bliddal +8 more
TLDR
In this paper, the effects of exercise on pressure-pain sensitivity in patients with knee OA were investigated in a randomized controlled trial, where participants were assigned to 12 weeks of supervised exercise therapy (ET; 36 sessions) or a no attention control group (CG).Abstract:
Objective
Exercise has beneficial effects on pain in knee osteoarthritis (OA), yet the underlying mechanisms are unclear. The purpose of this study was to investigate the effects of exercise on pressure–pain sensitivity in patients with knee OA.
Methods
In a randomized controlled trial, participants were assigned to 12 weeks of supervised exercise therapy (ET; 36 sessions) or a no attention control group (CG). Pressure–pain sensitivity was assessed by cuff pressure algometry on the calf of the most symptomatic leg. The coprimary outcomes were pressure–pain thresholds (PPTs) and cumulated visual analog scale pain scores during constant pressure for 6 minutes at 125% of the PPT as a measure of temporal summation (TS) of pressure–pain. Secondary outcomes included self-reported pain using the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire. Analyses were based on the “per-protocol” population (participants following the protocol).
Results
Sixty participants were randomized (31 in ET group, 29 in CG), and the per-protocol population included 48 participants (25 in ET group, 23 in CG). At followup, mean group differences in the change from baseline were 3.1 kPa (95% confidence interval [95% CI] 0.2, 6.0; P = 0.038) for the PPT, 2,608 mm × seconds (95% CI 458, 4,758; P = 0.019) for TS, and 6.8 points (95% CI 1.2, 12.4; P = 0.018) for KOOS pain, all in favor of ET.
Conclusion
Pressure–pain sensitivity, TS, and self-reported pain are reduced among patients completing a 12-week supervised exercise program compared to a no attention CG. These results demonstrate beneficial effects of exercise on basic pain mechanisms and further exploration may provide a basis for optimized treatment.read more
Citations
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Journal ArticleDOI
Consensus on Exercise Reporting Template (CERT): Explanation and Elaboration Statement.
TL;DR: The aim is to present the final template and provide an Explanation and Elaboration Statement to operationalise the 16-item Consensus on Exercise Reporting Template (CERT), which has the potential to increase clinical uptake of effective exercise programmes, enable research replication, reduce research waste and improve patient outcomes.
Journal ArticleDOI
2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis
Anne-Kathrin Rausch Osthoff,Karin Niedermann,Jürgen Braun,Jo Adams,Nina Brodin,Hanne Dagfinrud,Tuncay Duruöz,Bente Appel Esbensen,Klaus-Peter Günther,Emailie Hurkmans,Carsten Bogh Juhl,Norelee Kennedy,Uta Kiltz,Keegan Knittle,Michael T. Nurmohamed,S. Pais,G. Severijns,Thijs Swinnen,Irene A Pitsillidou,Louise Warburton,Zhivko Yankov,Theodora P. M. Vliet Vlieland +21 more
TL;DR: Evidence and expert opinion inform these recommendations to provide guidance in the development, conduct and evaluation of PA-interventions and promotion in people with iA and OA.
Journal ArticleDOI
Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena.
TL;DR: A review explores and discusses current evidence on central mechanisms underlying exercised‐induced pain and analgesia and suggests opioids, serotonin and NMDA mechanisms acting in rostral ventromedial medulla promote analgesia associated with exercise.
Journal ArticleDOI
Educating patients about the benefits of physical activity and exercise for their hip and knee osteoarthritis. Systematic literature review.
TL;DR: In this paper, the authors highlight the role of patient education about physical activity and exercise in the treatment of hip and knee osteoarthritis (OA) using a systematic literature review from the Cochrane Library, PubMed and Wiley Online Library.
Journal ArticleDOI
The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: strengthening exercise programs
Lucie Brosseau,Jade Taki,Brigit Desjardins,Odette Thevenot,Marlene Fransen,George A. Wells,Aline Mizusaki Imoto,Karine Toupin-April,Marie D. Westby,Inmaculada C Álvarez Gallardo,Wendy Gifford,Lucie Laferrière,Prinon Rahman,Laurianne Loew,Gino De Angelis,Sabrina Cavallo,Shirin M. Shallwani,Ala' S Aburub,Kim L Bennell,Martin van der Esch,Milena Simic,Sara McConnell,Alison R. Harmer,Glen P. Kenny,Gail Paterson,Jean-Philippe Regnaux,Marie-Martine Lefèvre-Colau,Linda McLean +27 more
TL;DR: There are a variety of choices for strengthening exercise programs with positive recommendations for healthcare professionals and knee osteoarthritis patients and a need to develop combined behavioral and muscle-strengthening strategies to improve long-term maintenance of regular strengthening exercises.
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TL;DR: This update of the CONSORT statement improves the wording and clarity of the previous checklist and incorporates recommendations related to topics that have only recently received recognition, such as selective outcome reporting bias.
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TL;DR: The SPIRIT 2013 Explanation and Elaboration paper provides important information to promote full understanding of the checklist recommendations and strongly recommends that this explanatory paper be used in conjunction with the SPIRit Statement.
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TL;DR: The KOOS proved reliable, responsive to surgery and physical therapy, and valid for patients undergoing anterior cruciate ligament reconstruction, and can be used to evaluate the course of knee injury and treatment outcome.
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The anti-inflammatory effect of exercise
TL;DR: It is suggested that myokines may be involved in mediating the health-beneficial effects of exercise and that these in particular are involved in the protection against chronic diseases associated with low-grade inflammation such as diabetes and cardiovascular diseases.
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