Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Self-rated health and vital exhaustion, but not depression, is related to inflammation in women with coronary heart disease.
TL;DR: In conclusion, inflammatory activity, assessed by IL-6 and hsCRP levels, was associated with vital exhaustion and self-rated health in CHD women, and may provide further evidence for a possible psychoneuroimmune link between subjective well-being and CHD.
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Reduced expression of regulator of G-protein signaling 2 (rgs2) in hypertensive patients increases calcium mobilization and Erk1/2 phosphorylation induced by angiotensin Ii
Andrea Semplicini,Livia Lenzini,Michelangelo Sartori,Italia Papparella,Lorenzo A. Calò,Elisa Pagnin,Giacomo Strapazzon,Clara Benna,Rodolfo Costa,Angelo Avogaro,Giulio Ceolotto,Achille C. Pessina +11 more
TL;DR: Low expression of RGS2 contributes to increased G-protein-coupled signaling in hypertensive patients and in those with the G allele, independently of the blood pressure status.
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Endothelial dysfunction and inflammation—is there a link?
TL;DR: C-reactive protein (CRP), a sensitive and objective marker of one non-traditional risk factor, inflammation, has been shown to be associated to CVD in both predialysis and dialysis patients populations.
Journal ArticleDOI
Adhesion molecules, catecholamines and leucocyte redistribution during and following exercise.
TL;DR: There is growing evidence that catecholamines, acting through a cyclic adenosine monophosphate second messenger system, play an important role in modifying the surface expression of adhesion molecules.
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Elevated C-reactive protein levels are associated with postoperative events in patients undergoing lower extremity vein bypass surgery.
Christopher D. Owens,Paul M. Ridker,Michael Belkin,Allen D. Hamdan,Frank B. Pomposelli,Frank W. LoGerfo,Mark A. Creager,Michael S. Conte +7 more
TL;DR: The inflammatory biomarkers of hsCRP, fibrinogen, and SAA correlate with peripheral arterial disease severity at presentation in patients undergoing lower extremity bypass, suggesting a potential relationship between inflammation and outcomes afterLower extremity vein bypass surgery.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
Journal ArticleDOI
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.