Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
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C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women
TL;DR: The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying persons at risk for cardiovascular events.
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The metabolic syndrome
TL;DR: The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated, and a proinflammatory state probably contributes to the metabolic syndrome.
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The importance of the ratio of omega-6/omega-3 essential fatty acids.
TL;DR: In this article, a lower omega-6/omega-3 ratio in women with breast cancer was associated with decreased risk, whereas a higher ratio of omega-3 PUFA had no effect.
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Journal Article
Induction of interleukin-1 production by ligands binding to the scavenger receptor in human monocytes and the THP-1 cell line.
TL;DR: It is demonstrated that stimulation of the scavenger receptor activates monocytes to produce interleukin-1 (IL-1) and a synergistic effect of protein kinase C and cyclic AMP-mediated signal transduction pathways in scavengers receptor-mediated IL-1 production is suggested.
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Blood flow and the localization of atherosclerotic plaques.
TL;DR: Studies of blood, particularly in diabetes, will be able to characterize the factors that control the magnitude of permeability-enhancing multi-directional stress and suggest new ways to slow atherogenesis and ultimately prevent atherosclerosis.
Book ChapterDOI
Prospective Studies of Homocysteine and Cardiovascular Disease
Meir J. Stampfer,Petra Verhoef +1 more
TL;DR: The link between vascular disease and elevated homocysteine Levels has been recognized for more than 30 years, and an association with moderately elevated levels has been suspected for 20 years, but a strong positive relationship between moderate hyperhomocysteinemia and risk of vascular disease is suggested.
Journal ArticleDOI
Stimulation of macrophage urokinase expression by polyanions is protein kinase C-dependent and requires protein and RNA synthesis.
TL;DR: Highly charged polyanionic ligands of the scavenger receptor trigger macrophage secretion of urokinase-type plasminogen activator (uPA) and fucoidan bound uPA and had a small stimulatory affect on uPA activity.
Journal ArticleDOI
T-cell cytokines may control the balance of functionally distinct macrophage populations
TL;DR: It is concluded that mature macrophage phenotype is ‘plastic’ and under the control of T‐cell‐derived mediators.