Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Plasma Resistin Levels and Risk of Myocardial Infarction and Ischemic Stroke
Cornelia Weikert,Sabine Westphal,Klaus Berger,Jutta Dierkes,Matthias Möhlig,Joachim Spranger,Eric B. Rimm,Eric B. Rimm,Stefan N. Willich,Heiner Boeing,Tobias Pischon +10 more
TL;DR: The data suggest that high plasma resistin levels are associated with an increased risk of MI but not with risk of IS, and further studies are needed to evaluate the predictive value of plasmaresistin levels for cardiovascular disease.
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C-reactive protein levels are influenced by common IL-1 gene variations
Peter B. Berger,Joseph P. McConnell,Martha E. Nunn,Kenneth S. Kornman,Julian Sorrell,Katherine Stephenson,Gordon W. Duff +6 more
TL;DR: The data indicate that IL-1 gene polymorphisms known to affect the inflammatory response are highly related to plasma levels of CRP and fibrinogen in patients referred for coronary angiography.
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Cell type-specific localization of human cardiac S1P receptors.
David Mazurais,Philippe Robert,Bernard Gout,Isabelle Berrebi-Bertrand,Marie Paule Laville,Thierry Calmels +5 more
TL;DR: The present results provide new insight into the expression pattern of S1P receptor in human cardiovascular tissues, indicating a differential pattern of expression for these receptors in human vessels.
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Nonthrombogenic Approaches to Cardiovascular Bioengineering
Song Li,Jeffrey J.D. Henry +1 more
TL;DR: The advances in antithrombogenic approaches for surface modifications and cardiovascular tissue engineering are discussed.
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Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy
Richard S. Lee,Kazuhiko Yamada,Stuart L. Houser,Karl L. Womer,M.E. Maloney,H.S Rose,Mohamed H. Sayegh,Joren C. Madsen +7 more
TL;DR: Results definitively link indirect allorecognition and cardiac allograft vasculopathy, and immunized MHC inbred miniature swine with synthetic polymorphic peptides spanning the α1 domain of an allogeneic donor-derived swine leukocyte antigen class I gene.
References
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Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.