Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
Citations
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Modulation of endothelial cell activation in sickle cell disease: a pilot study
TL;DR: It is suggested that endothelial cell activation state can be modified and down-regulated in vivo by sulfasalazine.
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Fibrinogen, Other Putative Markers of Inflammation, and Weight Gain in Middle-aged Adults—The ARIC Study
Bruce Bartholow Duncan,Maria Inês Schmidt,Maria Inês Schmidt,Lloyd E. Chambless,Aaron R. Folsom,Myra A. Carpenter,Gerardo Heiss +6 more
TL;DR: Findings suggest that inflammatory processes play a role in the development of the metabolic syndrome and cardiovascular disease in part through stimulation of weight gain.
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Relationship of serum uric acid to measures of endothelial function and atherosclerosis in healthy adults
Dogan Erdogan,Hakan Gullu,Mustafa Caliskan,Erkan Yildirim,Muhammet Bilgi,Taner Ulus,Nurzen Sezgin,Haldun Muderrisoglu +7 more
TL;DR: High brachial artery resting diameter, FMD, carotid IMT, AoD, AoSI and AoEM were studied in healthy subjects with UA concentrations in physiological range for predictors for development and/or progression of atherosclerosis.
Journal ArticleDOI
Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies.
TL;DR: This review summarizes the current knowledge on the role of 12/15-LOX in inflammation and various human diseases, including cardiovascular, renal, neurological and metabolic disorders.
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The role of inflammation in vascular injury and repair
TL;DR: The mechanisms that regulate endothelial cell migration, smooth muscle cell activation, and extracellular matrix protein production are described, all of which are key components in the inflammatory response to vascular injury.
References
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Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.