Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Journal ArticleDOI
Interleukin-10 Inhibits Intimal Hyperplasia After Angioplasty or Stent Implantation in Hypercholesterolemic Rabbits
Laurent J. Feldman,Luc Aguirre,Marianne Ziol,Jean-Pierre Bridou,Nathalie Nevo,Jean-Baptiste Michel,P. Gabriel Steg +6 more
TL;DR: The potent attenuation of in-stent intimal growth by rhu IL-10 and its favorable toxicity profile suggest that rhuIL-10 may be useful in the prevention of in -stent restenosis.
Journal ArticleDOI
Vascular Effects of Novel Adipocytokines: Focus on Vascular Contractility and Inflammatory Responses
TL;DR: Recent findings on the vascular effects of 5 newly identified adipocytokines are summarized, with a special focus on 1) vascular contractile reactivity, and 2) vascular inflammatory response/injury.
Journal ArticleDOI
Differential inflammatory responses in aging and disease: TNF-α and IL-6 as possible biomarkers
David de Gonzalo-Calvo,Kim Neitzert,María Fernández,Ignacio Vega-Naredo,Beatriz Caballero,Marina García-Macia,Francisco Suárez,María Josefa Rodríguez-Colunga,Juan José Solano,Ana Coto-Montes +9 more
TL;DR: TNF-alpha, the first element in the cytokine cascade, was significantly increased in the aged population, implying that aging is accompanied by a gradual increase in this inflammatory biomarker, and IL-6 was not associated with aging, but it was highly elevated under hypoxia conditions in elderly subjects.
Journal ArticleDOI
Studies of LDL oxidation following α-, γ-, or δ-tocotrienyl acetate supplementation of hypercholesterolemic humans
Dawn O’Byrne,Scott M. Grundy,Lester Packer,Sridevi Devaraj,K. Baldenius,P. P. Hoppe,K. Kraemer,Ishwarlal Jialal,Maret G. Traber +8 more
TL;DR: It is demonstrated that tocotrienyl acetate supplements are hydrolyzed, absorbed, and detectable in human plasma, and α-T3 may be potent in decreasing LDL oxidizability.
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Protective role against restenosis from an interleukin-1 receptor antagonist gene polymorphism in patients treated with coronary stenting
Adnan Kastrati,Werner Koch,Peter B. Berger,Julinda Mehilli,Katherine Stephenson,Franz-Josef Neumann,Nicolas von Beckerath,Corinna Böttiger,Gordon W. Duff,Albert Schömig +9 more
TL;DR: Allele 2 of the IL-1ra gene was associated with a lower incidence of restenosis after coronary stenting, particularly in younger patients, and this finding supports a role of inflammation in the development of restanosis after stent placement.
References
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Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
Journal ArticleDOI
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.