Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
Reads0
Chats0
TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
Citations
More filters
Journal ArticleDOI
Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.
Carmen Argmann,Carmen Argmann,Jane Y. Edwards,Cynthia G. Sawyez,Caroline O'Neil,Robert A. Hegele,Robert A. Hegele,J. Geoffrey Pickering,J. Geoffrey Pickering,Murray W. Huff,Murray W. Huff +10 more
TL;DR: Atorvastatin induces cholesterol efflux through a molecular cascade involving inhibition of RhoA signaling, leading to increased peroxisome proliferator activated receptor γ activity, enhanced LXR activation, increased ABCA1 expression, and cholesterol eff Lux, indicating that statins can regulate foam cell formation.
Journal ArticleDOI
Clinical Aspects and Management of Cytomegalovirus Infection
J.G.P Sissons,A.J Carmichael +1 more
TL;DR: Current approaches to the clinical management of HCMV disease, and how understanding the biology of the virus may affect these are discussed.
Journal ArticleDOI
Oxidative stress and endothelial dysfunction: clinical evidence and therapeutic implications.
TL;DR: An association between oxidative stress and endothelial function is shown, especially in patients with renovascular hypertension and patients with Gilbert syndrome as a model of decreased oxidative stress, through an increase in the antioxidant property of unconjugated bilirubin.
Journal ArticleDOI
Inflammation and atherosclerosis in rheumatoid arthritis
TL;DR: In the context of RA the involvement of local and systemic inflammatory processes in the development and rupture of atherosclerotic plaques are described and the role of individual risk factors for coronary heart disease is discussed.
Journal ArticleDOI
Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis
Louis J. Ignarro,Claudio Napoli +1 more
TL;DR: Experimental models will help to understand how to implement NO-based therapies against atherosclerosis, and the target or goal for new drugs should be the complete restoration of NOmediated signaling pathways in atherosclerotic arteries.
References
More filters
Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
Journal ArticleDOI
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
Journal ArticleDOI
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
Journal ArticleDOI
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
Journal ArticleDOI
Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.