Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
Citations
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Physical Activity and High-Sensitivity C-Reactive Protein
TL;DR: Evidence from both cross-sectional and longitudinal investigations that physical activity lowers CRP levels in a dose-response manner is presented and factors such as body composition, sex, blood sample timing, diet and smoking, which may influence the CRP response to physical activity are examined.
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Active but transient improvement of endothelial function in rheumatoid arthritis patients undergoing long-term treatment with anti-tumor necrosis factor alpha antibody.
Carlos González-Juanatey,Ana Testa,Alberto Garcia-Castelo,Carlos Garcia-Porrua,Javier Llorca,Miguel A. González-Gay +5 more
TL;DR: This study confirms an active but transient effect of infliximab on endothelial function in RA patients treated periodically with this drug, and may support long-term use of drugs that block TNF alpha function to reduce the high incidence of cardiovascular complications in RA.
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Beneficial effects of polyphenols on cardiovascular disease
TL;DR: This review brings together some recent studies which establish the beneficial properties of polyphenols for cardiovascular disease and analyzes the mechanisms involved in these properties.
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Determinants of systemic vascular function in patients with stable chronic obstructive pulmonary disease.
Philipp Eickhoff,Arschang Valipour,Dora Kiss,Martin Schreder,Leyla Cekici,Kora Geyer,Robab Kohansal,Otto C. Burghuber +7 more
TL;DR: In patients with COPD, stepwise multiple regression analysis showed that age, sex, baseline brachial artery diameter, C-reactive protein level, leukocyte count, blood glucose level, and percentage of predicted forced expiratory volume in 1 s were independent predictors of flow-mediated dilation.
Journal Article
Telomere length of circulating leukocytes is decreased in patients with chronic heart failure
van der Pim Harst,G. Van Der Steege,de Rudolf Boer,Adriaan A. Voors,Alistair S. Hall,Marcel Mulder,van Wiekert Gilst,van Dirk Veldhuisen,null null +8 more
TL;DR: In this article, the authors found that patients with chronic heart failure (CHF) have shorter telomeres compared with age-balanced and gender-balanced healthy individuals, and the median telomere length ratio was 0.64.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.