Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
Reads0
Chats0
TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
Citations
More filters
Journal ArticleDOI
Atherosclerosis: from lesion formation to plaque activation and endothelial dysfunction.
TL;DR: The purpose of this work is to review the major theories of atherogenesis, examine the aspects of atherosclerosis that lead to disease activation and discuss aspects of disease activation that are amenable to treatment.
Journal ArticleDOI
Increased levels of asymmetric dimethylarginine in populations at risk for atherosclerotic disease. Effects of pravastatin.
TL;DR: Looking at plasma levels of asymmetric dimethylarginine, an important endogenous inhibitor of nitric oxide synthase, in populations at high risk for atherosclerosis as compared to healthy controls and individuals with hypercholesterolemia, found significantly elevated ADMA levels and reduced L-arg inine/ADMA ratios were found in individuals with diabetes type-1 as well as in hypercholesterololemia.
Journal ArticleDOI
Thematic review series: the immune system and atherogenesis. Immune function in atherogenesis.
TL;DR: This overview to a new thematic series on the immune system and Atherogenesis provides a very brief summary of current conceptions of atherogenesis, of the innate and adaptive immune systems, and of the participation of the latter in atherogensesis, with particular emphasis on studies of the involvement of the immune System in atherosclerosis reported in the last 2 years.
Journal Article
Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Commentary
Parth Patwari,Richard T. Lee,Haifeng Zhang,Yan Luo,Wei Zhang,Yun He,Shengchuan Dai,Rong Zhang,Yan Huang,Pascal Bernatchez,Frank J. Giordano,Gerald S. Shadel,William C. Sessa,Wang Min +13 more
TL;DR: It is shown that Trx2 improves EC function and reduces atherosclerotic lesions in the apolipoprotein E-deficient mouse model and increases the capacities of ECs in scavenging reactive oxygen species generated from mitochondria, resulting in increases in NO bioavailability in ECs.
Journal ArticleDOI
Endothelial dysfunction in patients with chronic periodontitis and its improvement after initial periodontal therapy.
Fehmi Mercanoglu,Huseyin Oflaz,Ogün Öz,Aslan Gökbuget,Hakan Genchellac,Murat Sezer,Yilmaz Nisanci,Sabahattin Umman +7 more
TL;DR: Endothelium functions were impaired in patients with chronic periodontitis and that they improve following initial periodontal therapy and there was no significant difference between the groups with regard to cardiovascular risk factors.
References
More filters
Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
Journal ArticleDOI
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
Journal ArticleDOI
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
Journal ArticleDOI
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
Journal ArticleDOI
Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.